Frontiers in Immunology, 2022 The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania, the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease ...
Tirza Gabrielle Ramos de Mesquita +18 more
semanticscholar +5 more sources
Atenolol Reduces Leishmania major-Induced Hyperalgesia and TNF-α Without Affecting IL-1β or Keratinocyte Derived Chemokines (KC) [PDF]
Frontiers in Pharmacology, 2016 Infection with a high dose of the intracellular parasitic protozoan Leishmania major induces a sustained hyperalgesia in susceptible BALB/c mice accompanied by up-regulation of the pro-inflammatory cytokines IL-1β and IL-6.
Marc Karam +3 more
semanticscholar +5 more sources
Chemokines Signature and T Cell Dynamics in Leishmaniasis: Molecular insight and therapeutic application. [PDF]
Expert Rev Mol MedLeishmaniasis, caused by obligate intracellular Leishmania parasites, poses a significant global health burden. The control of Leishmania infection relies on an effective T cell-dependent immune response; however, various factors impede the host’s ...
Upadhyay S +6 more
europepmc +4 more sources
Evaluation of Chemokines MIG and IP-10 as Immunological Biomarkers of Human Visceral Leishmaniasis: A Systematic Review. [PDF]
Trop Med Infect DisVisceral leishmaniasis (VL) is a neglected tropical disease that is potentially fatal when untreated. Current diagnostic methods have limitations that contribute to ongoing transmission and poor prognosis.
Monteiro BEF +9 more
europepmc +4 more sources
Scientific Reports, 2017 Whole blood stimulation with soluble Leishmania antigen (SLA), followed by plasma cytokine and chemokine determination, provides means of detecting subjects with asymptomatic Leishmania infection.
A. Ibarra-Meneses +4 more
semanticscholar +4 more sources
Tropical Medicine and Infectious Disease, 2023 Asymptomatic Leishmania infantum, when associated with HIV, can become severe and potentially fatal. In this co-infection, the worst prognosis may be influenced by the host’s immunological aspects, which are crucial in determining susceptibility ...
Bruna Eduarda Freitas Monteiro +9 more
semanticscholar +3 more sources
Infection of Human Mononuclear Phagocytes and Macrophage‐Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor [PDF]
Scandinavian Journal of Immunology, 2003 AbstractThe expression of chemokines and chemokine receptors was studied in Leishmania donovani (LD)‐infected human mononuclear phagocytes and the human monocytic cell line THP1. Our studies showed that LD infection caused the upregulation of three β chemokines (macrophage inflammatory protein‐1 alpha (MIP‐1α), MIP‐1β and RANTES (regulated on ...
Biplab Dasgupta +5 more
semanticscholar +3 more sources
Impaired Expression of Inflammatory Cytokines and Chemokines at Early Stages of Infection with Leishmania amazonensis [PDF]
Infection and Immunity, 2003 ABSTRACTInfection of mice withLeishmania majorresults in disease progression or resolution, largely depending on the genetic backgrounds of the mouse strains. Infection withLeishmania amazonensis, on the other hand, causes progressive cutaneous lesions in most inbred strains of mice.
Jiaxiang Ji, Jiaren Sun, L. Soong
semanticscholar +3 more sources
Gamma Interferon-Regulated Chemokines in Leishmania donovani Infection in the Liver. [PDF]
Infect Immun, 2017 Murray HW, Luster AD, Zheng H, Ma X.
europepmc +2 more sources
The cytokine/chemokine response in Leishmania/HIV infection and co-infection
Heliyon, 2023 HIV infection progressively weakens the immune system by infecting and destroying cells involved in host defense. Viral infection symptoms are generated and aggravated as immunosuppression progresses, triggered by the presence of opportunistic infections: among these is leishmaniasis, a disease caused by the intracellular parasite Leishmania.
Semer Maksoud, Joelle El Hokayem
openaire +3 more sources