Results 281 to 290 of about 369,183 (362)

An overview of the role of chemokine CX3CL1 (Fractalkine) and CX3C chemokine receptor 1 in systemic sclerosis. [PDF]

Immun Inflamm Dis
Pezeshkian F, Shahriarirad R, Mahram H.
europepmc   +1 more source

RANTES Binding and Down-Regulation by a Novel Human Herpesvirus-6 β Chemokine Receptor

, 2000
R Milne, Claire Mattick, Linda Nicholson, Prema Devaraj, Antonio Alcamı́, Ursula A. Gompels   +5 more
openalex   +1 more source

Novel Antimicrobial Protein Fibroblast Growth Factor 8 Accelerates Skin Wound Healing via Directly Inhibiting Bacteria and Activating Glycolysis

Advanced Science, EarlyView.
Wound infections induce gcFGF8a expression, which subsequently executes direct antimicrobial activity to suppress local infection while simultaneously activating the FGFR4‐mediated ERK/AKT‐mTOR signaling cascade, thereby upregulating HIF1α and enhancing glycolysis. These coordinated actions synergistically promote tissue repair by eliminating pathogens
Ya‐Zhen Hu, Ting Wang, Chang‐Song Wu, Jie Wang, Xue‐Qing Han, Yong‐An Zhang, Xu‐Jie Zhang   +6 more
wiley   +1 more source

Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess. [PDF]

Sci Rep
Wang BH, Robert R, Marques FZ, Rajapakse N, Kiriazis H, Mackay CR, Kaye DM.   +6 more
europepmc   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Constitutive activity of an atypical chemokine receptor revealed by inverse agonistic nanobodies

Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Crudden C, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, Heukers R, Schafer CT, Smit MJ.   +17 more
europepmc   +1 more source

Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe. [PDF]

ACS Chem Biol
den Hollander LS, Beerkens BLH, Dekkers S, van Veldhoven JPD, Ortiz Zacarías NV, van der Horst C, Sieders EG, de Valk B, Wang J, IJzerman AP, van der Es D, Heitman LH.   +11 more
europepmc   +1 more source

Bacteroides Fragilis‐Derived Outer Membrane Vesicles Deliver MiR‐5119 and Alleviate Colitis by Targeting PD‐L1 to Inhibit GSDMD‐Mediated Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
Bacteroides fragilis‐derived outer membrane vesicles deliver miR‐5119 and alleviate colitis by targeting PD‐L1 to inhibit GSDMD‐mediated neutrophil extracellular trap formation. Abstract Inflammatory bowel disease (IBD) results from a breakdown in the symbiotic relationship between the intestinal commensal microflora and the mucosal immune system.
Yi Yang, Lanmengxi Yang, Yilin Yang, Haiyi Deng, Shiyu Su, Yinxiao Xia, Jin Su, Yuheng Liu, Junwei Wu, Jing Zhang, Yao Liao, Lifu Wang   +11 more
wiley   +1 more source

Chemokine receptor PET imaging: Bridging molecular insights with clinical applications. [PDF]

Nucl Med Biol
Hunter C, Larimer B.
europepmc   +1 more source

Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y. L. Lau, Zhiguo Li, Zaal Kokaia, Fu‐Dong Shi, Chao Zhang   +13 more
wiley   +1 more source