Results 271 to 280 of about 189,065 (308)

Chemokine production and chemokine receptor expression by human glioma cells: Role of CXCL10 in tumour cell proliferation

Journal of Neuroimmunology, 2008
The expression of chemokine receptors and chemokine production by adult human non-transformed astrocytes, grade III astrocytoma and grade IV glioblastoma tumour cell lines were determined. Here, we show an increased expression of CXCR3 and CXCR4, and a decreased expression of CXCR1 and CCR4 by glioma cells compared to adult human astrocytes.
D K Male, Ignacio A Romero
exaly   +4 more sources

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Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing

Cytokine, 2006
No study has evaluated contemporaneously serum CXC and CC chemokines changes in normal ageing. Serum levels of CXCL10 (sCXCL10) (CXC) and CCL2 (sCCL2) (CC) prototype chemokines have been measured in 164 healthy subjects, from 10 to 79 years of age (82 males/82 females).
Alessandro Antonelli, Mario Rotondi, Poupak Fallahi   +2 more
exaly   +4 more sources

Phosphodiesterase Type 5 Inhibitor Sildenafil Decreases the Proinflammatory Chemokine CXCL10 in Human Cardiomyocytes and in Subjects with Diabetic Cardiomyopathy [PDF]

Inflammation, 2016
T helper 1 (Th1) type cytokines and chemokines are bioactive mediators in inflammation underling several diseases and co-morbid conditions, such as cardiovascular and metabolic disorders.
Luigi Di Luigi, Clarissa Corinaldesi, Marta Colletti   +2 more
exaly   +3 more sources

Pro-inflammatory effects of the Th1 chemokine CXCL10 in acquired aplastic anaemia

Cytokine, 2017
CXCL10/IFN-γ-induced protein 10 (IP-10) and its corresponding receptor CXCR3 have long been considered to be involved in the pathophysiology of type 1 T (Th1) cell-orientated autoimmune diseases. However, the exact role of CXCL10 in the pathogenesis of aplastic anaemia (AA) has not been thoroughly studied.
Junhong, Li, Meili, Ge, Shihong, Lu, Jun, Shi, Xingxin, Li, Min, Wang, Jinbo, Huang, Yingqi, Shao, Zhendong, Huang, Jing, Zhang, Neng, Nie, Yizhou, Zheng   +11 more
openaire   +3 more sources

Chemokine CXCL10 regulates pain behaviors via PI3K-AKT signaling pathway in mice

Neuropeptides, 2022
The analgesic efficacy of morphine can be affected by a variety of factors. Our previous studies demonstrated that chemokine (CXC motif) ligand 10 (CXCL10) could induce algesia directly and attenuate the analgesic effect produced by a single dose of ...
Xiaoling Peng, Huilian Bu, Xiaoqian Jia   +2 more
exaly   +2 more sources

Th1 (CXCL10) and Th2 (CCL2) chemokine expression in patients with immune thrombocytopenia

Human Immunology, 2010
Immune thrombocytopenia (ITP) is an acquired organ-specific autoimmune disease with a polarization of T(h)1. Both the T(h)1 chemokine CXCL10 and T(h)2 chemokine CCL2 have been studied in several autoimmune diseases, but the status of these chemokines in ITP is still unknown. The aims of this study were to determine the expression of CXCL10 and CCL2 and
Dongsheng Gu, Zhenping Chen, Weiting Du   +2 more
exaly   +3 more sources

Maternal serum concentrations of the chemokine CXCL10/IP-10 are elevated in acute pyelonephritis during pregnancy

Journal of Maternal-Fetal and Neonatal Medicine, 2007
OBJECTIVE: Acute pyelonephritis is one of the most frequent medical complications of pregnancy, as well as a common cause of antepartum hospitalization. Interferon (IFN)-gamma inducible protein, CXCL10/IP-10, is a member of the CXC chemokine family with ...
Roberto Romero, Jimmy Espinoza, Juan Pedro Kusanovic   +2 more
exaly   +2 more sources

Chemokine CXCL10/CXCR3 signaling contributes to neuropathic pain in spinal cord and dorsal root ganglia after chronic constriction injury in rats.

Neuroscience Letters, 2019
Inflammatory cytokines and chemokines play essential roles in the occurrence and persistence of neuropathic pain (NP). Chronic constriction injury (CCI) enhances the activation of p-ERK, which is involved in neuropathic pain.
Yonglin Chen, Dekun Yin, B. Fan, Xiang Zhu, Qiuping Chen, Yao Li, Shunxing Zhu, Rongxiang Lu, Zhongling Xu   +8 more
semanticscholar   +1 more source

Inhibition of Pulmonary Fibrosis by the Chemokine IP-10/CXCL10

American Journal of Respiratory Cell and Molecular Biology, 2004
Abstract Pulmonary fibrosis is an enigmatic and devastating disease with few treatment options, now thought to result from abnormal wound healing in the lung in response to injury. We have previously noted a role for the chemokine interferon γ–inducible protein of 10 kD (IP-10)/CXC chemokine ligand 10 in the regulation of cutaneous ...
Andrew M, Tager, Richard L, Kradin, Peter, LaCamera, Scott D, Bercury, Gabriele S V, Campanella, Carol P, Leary, Vasiliy, Polosukhin, Long-Hai, Zhao, Hideo, Sakamoto, Timothy S, Blackwell, Andrew D, Luster   +10 more
openaire   +2 more sources

Generation and Characterization of a Functional Nanobody Against Inflammatory Chemokine CXCL10, as a Novel Strategy for the Treatment of Multiple Sclerosis.

CNS and Neurological Disorders - Drug Targets, 2019
BACKGROUND & OBJECTIVE Chemokines and their receptors play a pivotal role in the pathogenesis of various autoimmune diseases such as multiple sclerosis, infectious diseases, and also in cancer metastasis via attraction of the pathogenic immune cells into
Tahereh Sadeghian-Rizi, M. Behdani, H. Khanahmad, H. Sadeghi, A. Jahanian-Najafabadi   +4 more
semanticscholar   +1 more source