Results 101 to 110 of about 189,065 (308)

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Gut dysbiosis promotes islet-autoimmunity by increasing T-cell attraction in islets via CXCL10 chemokine [PDF]

CXCL10 is an IFNγ-inducible chemokine implicated in the pathogenesis of type 1 diabetes. T-cells attracted to pancreatic islets produce IFNγ, but it is unclear what attracts the first IFNγ -producing T-cells in islets.
Liu Xin, Christen Urs, Silojärvi Satu, Luster Andrew D, Kay Thomas WH, Pöysti Sakari, Catterall Tara, Thomas Helen E, Hänninen Arno, Brodnicki Thomas C, Mackin Leanne   +10 more
core   +1 more source

Furin is a chemokine-modifying enzyme: in vitro and in vivo processing of CXCL10 generates a C-terminally truncated chemokine retaining full activity [PDF]

, 2004
Chemokines comprise a class of structurally related proteins that are involved in many aspects of leukocyte migration under basal and inflammatory conditions.
André M. Deelder, Dijkman, R., Elizabeth M.H. van der Raaij-Helmer, Deelder, André M, van der Plas, M.., Tensen, C.P., Balog, Crina I A, van der Raaij-Helmer, Elizabeth M H, van der Plas, Mariena J A, van der Schors, R, van der Raaij-Helmer, E.M.H., Paul J. Hensbergen, Roel C. van der Schors, Schors, R van der, Tensen, Cornelis P, Leurs, R., Dijkman, Remco, Cornelis P. Tensen, Deelder, A.M., Smit, M.J.; id_orcid, Leurs, Rob, Smit, M.J., Verzijl, Dennis, Rob Leurs, Balog, C.I., Plas, M.. van der, Crina I.A. Balog, Mariena J.A. van der Plas, Dennis Verzijl, Remco Dijkman, Hensbergen, Paul J, Raaij-Helmer, E.M.H. van der, Martine J. Smit, Smit, Martine J, Hensbergen, P, Verzijl, D., van der Schors, Roel C   +36 more
core   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells

Arthritis Research & Therapy, 2017
Background The peripheral blood (PB) monocyte pool contains osteoclast progenitors (OCPs), which contribute to osteoresorption in inflammatory arthritides and are influenced by the cytokine and chemokine milieu.
Alan Sucur, Zrinka Jajic, Marinko Artukovic, Marina Ikic Matijasevic, Branimir Anic, Darja Flegar, Antonio Markotic, Tomislav Kelava, Sanja Ivcevic, Natasa Kovacic, Vedran Katavic, Danka Grcevic   +11 more
doaj   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Data_Sheet_1_Pathogen Evasion of Chemokine Response Through Suppression of CXCL10.docx

, 2019
Clearance of intracellular pathogens, such as Leishmania (L.) major, depends on an immune response with well-regulated cytokine signaling. Here we describe a pathogen-mediated mechanism of evading CXCL10, a chemokine with diverse antimicrobial functions,
Benjamin H. Schott (7147751), Jeffrey S. Smith (77927), Esme D. Trahair, J. Will Thompson, Sudarshan Rajagopal (2947521), Alejandro L. Antonia (7147739), Richard Lee Reinhardt (7147754), Richard Lee Reinhardt, Dennis C. Ko, Benjamin H. Schott, Dennis C. Ko (7147757), Kelly J. Pittman, Kyle D. Gibbs, J. Will Thompson (202608), Sudarshan Rajagopal, Esme D. Trahair (7147745), Jeffrey S. Smith, Amelia T. Martin (7147748), Alejandro L. Antonia, Kyle D. Gibbs (7147742), Kelly J. Pittman (3216036), Amelia T. Martin   +21 more
core   +1 more source

Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases

, 2020
Chemokine C–X–C ligand 10 (CXCL10), also known as interferon-γ-inducible protein 10 (IP-10), exerts biological function mainly through binding to its specific receptor, CXCR3.
Siyang Wang, Lingling Wu, Jie Gao, Xiangmei Chen   +3 more
core   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source