Dendritic cells steering antigen and leukocyte traffic in lymph nodes
FEBS Letters, Volume 599, Issue 14, Page 2048-2059, July 2025.Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta +3 more
wiley +1 more source
Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection [PDF]
, 2015 Bioactive matrix fragments (matrikines) have been identified in a myriad of disorders, but their impact on the evolution of airway inflammation has not been demonstrated.
Snelgrove, RJ
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Clinical and Developmental Immunology, 2012 Leishmania major-infected TNF receptor 1 deficient (TNFR1 KO) mice resolve parasitism but fail to resolve lesions, while wild-type mice completely heal. We investigated the cell composition, cytokine production, and apoptosis in lesions from L.
Carolina Ferreira Oliveira +10 more
doaj +1 more source
Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis. [PDF]
, 2017 The presence of the endogenous <i>Leishmania</i> RNA virus 1 (LRV1) replicating stably within some parasite species has been associated with the development of more severe forms of leishmaniasis and relapses after drug treatment in humans ...
Beverley, S.M. +12 more
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Immunopathology of Leishmaniasis: an update. [PDF]
, 2007 Leishmaniasis represents a severe, increasing, public health problem. The perspective of its control is highly dependent on research progress, on therapeutic manipulations of the immune system, and on vaccine development.
Cillari, E. +5 more
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Journal of Immunology Research, 2020 Visceral leishmaniasis (VL) is a lethal disease if left untreated. Current treatments produce variable rates of treatment failure and toxicity without sterile cure, rendering treatment efficacy monitoring essential.
Yetemwork Aleka +11 more
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Inflammation-induced effector CD4+ T cell interstitial migration is alpha-v integrin dependent [PDF]
, 2014 Leukocytes must traverse inflamed tissues to effectively control local infection. Although motility in dense tissues appears to be integrin-independent actin-myosin based, during inflammation changes to the extracellular matrix (ECM) may necessitate ...
Acharya, Mridu +14 more
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Innate Immunity Plays a Key Role in Leishmania Infection: Implications for Vaccine Design
Journal of Medical Microbiology and Infectious Diseases, 2016 Neutrophils are part of the first line of immune response and are essential for resistance against a variety of pathogens. They professionally mediate direct killing of pathogens, recruit other phagocytes by specific chemokines, produce cytokines and ...
Negar Seyed, Sima Rafati
doaj
Importance of CD8 T cell-mediated immune response during intracellular parasitic infections and its implications for the development of effective vaccines [PDF]
, 2003 Obligatory intracellular parasites such as Plasmodium sp, Trypanosoma cruzi, Toxoplasma gondii and Leishmania sp are responsible for the infection of hundreds of millions of individuals every year.
Boscardin, Silvia Beatriz +5 more
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Effect of IL-22 on DNA vaccine encoding LACK gene of Leishmania major in BALB/c mice
, 2013 In the present study, the effect of IL-22 together with the plasmid encoding LACK (Leishmania homolog of receptors for activated C-kinase) gene of Leishmania major on the trend of leishmaniasis in BALB/c mice was evaluated.Evaluation of the cellular and ...
Dalimi, A. +4 more
core +1 more source