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The chemokine receptor CCR5 in the central nervous system
Progress in Neurobiology, 2011The expression and the role of the chemokine receptor CCR5 have been mainly studied in the context of HIV infection. However, this protein is also expressed in the brain, where it can be crucial in determining the outcome in response to different insults.
Silvia, Sorce +2 more
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Soluble chemokine CCR5 receptor is present in human plasma
Immunology Letters, 2005In view of the natural resistance to infection by HIV and occasional delayed clinical manifestation of the disease, as also the fact that the virus is able to enter only cells that express CD4 and a co-receptor, we initiated a search for a soluble co-receptor that might compete with its membrane counterpart.
Alexander, Tsimanis +2 more
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Interaction of soluble CD4 with the chemokine receptor CCR5
Biochemical and Biophysical Research Communications, 2003The chemokine receptor CCR5 is constitutively associated with the T cell co-receptor CD4 in plasma cell membranes. The CD4-CCR5 complex exhibits distinct binding properties for macrophage inflammatory protein 1beta (MIP-1beta) and enhanced G-protein signaling as compared with those of CCR5 alone.
Xiaohong, Wang, Robert, Staudinger
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Isolation and Structure of Antagonists of Chemokine Receptor (CCR5)
Journal of Natural Products, 2004Human CCR5 is a G-coupled receptor that binds to the envelope protein gp120 and CD4 and mediates the HIV-1 viral entry into the cells. The blockade of this binding by a small molecule receptor antagonist could lead to a new mode of action agent for HIV-1 and AIDS. Screening of natural product extracts led to the identification of anibamine (1), a novel
Hiranthi, Jayasuriya +14 more
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A Hammerhead Ribozyme Targeted to the Human Chemokine Receptor CCR5
Biochemical and Biophysical Research Communications, 1998The CCR5 chemokine receptor plays a crucial role in the initiation of in vivo HIV infection, acting as a critical coreceptor molecule for primary strains. Individuals with mutations in the CCR5 gene that reduce its level of expression are resistant to HIV-1 infection.
M A, González +5 more
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Pathways for internalization and recycling of the chemokine receptor CCR5
Blood, 2002AbstractM-tropic human immunodeficiency virus (HIV-1) strains enter the cell after interaction with their receptors, CD4 and the G-protein–coupled chemokine receptor CCR5. The number of cell surface CCR5 molecules is thought to be important in determining the infection rate for HIV. Cell surface CCR5 is dependent on the rate of receptor internalization
Mueller, Anja +2 more
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CC chemokine receptor 5 (CCR5) mRNA expression in pulmonary sarcoidosis
Immunology Letters, 2002The CC chemokine receptor 5 (CCR5) binds the chemokine ligands RANTES (CCL5) and MIP-1alpha (CCL3), which have been implicated in the development of alveolitis in sarcoidosis. We have, therefore, investigated CCR5 mRNA expression in bronchoalveolar lavage fluid (BALF) cells from patients with sarcoidosis.
Martin, Petrek +6 more
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