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Harnessing Inorganic Nanomaterials for Chemodynamic Cancer Therapy
Nanomedicine, 2022The most important aspect of chemodynamic therapy (CDT) is the harnessing of Fenton or Fenton-like chemistry for cancer therapy within the tumor microenvironment, which occurs because of the moderate acidity and overexpressed H2O2 in the tumor microenvironment.
Dhelal F, Mohammed +6 more
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Camouflaged Nanoreactors Mediated Radiotherapy-Adjuvant Chemodynamic Synergistic Therapy
ACS Nano, 2023Chemodynamic therapy based on the Fenton-like catalysis ability of Fe3O4 has the advantages of no involvement of chemical drugs and minimal adverse effects as well as the limitation of depletable efficacy. Radiotherapy based on high-energy radiation offers the convenience of treatment and cost-effectiveness but lacks precision and cellular adaptation ...
Mingze Lu +12 more
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Glutathione-triggered nanoplatform for chemodynamic/metal-ion therapy
Journal of Materials Chemistry B, 2021The integration of metal-ion therapy and hydroxyl radical (˙OH)-mediated chemodynamic therapy (CDT) holds great potential for anticancer treatment with high specificity and efficiency.
Min Liu +4 more
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Magnetic-Optical Imaging for Monitoring Chemodynamic Therapy
Chemical Research in Chinese Universities, 2021Chemodynamic therapy kills cancer cells with reactive oxygen species generated by endogenous triggers in the tumor microenvironment. Although chemodynamic therapy is blossoming in recent years, their therapy process still faces a series of hampers. The unknown catalytic activity of chemodynamic therapy reagents may lead to unpredictable therapy effects,
Youjuan Wang +3 more
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Metal–organic complex-based chemodynamic therapy agents for cancer therapy
Chemical Communications, 2020This feature article summarizes the recent progress in the study of chemodynamic therapy agents based on metal–organic complexes.
Eunbin Hwang, Hyo Sung Jung
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Recent advances in enhanced chemodynamic therapy strategies
Nano Today, 2021Abstract Chemodynamic therapy (CDT) is a novel therapeutic modality that employs Fenton or Fenton-like reactions to destroy cancer cells via the disproportionation of intratumoral hydrogen peroxide (H2O2) to the highly toxic hydroxyl radical (•OH) without external energy input.
Qiwei Tian +7 more
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Stimuli‐activatable nanomedicines for chemodynamic therapy of cancer
WIREs Nanomedicine and Nanobiotechnology, 2020AbstractChemodynamic therapy (CDT) takes the advantages of Fenton‐type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide ...
Weiqi Wang +6 more
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Biocompatible tumor-targeted GQDs nanocatalyst for chemodynamic tumor therapy
Journal of Materials Chemistry B, 2022To deal with tumor microenvironment, chemodynamic therapy has been developed, which uses nanocatalysts simulating peroxidase to convert high concentration hydrogen peroxide into toxic hydroxyl radicals in situ and effectively kills tumor cells.
Zixia Wu +9 more
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RuCu Nanosheets with Ultrahigh Nanozyme Activity for Chemodynamic Therapy
Advanced Healthcare Materials, 2023AbstractNanoenzymes have been widely explored for chemodynamic therapy (CDT) in cancer treatment. However, poor catalytic efficiency of nanoenzymes, especially in the tumor microenvironment with insufficient H2O2 and mild acidity, limits the effect of CDT.
Jian Yang +7 more
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Recent Advances on NIR‐II Light‐Enhanced Chemodynamic Therapy
Advanced Healthcare Materials, 2023AbstractChemodynamic therapy (CDT) is a particular oncological therapeutic strategy by generates the highly toxic hydroxyl radical (•OH) from the dismutation of endogenous hydrogen peroxide (H2O2) via Fenton or Fenton‐like reactions. However, single CDT therapies have been limited by unsatisfactory efficacy.
Gui‐long Wu +2 more
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