Results 51 to 60 of about 492,973 (270)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Microwave assisted pyrazole derivative synthesis [PDF]
, 2007 In the past few decades, many significant advances in organic chemistry, such as the novel synthetic reagents and methods, as well as the advent of an array of analytical apparatus and techniques, have made the organic synthesis more dynamic and ...
Dash, Binay Kumar
core
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Chiroptical studies on brevianamide B : vibrational and electronic circular dichroism confronted [PDF]
, 2015 Chiroptical spectroscopy, such as electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) are highly sensitive techniques to probe molecular conformation, configuration, solvation and aggregation.
Bultinck, Patrick +7 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
CHIMIA, 1997 A short survey is given over the main fields of interest of the recently established research group for organic analytical chemistry at the University of Basel.
Michael Oehme +6 more
doaj +2 more sources
Advancements in Soft-Tissue Prosthetics Part B: The Chemistry of Imitating Life
Frontiers in Bioengineering and Biotechnology, 2020 Each year, congenital defects, trauma or cancer often results in considerable physical disfigurement for many people worldwide. This adversely impacts their psychological, social and economic outlook, leading to poor life experiences and negative health ...
Rena L. J. Cruz +3 more
doaj +1 more source
Development and study of synthetic polypeptides for biomaterial applications [PDF]
, 2013 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2013.Vita. Cataloged from PDF version of thesis.Includes bibliographical references (p.
Morey, Shannon Marie
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Microbial BiotechnologyIn this review article, a perspective on the immobilization of various hydrolytic enzymes onto magnetic nanoparticles for synthetic organic chemistry applications is presented.
F. Papatola +3 more
doaj +1 more source