Results 71 to 80 of about 492,973 (270)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Laser-driven luminescent ceramic-converted near-infrared II light source for advanced imaging and detection techniques

Light: Science & Applications
Laser-driven near-infrared II (NIR-II) light sources comprising luminescent ceramics represent a promising research frontier, yet their development remains constrained by the external quantum efficiency (EQE) and thermal stability bottleneck of current ...
Simin Gu, Huiwang Lian, Rongyi Kuang, Bibo Lou, Chonggeng Ma, Gaochao Liu, Jing Wang   +6 more
doaj   +1 more source

Argilas como catalisadores verdes na esterificação do colesterol: caracterização espectroscópica e identificação de polimorfos por métodos de análise térmica. Uma proposta laboratorial interdisciplinar para o 1º ciclo universitário Clays as green catalysts in the cholesterol esterification: spectroscopic characterization and polymorphs identification by thermal analysis methods. An interdisciplinary laboratorial proposal for the undergraduate level

Química Nova, 2009
A laboratory experiment that enables the professor to introduce the problematic of sustainable development in pharmaceutical chemistry to undergraduate students is proposed, using a simple synthetic procedure.
Teresa M. R. Maria, Rui M. D. Nunes, Mariette M. Pereira, M. Ermelinda S. Eusébio   +3 more
doaj   +1 more source

Metal-Organic Frameworks in Germany: from Synthesis to Function

, 2019
Metal-organic frameworks (MOFs) are constructed from a combination of inorganic and organic units to produce materials which display high porosity, among other unique and exciting properties.
Bon, Volodymyr, Dissegna, Stefano, Evans, Jack D., Fischer, Roland A., Garai, Bikash, Janiak, Christoph, Kaskel, Stefan, Li, Weijin, Reinsch, Helge, Senkovska, Irena, Stock, Norbert, Volkmer, Dirk   +11 more
core   +1 more source

Toward a simulation approach for alkene ring-closing metathesis : scope and limitations of a model for RCM [PDF]

, 2011
A published model for revealing solvent effects on the ring-closing metathesis (RCM) reaction of di-Et diallylmalonate 7 has been evaluated over a wider range of conditions, to assess its suitability for new applications.
Adjiman C. S., Ashworth I. W., Ashworth I. W., Bieniek M., Butcher J. C., David J. Nelson, Davide Carboni, Dias E. L., Ercolani G., Farina V., Hillier I. H., Hong S. H., Hong S. H., Hoveyda A. H., Ian W. Ashworth, Jonathan M. Percy, Kingsbury J. S., Kirby A. J., Love J. A., Mitchell L., Ritter T., Romero P. E., Sanford M. S., Scholl M., Shu C., Stewart I. C., Torker S., Tsipis A. C., van der Eide E. F., Vorfalt T., Vorfalt T., Wieberg K. B., Yee N. K., Zahnley T.   +33 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A review on sustainable synthesis methods, characterization and applications of inorganic metal complexes: Recent advances and future approaches

Results in Chemistry
Metal complexes not only play an essential role in various technologies and industries, but they are also serving with efficiencies in the fields of catalysis, medicine, dye, agrochemicals, polymers, and other important materials for human society.
Shailendra Yadav, Sankatha Prasad Sonkar, Kanha Singh Tiwari, Mrityunjay Shukla   +3 more
doaj   +1 more source

Using small molecules to facilitate exchange of bicarbonate and chloride anions across liposomal membranes [PDF]

, 2009
Bicarbonate is involved in a wide range of biological processes, which include respiration, regulation of intracellular pH and fertilization. In this study we use a combination of NMR spectroscopy and ion-selective electrode techniques to show that the ...
A Fürstner, AP Davis, AV Koulov, C Yamamoto, D Stefayne, E Gout, ED Steinle, F Hofmeister, FA Norris, FG Riddell, HG Hempling, HM Florman, J Fujinaga, Jeffery T. Davis, JL Sessler, Jose Carlos Iglesias-Sánchez, JR Casey, JW Bennett, JY Choi, K Chang, K Kavallieratos, K Tanigaki, L You, M Nguyen, MS Melvin, NM Koropatkin, NN Gerber, NR Williamson, OA Okunola, Oluyomi A. Okunola, Philip A. Gale, Pilar Prados, PV Santacroce, RA Gottlieb, Roberto Quesada, S Ohkuma, T Sato, Tomás Torroba, V Rizzo, WN Lipscomb, WW Cleland, X Li   +41 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source