Results 241 to 250 of about 48,525 (279)

The chemokine receptor, CCR5

The International Journal of Biochemistry & Cell Biology, 2004
The chemokine receptor, CCR5, is a G protein coupled receptor responsible for some of the effects of the chemokines CCL3, CCL4 and CCL5. It is also one of the co-receptors for the entry of human immunodeficiency virus-1 (HIV-1) into cells. Regulation of CCR5 number on cells is, therefore, important for determining the infection rate by HIV-1.
Mueller, A., Strange, P. G.
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Chemokine receptor CCR5: polymorphism at protein level

Biochemical and Biophysical Research Communications, 2002
Polymorphisms in chemokine receptor CCR5 genes have been implicated in HIV disease progression, resistance, or non-progressive infection. Multiple CCR5 transcripts and mRNA diversity have also been identified. This study presents evidence to show that two distinct forms of CCR5 protein, 62 and 42k Da, are present in human lymphocytic cells and monkey ...
Shunji, Suzuki, Tomoko, Miyagi, Linda F, Chuang, Peter M, Yau, Roy H, Doi, Ronald Y, Chuang   +5 more
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Diverse signalling by different chemokines through the chemokine receptor CCR5

Biochemical Pharmacology, 2006
We have investigated the signalling properties of the chemokine receptor, CCR5, using several assays for agonism: stimulation of changes in intracellular Ca(2+) or CCR5 internalisation in CHO cells expressing CCR5 or stimulation of [(35)S]GTPgammaS binding in membranes of CHO cells expressing CCR5.
Mueller, A., Mahmoud, N. G., Strange, P. G.   +2 more
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Chemokine receptor CCR5 polymorphisms and Chagas’ disease cardiomyopathy

Tissue Antigens, 2001
Abstract: In this study we investigated the possible role of two CCR5 gene polymorphisms, CCR5Δ32 deletion and CCR5 59029 A→G promoter point mutation, in determining the susceptibility to Trypanosoma cruzi infection as well as in the development of chagasic heart disease.
J E, Calzada, A, Nieto, Y, Beraún, J, Martín   +3 more
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Polymorphisms in CCR5 chemokine receptor gene in Japan

International Journal of Immunogenetics, 2007
SummaryMutations in the human CC chemokine receptor 5 (CCR5) gene may alter the expression or function of the protein product, thereby altering chemokine binding/signalling or human immunodeficiency virus type 1 (HIV‐1) infection of the cells that normally express CCR5 protein.
H, Liu, E E, Nakayama, I, Theodorou, Y, Nagai, S, Likanonsakul, C, Wasi, P, Debre, A, Iwamoto, T, Shioda   +8 more
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Clinical studies with chemokine receptor-5 (CCR5)-inhibitors

Current Opinion in HIV and AIDS, 2012
To summarise recently published clinical studies of chemokine receptor-5 (CCR5)-blockers, including the small-molecule blocker, maraviroc (MVC) and CCR5-monoclonal antibodies for HIV. MVC may have immunomodulating properties through CCR5-blockade. MVC appears well tolerated and penetrates the central nervous system.
Christoph, Boesecke, Sarah L, Pett
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CCR5 Chemokine Receptors: Gatekeepers of HIV-1 Infection

Current Drug Target -Infectious Disorders, 2002
With the discovery that CCR5 is the critical protein required for infection by M-tropic HIV, has come huge research efforts, both in academia and industry, to try to exploit this finding. Thus, research advances in the fields of virology, structural protein chemistry, and receptor pharmacology have combined to add a new understanding to the process of ...
Wieslaw M, Kazmierski, Larry, Boone, Wendell, Lawrence, Chris, Watson, Terry, Kenakin   +4 more
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Small Molecule Antagonists of the Chemokine Receptor CCR5

Current Topics in Medicinal Chemistry, 2010
This review will focus on the discovery and clinical development of small molecule antagonists of CCR5 for the treatment of HIV-1/AIDS, as well as for the potential treatment of inflammatory diseases. In particular, we will focus on the specific medicinal chemistry problems that were faced during the discovery of the molecules.
Rémy C, Lemoine, Jutta, Wanner
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Chemokine receptor CCR5 in interferon-treated multiple sclerosis

Acta Neurologica Scandinavica, 2007
To study the relationship between CC chemokine receptor CCR5 expression and disease activity in multiple sclerosis (MS) patients treated with beta-interferon (IFN-beta).The CCR5 Delta32 allele and a CCR5 promoter polymorphism associated with cell surface expression of CCR5 were analyzed in 109 patients with relapsing-remitting MS treated with IFN-beta ...
Sellebjerg, F, Kristiansen, Thomas Birk, Wittenhagen, P, Garred, P, Eugen-Olsen, J, Frederiksen, J L, Sørensen, Torben Lykke   +6 more
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