Results 11 to 20 of about 10,698 (195)

Human Chemokines as Antimicrobial Peptides with Direct Parasiticidal Effect on Leishmania mexicana In Vitro [PDF]

PLoS ONE, 2013
Chemokines and chemokine receptor-mediated effects are important mediators of the immunological response and cure in human leishmaniasis. However, in addition to their signalling properties for leukocytes, many chemokines have also been shown to act ...
S. K. Söbirk, M. Mörgelin, A. Egesten, P. Bates, O. Shannon, M. Collin   +5 more
semanticscholar   +2 more sources

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

Frontiers in Immunology, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +7 more sources

The Use of an Adjuvant System Improves Innate and Adaptive Immune Response When Associated with a Leishmania (Viannia) braziliensis Antigen in a Vaccine Candidate against L. (Leishmania) infantum Infection

Vaccines, 2023
Background: The adjuvants’ optimal dose and the administration route can directly influence the epitope recognition patterns and profiles of innate response.
F. A. S. Mathias, T. Ostolin, L. E. S. Reis, J. M. Cardoso, R. D. De Brito, Rodrigo Dian Oliveira Aguiar Soares, B. Roatt, P. Vieira, A. B. Reis   +8 more
semanticscholar   +3 more sources

Protection and Pathology in Leishmania braziliensis Infection

Pathogens, 2022
Leishmania killing is mediated by IFN-γ-activated macrophages, but IFN-γ production and macrophage activation are insufficient to control L. braziliensis infection.
A. Carvalho, O. Bacellar, E. Carvalho
semanticscholar   +3 more sources

Leishmania amazonensis Promastigotes or Extracellular Vesicles Modulate B-1 Cell Activation and Differentiation

Frontiers in Cellular and Infection Microbiology, 2020
B-1 cells are considered an innate-like B cell population that participates in effective innate and adaptive responses to pathogens. B-1 cells produce immunoglobulins, cytokines, chemokines, migrate to inflammatory sites, and differentiate into ...
Natasha Ferraz dos Campos Reis, T. Dupin, C. R. Costa, M. Toledo, V. C. de Oliveira, A. Popi, A. Torrecilhas, P. Xander   +7 more
semanticscholar   +3 more sources

Genetics of Host Response to Leishmania tropica in Mice – Different Control of Skin Pathology, Chemokine Reaction, and Invasion into Spleen and Liver [PDF]

PLoS Neglected Tropical Diseases, 2012
Leishmaniasis is a disease caused by protozoan parasites of genus Leishmania. The frequent involvement of Leishmania tropica in human leishmaniasis has been recognized only recently. Similarly as L. major, L. tropica causes cutaneous leishmaniasis in humans, but can also visceralize and cause systemic illness. The relationship between the host genotype
Kobets, T. (Tetyana), Havelková, H. (Helena), Grekov, I. (Igor), Volkova, V. (Valeriya), Vojtíšková, J. (Jarmila), Slapničková, M. (Martina), Kurey, I. (Irina), Sohrabi, Y. (Yahya), Svobodová, M., Demant, P., Lipoldová, M. (Marie)   +10 more
openaire   +5 more sources

Immunity to LuloHya and Lundep, the salivary spreading factors from Lutzomyia longipalpis, protects against Leishmania major infection

PLoS Pathogens, 2018
Salivary components from disease vectors help arthropods to acquire blood and have been shown to enhance pathogen transmission in different model systems.
Inés Martín-Martín, A. Chagas, Anderson B. Guimarães-Costa, L. Amo, Fabiano Oliveira, Ian N. Moore, Thiago DeSouza-Vieira, E. Sánchez, M. Suntravat, J. Valenzuela, J. Ribeiro, E. Calvo   +11 more
semanticscholar   +2 more sources

Leishmania Specific CD4 T Cells Release IFNγ That Limits Parasite Replication in Patients with Visceral Leishmaniasis [PDF]

PLoS Neglected Tropical Diseases, 2014
Visceral leishmaniasis (VL) is associated with increased circulating levels of multiple pro-inflammatory cytokines and chemokines, including IL-12, IFNγ, and TNFα, and elevated expression of IFNγ mRNA in lesional tissue such as the spleen and bone marrow.
R. Kumar, Neetu Singh, S. Gautam, O. Singh, K. Gidwani, Madhukar Rai, D. Sacks, S. Sundar, S. Nylén   +8 more
semanticscholar   +2 more sources

Protection mediated by chemokine CXCL10 in BALB/c mice infected by Leishmania infantum

Memorias do Instituto Oswaldo Cruz, 2017
BACKGROUND Visceral leishmaniasis (VL) caused by Leishmania infantum is characterised by the loss of the ability of the host to generate an effective immune response.
Webertty Mayk Eufrásio de Figueirêdo, S. M. Viana, Dorotheia Teixeira Alves, P. Guerra, Z. C. B. Coêlho, H. S. Barbosa, M. Teixeira   +6 more
semanticscholar   +3 more sources

Mechanisms of Immune Evasion, Dissemination, and Persistence in Leishmania amazonensis Infection. [PDF]

Parasite Immunol
ABSTRACT Leishmania amazonensis is one of the etiological agents of cutaneous leishmaniasis in its localised form. Moreover, this parasite can cause more severe disease conditions, such as diffuse and disseminated cutaneous leishmaniasis. The development of more severe clinical manifestations is associated with the parasite's ability to establish a ...
Portugal AB, DaMatta RA, da Cunha Júnior EF, Wanderley JLM.   +3 more
europepmc   +2 more sources