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Targeting chemokines and chemokine receptors with antibodies
Drug Discovery Today: Technologies, 2012Chemokines and their receptors are highly interesting therapeutic targets for pharmaceutical and biotechnology companies. In particular, industrial development pipelines are filled with new chemokine-targeting drugs to treat inflammatory diseases and malignancies.
Christophe Blanchetot +7 more
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Chemokines and chemokine receptors in infectious diseases [PDF]
Immunology & Cell Biology, 1999 Today, 10 years after the discovery of IL‐8, chemokines (chemotactic cytokines) are seen as the stimuli that largely control leucocyte migration. Chemokines are low molecular weight chemoattractant cytokines secreted by a variety of cells, including leucocytes, epithelial cells, endothelial cells, fibroblasts and numerous other cell types.
Surendran Mahalingam +3 more
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Chemokines and Chemokine Receptors Encoded by Cytomegaloviruses
2008CMVs carry several genes that are homologous to genes of the host organism. These include genes homologous to those encoding chemokines (CKs) and G protein-coupled receptors (GPCRs). It is generally assumed that these CMV genes were hijacked from the host genome during the long co-evolution of virus and host.
Patrick S. Beisser +3 more
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Chemokines and chemokine receptors in renal pathology
Current Opinion in Nephrology and Hypertension, 2003Chemokines are members of the largest group of chemotactic cytokines, and were the first shown to be able to engage specific subpopulations of inflammatory cells. Accordingly, our expanding knowledge in chemokine biology has enlarged our understanding of inflammatory cell interactions, lymphopoesis, specificity of cell recruitment, and a variety of ...
Charles E. Alpers, Stephan Segerer
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Chemokines and chemokine receptors in leukocyte trafficking
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002Chemokines regulate inflammation, leukocyte trafficking, and immune cell differentiation. The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is probably the best understood of these processes, and information on chemokines in inflammation, asthma, and neurological diseases is rapidly increasing. Over the past 15 years,
Klaus Ley, Timothy S. Olson
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Recent Advances in Chemokines and Chemokine Receptors
Critical Reviews™ in Immunology, 1999Chemokines are a superfamily of small cytokine-like molecules which have been described primarily on the basis of their ability to mediate the migration of verious cell types, particularly those of lymphoid origin. The receptors for these molecules are all seven-transmembrane domain G protein-coupled receptors that have historically been excellent ...
Albert Zlotnik +2 more
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Chemokines and chemokine receptors in rheumatoid arthritis
Seminars in Immunology, 2003Chemokines are chemotactic cytokines involved in a number of pathological processes, including inflammatory conditions. Chemokines play a role in the pathogenesis of various inflammatory diseases. Based on a burgeoning body of literature, RA was chosen as a prototype to discuss this issue. In this review, the authors give a detailed introduction to the
Joon Bae Kim +2 more
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Anergy and chemokine receptors
Medical Hypotheses, 2002The human immunodeficiency virus (HIV) induces a spectrum of immune abnormalities in the host by binding to CD4 molecules and chemokine receptors. Anergy, apoptosis, and immune activation are among the diverse immunological changes observed in the host.
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Chemokine sequestration by atypical chemokine receptors
Biochemical Society Transactions, 2006Leucocyte migration is essential for robust immune and inflammatory responses, and plays a critical role in many human diseases. Chemokines, a family of small secreted protein chemoattractants, are of fundamental importance in this process, directing leucocyte trafficking by signalling through heptahelical G-protein-coupled receptors expressed by the ...
Christopher A.H. Hansell +2 more
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Chemokines and Chemokine Receptors in the Brain
2009Besides their well-established role of inducing cell migration in the immune system, it is now proven that chemokines and their receptors also play a role in the central nervous system (CNS). The best known central action is the ability of chemokines to act as immunoinflammatory mediators.
Ghazal Banisadr +3 more
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