Results 251 to 260 of about 240,302 (314)

ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function. [PDF]

Eur J Clin Invest
Dicenta-Baunach V, Laspa Z, Schaale D, Sigle M, Bayrak A, Castor T, Pillaiyar T, Laufer S, Gawaz MP, Rohlfing AK.   +9 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

CCL2/C-C chemokine receptor type 2-mediated interactions among mast cells, basophils, and endothelial cells. [PDF]

Clin Transl Allergy
Rihar M, Bahri R, Forstnerič V, Bulfone-Paus S, Korošec P.   +4 more
europepmc   +1 more source

Chemokine receptor distribution on the surface of repolarizing T cells. [PDF]

Biophys J
Mazalo JK, Tay SS, Kempe D, Biro M.
europepmc   +1 more source

Conformational dynamics underlying atypical chemokine receptor 3 activation. [PDF]

Proc Natl Acad Sci U S A
Otun O, Aljamous C, Del Nero E, Arimont-Segura M, Bosma R, Zarzycka B, Girbau T, Leyrat C, de Graaf C, Leurs R, Durroux T, Granier S, Cong X, Bechara C.   +13 more
europepmc   +1 more source

Interaction and dynamics of chemokine receptor CXCR4 binding with CXCL12 and hBD-3. [PDF]

Commun Chem
Penfield J, Zhang L.
europepmc   +1 more source

Chemokine receptor hetero-oligomers regulate monocyte chemotaxis. [PDF]

Life Sci Alliance
Enten GA, Gao X, McGee MY, Weche M, Majetschak M.   +4 more
europepmc   +1 more source

A Fluorescent Probe Enables the Discovery of Improved Antagonists Targeting the Intracellular Allosteric Site of the Chemokine Receptor CCR7. [PDF]

J Med Chem
Wurnig SL, Huber ME, Weiler C, Baltrukevich H, Merten N, Stötzel I, Steffen T, Chang Y, Klammer RHL, Baumjohann D, Kiermaier E, Kolb P, Kostenis E, Schiedel M, Hansen FK.   +14 more
europepmc   +1 more source

Plasma membrane rather than endosomal Gq signaling drives transcriptional activity by the viral chemokine receptor US28 in glioblastoma

Daly C, Wright A, Heukers R, McKee CM, Coll RC, Evergren E, Smit MJ, Thomsen AR, Plouffe B.   +8 more
europepmc   +1 more source

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Chemokines, chemokine receptors and hematopoiesis

Immunological Reviews, 2000
Hematopoiesis during steady state conditions is regulated and finely tuned by a network of cytokines and their effects on hematopoietic stem and progenitor cells and on accessory cells that influence the stem and progenitor cells. Amongst the numerous cytokines implicated in this regulation are members of the CC, CXC and C family of chemokines.
B S, Youn, C, Mantel, H E, Broxmeyer
openaire   +2 more sources