Results 91 to 100 of about 10,698 (195)

Infection with Leishmania major induces a cellular stress response in macrophages. [PDF]

PLoS ONE, 2014
We investigated early cellular responses induced by infection with Leishmania major in macrophages from resistant C57/BL6 mice. Infection increased production of reactive oxygen species by resident, but not inflammatory peritoneal macrophages.
Alessandra A Filardy, Ana Caroline Costa-da-Silva, Carolina M Koeller, Kamila Guimarães-Pinto, Flávia L Ribeiro-Gomes, Marcela F Lopes, Norton Heise, Célio G Freire-de-Lima, Marise P Nunes, George A DosReis   +9 more
doaj   +1 more source

Increased levels of IL-10, IL-12, and IFN-in patients with visceral leishmaniasis [PDF]

, 2009
Visceral leishmaniasis remains a serious public health problem in developing countries. Cytokines have a crucial role in the pathogenesis of this disease.
Abdolvahab, Alborz., Javadian, M.H., Khoshdel, Abolfazl., Kiany, Simin., Rosouli, Manoochehr., Taheri, Ebi.   +5 more
core   +1 more source

Vasculitis associated with Ehrlichia canis and Babesia canis in a dog in the Netherlands

Veterinary Record Case Reports, Volume 13, Issue 4, December 2025.
Abstract This report describes a case of severe, sudden‐onset, widespread vasculitis affecting a dog concurrently infected by Ehrlichia canis and Babesia canis. Following diagnostic investigations, the dog was suspected of an immune‐mediated vasculitis, possibly triggered by E. canis, B. canis or their combination. The lesions completely resolved after
Thomas Dijkxhoorn, Silvia T. Auxilia, Marie Welters, Nathalie De Vries, Margreet Ploeg   +4 more
wiley   +1 more source

Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression. [PDF]

PLoS ONE, 2017
Visceral leishmaniasis (VL), caused by infection with the intracellular protozoan Leishmania donovani, is a chronic progressive disease with a relentlessly increasing parasite burden in the spleen, liver and bone marrow.
Audrie A Medina-Colorado, Elvia Y Osorio, Omar A Saldarriaga, Bruno L Travi, Fanping Kong, Heidi Spratt, Lynn Soong, Peter C Melby   +7 more
doaj   +1 more source

Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice [PDF]

, 2016
Introduction: Liver X receptors (LXRs) are nuclear receptors that function as cholesterol sensors and regulate cholesterol homeostasis. High cholesterol has been recognized as a risk factor in asthma; however, the mechanism of this linkage is not known.
De Beuckelaer, Ans, Grooten, Johan, Gustafsson, Jan-Ake, Lambrecht, Bart, Naessens, Thomas, Smet, Muriel, Steffensen, Knut R, Van Hoecke, Lien, Vander Beken, Seppe, Vergote, Karl, Willart, Monique   +10 more
core   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
A Casadevall, A Cruz, A Glatman-Freedman, AM Cooper, AR Martineau, B Nandi, C Diveu, C Keller, CE Sutton, CG Feng, Christopher M. Sassetti, CJ Thalhofer, CY Hu, D Kitamura, DB Rawool, DJ Cua, DV Jovanovic, E Lockhart, E Marino, E Roy, E Torrado, EB Eruslanov, FE Lund, FL Ribeiro-Gomes, J Hinchey, J Pedrosa, Jiayong Xu, JL Flynn, JM Daley, Joanne L. Flynn, John Chan, JS Thorson, JU Igietseme, K Dunussi-Joannopoulos, K Hamel, KA Sweeney, Kyri Dunussi-Joannopoulos, L Desvignes, L Li, Lee Kozakiewicz, LJ Brady, M Cella, M Laan, M Zhang, MC Tsai, ML Michel, NK Damle, P Miossec, P Seiler, P Ye, PJ Maglione, PJ Maglione, PJ Maglione, PR Hamann, PS Redford, Qinglin Ou, R Appelberg, R Blomgran, R Gopal, RJ North, SA Fulton, SA Khader, ST Passos, Steven A. Porcelli, T Eddens, T Hamilton, T Korn, T Matsushita, TK Kondratieva, W Ouyang, William R. Jacobs, X Zhang, Y Ito, Yanhua Wang, Yong Chen   +74 more
core   +6 more sources

Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential

MedComm, Volume 6, Issue 11, November 2025.
This review systematically summarizes dendritic cells (DCs) originating from hematopoietic stem cells, their major subsets (cDC1s, cDC2s, pDCs, moDCs, LCs) and core functions (antigen capture/presentation, adaptive immunity activation, immune tolerance induction, and regulation of innate immune cells).
Fangfang Jin, Lingxiang Xie, Hongqi Zhang, Xiang Fan, Jiaxing Tian, Wei Liu, Yang Xiao, Xinrong Fan   +7 more
wiley   +1 more source

Evidence for involvement of Th17 type responses in post kala azar dermal leishmaniasis (PKDL). [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Post kala-azar dermal leishmaniasis (PKDL), a dermal sequel of visceral leishmaniasis, caused by Leishmania donovani, constitutes an important reservoir for the parasite.
Gajendra Kumar Katara, Nasim Akhtar Ansari, Avninder Singh, V Ramesh, Poonam Salotra   +4 more
doaj   +1 more source

Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation

Immunological Reviews, Volume 336, Issue 1, November 2025.
ABSTRACT Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immunity by presenting antigens to prime antigen‐specific T cells. Conventional DC (cDC) type 2 cells (cDC2s) are a phenotypically heterogeneous population of DCs highly capable of presenting antigens to CD4+ T cells.
Naoya Tatsumi, Ariel Tjitropranoto, Alejandro Davila‐Pagan, Yosuke Kumamoto   +3 more
wiley   +1 more source

Emerging Role of Splenic Macrophage in Malaria Pathogenesis and Immunity

Immunity, Inflammation and Disease, Volume 13, Issue 10, October 2025.
ABSTRACT Background Malaria, caused by Plasmodium parasites, remains a leading global health concern, impacting millions of people globally. Splenic macrophages are specialized immune cells that reside in the spleen and play a pivotal role in the pathogenesis and immune response during malaria.
Aarti Gupta, Meenu Kalkal, Jyoti Das
wiley   +1 more source