Results 11 to 20 of about 6,653 (267)

Tumor microenvironment responsive Mn3O4 nanoplatform for in vivo real-time monitoring of drug resistance and photothermal/chemodynamic synergistic therapy of gastric cancer [PDF]

Journal of Nanobiotechnology, 2022
Background Postoperative chemotherapy for gastric cancer often causes multidrug resistance (MDR), which has serious consequences for therapeutic effects.
Hanrui Li, Xiaoxia Cai, Tong Yi, Yun Zeng, Jingwen Ma, Lei Li, Liaojun Pang, Na Li, Hao Hu, Yonghua Zhan   +9 more
doaj   +2 more sources

Injectable agarose hydrogels and doxorubicin-encapsulated iron-gallic acid nanoparticles for chemodynamic-photothermal synergistic therapy against osteosarcoma [PDF]

Frontiers in Chemistry, 2022
Osteosarcoma is a malignant bone cancer that usually occurs in children and adolescents. Although chemotherapy, radiotherapy and other methods have been used to treat osteosarcoma, these therapeutic regimens fail to cure this disease completely.
Hongliang Ying, Haitian Wang, Guangchuan Jiang, Han Tang, Lingrui Li, Jinrui Zhang   +5 more
doaj   +2 more sources

Tumor cell membrane-camouflaged responsive nanoparticles enable MRI-guided immuno-chemodynamic therapy of orthotopic osteosarcoma

Bioactive Materials, 2022
Osteosarcoma is a refractory bone disease in young people that needs the updating and development of effective treatment. Although nanotechnology is widely applied in cancer therapy, poor targeting and inadequate efficiency hinder its development.
Liwen Fu, Weiying Zhang, Xiaojun Zhou, Jingzhong Fu, Chuanglong He   +4 more
doaj   +2 more sources

Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation.
Mingzhu Chen, Ziqi Wang, Weilong Suo, Zhirong Bao, Hong Quan   +4 more
openaire   +4 more sources

Multifunctional drug delivery nanoparticles for combined chemotherapy/chemodynamic/photothermal therapy against colorectal cancer through synergistic cuproptosis/ferroptosis/apoptosis

Materials Today Bio
The use of combination therapies that employ a variety of cell death mechanisms has emerged as a promising avenue of research in the treatment of cancer.
Xiuzhang Yan, Heshi Liu, Lei Guo, Chang Liu, Shichen Zhang, Xue Wang, Yixin Tang, Rui Zhou, Xin Jiang, Erlei Wang, Shuohui Gao, Caina Xu   +11 more
doaj   +2 more sources

Fe3O4@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy [PDF]

Journal of Nanobiotechnology, 2021
AbstractElectrodynamic therapy (EDT) has recently emerged as a potential external field responsive approach for tumor treatment. While it presents a number of clear superiorities, EDT inherits the intrinsic challenges of current reactive oxygen species (ROS) based therapeutic treatments owing to the complex tumor microenvironment, including glutathione
Tong Chen, Qiang Chu, Mengyang Li, Gaorong Han, Xiang Li   +4 more
openaire   +4 more sources

Biomolecule-tailored chiral nickel oxide nanozymes amplify autophagy-mediated tumor ablation via synergistic photodynamic-chemodynamic therapy [PDF]

Materials Today Bio
Chiral nanomaterial-mediated phototherapy has attracted attention as an emerging tumor treatment method. In this study, we synthesized chiral nickel oxide (L/D-Cys-NiO) photosensitizers via surface modulation using chiral cysteine molecules, thereby ...
Wei Pang, Yining Shao, Hefeng Xu, Tianqi Li, Linxuan Wu, Zhipeng Liu, Lei Zhang, Wei Chen, Yiwen Li, Dake Xu, Jiaji Cheng, Xiaoqian Xu   +11 more
doaj   +2 more sources

A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma [PDF]

Fundamental Research
: Hepatocellular carcinoma (HCC) is the most common primary liver cancer with a poor prognosis. Chemotherapy is one of the first-line clinical therapeutic strategies for HCC.
Chen Guo, Rui Dou, Linbang Wang, Jiayu Zhang, Xiaomeng Cai, Jiaruo Tang, Zhengyuan Huang, Xiaoguang Liu, Jun Chen, Hanqing Chen   +9 more
doaj   +2 more sources

DNA nanomachine‐driven chemodynamic therapy against glioblastoma

Aggregate
Chemodynamic therapy (CDT) has shown promising antitumor effects in various malignant tumors. However, its application for glioblastoma (GBM) is significantly hindered by the challenge of delivering CDT agents across the blood‐brain barrier (BBB) and ...
Xiaodie Li, Yufei Lan, Xin Fu, Xin Luo, Jie Chen, Wenxin Zhang, Boming Zuo, Tao Yang, Boyang Liu, Chao Zhang, Hongbo Guo   +10 more
doaj   +2 more sources

A Glutathione-Consuming Bimetallic Nano-Bomb with the Combination of Photothermal and Chemodynamic Therapy for Tumors: An in vivo and in vitro Study [PDF]

Int J Nanomedicine
Jing Kong,1,* Jiabin Lai,2– 4,* Min Wang,5,* Yi Xie,1 Haifei He,6 Jiayu Gu,7 Tao Pan,6 Zhiqiang Lu,8 Lifeng Jiang3,4 1Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou,
Gu J, He H, Jiang L, Kong J, Lai J, Lu Z, Pan T, Wang M, Xie Y   +8 more
core   +3 more sources