Results 221 to 230 of about 375,096 (307)

STAT3 regulates NK and NKT cell differentiation through C-X3-C motif chemokine receptor 1  (CX3CR1) in hyper-IgE syndrome. [PDF]

Mol Biomed
Liu J, Yang J, Tang J, Tang H, Dai X, Jin P, Huang Y, Li Z, Zhang Z, Guo X, Bitzan M, Yin X, Liu C.   +12 more
europepmc   +1 more source

Bioprinted Tumor Microenvironment Models Reveal Immune Evasion and Guide CAR‐NK Therapeutic Strategies

Advanced Science, EarlyView.
This study presents a 3D embedded bioprinting platform that recapitulates key stromal features of the tumor microenvironment using fibroblasts and lung‐derived ECM. The model enables functional assessment of CAR‐NK cells and provides a versatile tool to support the development of next‐generation immunotherapeutic strategies against solid tumors ...
Dahong Kim, Seona Jo, In‐Hwan Jang, Yu‐Jin Kim, Youngmee Jung, Junhyoung Ahn, Hyungjun Lim, Jae Jong Lee, Kangwon Lee, Tae‐Don Kim, Su A Park   +10 more
wiley   +1 more source

Signal termination of the chemokine receptor CCR9 is governed by an arrestin-independent phosphorylation mechanism. [PDF]

J Biol Chem
Lamme TD, Smit MJ, Schafer CT.
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Atypical activation and molecular glue-like dimerization mechanism of an intrinsically-biased chemokine receptor

Banerjee N, Ganguly M, Reyaz A, Mishra S, Dalal A, Guo X, Qiu X, Meyrath M, Palmer CB, Guo H, Song S, Sinha S, Roy N, Mukherjee D, Tiwari D, Yadav MK, Chevigne A, Robinson CV, Chen X, Banerjee R, Shukla AK.   +20 more
europepmc   +1 more source

C-X-C chemokine receptor CXCR4 mediates diurnal changes in the aggregation and dispersion of CD8⁺ T cells within the tumor microenvironment. [PDF]

Int J Cancer
Tsuruta A, Fujimoto M, Hiraoka Y, Taniguchi A, Shiiba Y, Inoki T, Yamauchi T, Yoshida Y, Matsunaga N, Ohdo S, Koyanagi S.   +10 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms. [PDF]

JACC Basic Transl Sci
Elizondo-Benedetto S, Sastriques-Dunlop S, Detering L, Arif B, Heo GS, Sultan D, Luehmann H, Zhang X, Gao X, Bredemeyer A, Zaghloul MS, Harrison K, Thies D, McDonald L, Combadière C, Lin CY, Kang Y, Zheng J, Ippolito J, Laforest R, Lavine K, Gropler RJ, English SJ, Zayed MA, Liu Y.   +24 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Differential expression pattern of CC chemokine receptor 7 guides precision treatment of hepatocellular carcinoma. [PDF]

Signal Transduct Target Ther
Qin J, Gong Q, Zhou C, Xu J, Cheng Y, Xu W, Zhu D, Liu Y, Zhang Y, Wang Y, Gao L, Li L, Hou W, Li Q, Liu B, Zhu Y, Wang Z, Shi J, Qiu S, Liang C.   +19 more
europepmc   +1 more source