Results 21 to 30 of about 10,698 (195)

Sex in Immune Cells and Parasitic Diseases - A Complex Relationship. [PDF]

Immunol Rev
ABSTRACT Epidemiological studies consistently show that many parasitic diseases affect males more frequently than females. These disparities are multifactorial, arising partly from gender‐specific behaviors that influence exposure risk and health‐seeking practices, especially in low‐ and middle‐income countries. Increasing evidence also highlights that
Honecker B, Hansen CS, Lotter H.
europepmc   +2 more sources

Transcriptional Analysis of Human Skin Lesions Identifies Tryptophan-2,3-Deoxygenase as a Restriction Factor for Cutaneous Leishmania

Frontiers in Cellular and Infection Microbiology, 2019
Disease manifestation after infection with cutaneous Leishmania species is the result of a complex interplay of diverse factors, including the immune status of the host, the infecting parasite species, or the parasite load at the lesion site ...
V. Rodrigues, Sónia André, H. Maksouri, Tarik Mouttaki, S. Chiheb, M. Riyad, K. Akarid, J. Estaquier   +7 more
semanticscholar   +3 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]

J Trop Med
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc   +2 more sources

Bidirectional cytokine-microRNA control: A novel immunoregulatory framework in leishmaniasis

PLoS Pathogens, 2022
As effector innate immune cells and as a host to the protozoan parasite Leishmania, macrophages play a dual role in antileishmanial immunoregulation.
Abdollah Jafarzadeh, Maryam Nemati, Najmeh Aminizadeh, Neelam Bodhale, Arup Sarkar, Sara Jafarzadeh, Iraj Sharifi, Bhaskar Saha   +7 more
doaj   +2 more sources

The role of Leishmania GP63 in the modulation of innate inflammatory response to Leishmania major infection.

PLoS ONE, 2021
Leishmaniasis is a disease caused by the protozoan parasite Leishmania and is known to affect millions of individuals worldwide. In recent years, we have established the critical role played by Leishmania zinc-metalloprotease GP63 in the modulation of ...
Aretha Chan, Jose-Mauricio Ayala, Fernando Alvarez, Ciriaco Piccirillo, George Dong, David Langlais, Martin Olivier   +6 more
doaj   +2 more sources

Leishmania majorModulates Chemokine and Chemokine Receptor Expression by Dendritic Cells and Affects Their Migratory Capacity [PDF]

Infection and Immunity, 2005
ABSTRACTDendritic cells (DC) both produce and respond to chemokines. We examined the profiles of chemokines and chemokine receptors expressed by DC and their chemotactic response after interaction withLeishmania major. Expression of the chemokine receptors CCR2 and CCR5 by DC and their responsiveness to the respective ligands, CCL2 and CCL3, were ...
Mario, Steigerwald, Heidrun, Moll
openaire   +2 more sources

Naturally Leishmania infantum-infected dogs display an overall impairment of chemokine and chemokine receptor expression during visceral leishmaniasis [PDF]

Veterinary Immunology and Immunopathology, 2013
Dogs are the primary reservoir for Leishmania parasites. The immune response induced by Leishmania infantum infection in these animals has not been completely elucidated, and few studies have investigated the relationship between the expression levels of chemokines and chemokine receptors and the clinical status of dogs with canine visceral ...
Manuela S L, Nascimento, Talyta D R, Albuquerque, Maria A, Do-Valle-Matta, Ivo S, Caldas, Lívia F, Diniz, André, Talvani, Maria T, Bahia, Cléber M, Andrade, Lúcia M C, Galvão, Antônia C J, Câmara, Paulo M M, Guedes   +10 more
openaire   +2 more sources

Leishmania Promastigotes Enhance Neutrophil Recruitment through the Production of CXCL8 by Endothelial Cells

Pathogens, 2021
Endothelial cells represent one of the first cell types encountered by Leishmania promastigotes when inoculated into the skin of the human hosts by the bite of phlebotomine sand flies.
Sarah D’Alessandro, Silvia Parapini, Yolanda Corbett, Roberta Frigerio, Serena Delbue, Annalisa Modenese, Marina Gramiccia, Pasquale Ferrante, Donatella Taramelli, Nicoletta Basilico   +9 more
doaj   +1 more source

Chemokine Gene Expression in Toll-Like Receptor-Competent and -Deficient Mice Infected with Leishmania major [PDF]

Infection and Immunity, 2004
ABSTRACT We studied the expression of a subset of chemokines, including RANTES/CCL5, MIP-1α/CCL3, IP-10/CXCL10, and MCP-1/CCL2, in Toll-like receptor (TLR)-competent and -deficient mice after infection with Leishmania major .
Antoniazi, S., Price, H., Kropf, P., Freudenberg, M., Galanos, C., Smith, D., Müller, I.   +6 more
openaire   +3 more sources

Leishmania infantum amastigotes enhance HIV-1 production in cocultures of human dendritic cells and CD4 T cells by inducing secretion of IL-6 and TNF-alpha. [PDF]

PLoS Neglected Tropical Diseases, 2009
Visceral leishmaniasis has emerged as an important opportunistic disease among patients infected with HIV-1. Both HIV-1 and the protozoan parasite Leishmania can productively infect cells of the macrophage-dendritic cell lineage.Here we demonstrate that ...
Ravendra Garg, Corinne Barat, Michel Ouellet, Robert Lodge, Michel J Tremblay   +4 more
doaj   +1 more source