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Recent progress of chemodynamic therapy-induced combination cancer therapy
Nano Today, 2020Abstract Chemodynamic therapy (CDT) is an emerging cancer treatment strategy that uses CDT agents to convert hydrogen peroxide (H2O2) into the hydroxyl radical ( OH), the most harmful reactive oxygen species (ROS) by the Fenton/Fenton-like reactions, thus inducing cell apoptosis and necrosis.
Xianwen Wang +3 more
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A Forward Vision for Chemodynamic Therapy: Issues and Opportunities
Angewandte Chemie International Edition, 2023AbstractSince the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in the field of chemodynamic therapy (CDT). However, the exact mechanism of CDT is obscured by the unique tumor chemical environment and inevitable nanoparticle‐cell interactions, thus impeding further development.
Peiran Zhao, Huiyan Li, Wenbo Bu
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Inorganic nanoparticle agents for enhanced chemodynamic therapy of tumours
Nanoscale, 2023Recent strategies and underlying mechanisms that have been used to improve the CDT performance using inorganic nanoparticles are summarized.
Sagang Koo +4 more
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Mesoporous peroxidase nanozyme for synergistic chemodynamic therapy and chemotherapy
Colloids and Surfaces B: Biointerfaces, 2022Peroxidase nanozyme, enabling decomposition of hydrogen peroxide (H2O2) into highly toxic hydroxyl radical (•OH), is an emerging technology for tumor treatment. However, limited by the low H2O2 level in the tumor microenvironment, the standalone peroxidase nanozyme-mediated therapy usually fails to achieve desirable therapeutic outcomes.
Xingyu, Fan +8 more
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Mn–DNA coordination of nanoparticles for efficient chemodynamic therapy
Chemical Communications, 2021Manganese ions were efficiently delivered by long single strand DNA ligands and caused the apoptosis of cancer cells by the Fenton-like reaction.
Li Lin +8 more
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Porphyrin–ferrocene conjugates for photodynamic and chemodynamic therapy
Organic & Biomolecular Chemistry, 2018Porphyrin–ferrocene conjugates were designed and synthesized for photodynamic and chemodynamic therapy.
Zhitao Lei +4 more
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A procedurally activatable nanoplatform for chemo/chemodynamic synergistic therapy
Biomaterials Science, 2022The present work showed a H2O2/GSH procedurally activatable nanoplatform (Cu9S5-PEG/DOX NSs) as a vector of drugs released by responsive morphologic transformation and the co-activated Fenton agent for tumor-specific synergistic therapy.
Wen Han +5 more
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Copper-based theranostic nanocatalysts for synergetic photothermal-chemodynamic therapy
Acta Biomaterialia, 2022Chemodynamic therapy (CDT) has aroused extensive attention as a potent therapeutic modality. However, its practical application is severely restricted by the strong acidity requirement for Fenton reaction and upregulated antioxidant defense within metastatic breast cancer.
Wenbao Zuo +9 more
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Nanoplatform-based synergistic cancer Immuno-Chemodynamic therapy
International Journal of PharmaceuticsImmunotherapy has made excellent breakthroughs in the field of cancer treatments, but faces challenges with low immunogenicity of tumor cells and an immunosuppressive tumor microenvironment (ITME). The emerging chemodynamic therapy (CDT) based on the Fenton/Fenton-like reaction can induce immunogenic cell death (ICD) to enhance tumor immunogenicity ...
Shuaizhi, Kong +4 more
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A biomimetic nanoenzyme for starvation therapy enhanced photothermal and chemodynamic tumor therapy
Nanoscale, 2020Glucose oxidase decorated N-doped carbon nanoparticles have been designed as a biomimetic nanoenzyme, which present prominent synergistic effects of starvation therapy enhancing photothermal therapy and chemodynamic therapy against tumors.
Keqiang Xu +10 more
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