Results 31 to 40 of about 10,698 (195)

LeishmaniaInfection Impairs β₁-Integrin Function and Chemokine Receptor Expression in Mononuclear Phagocytes [PDF]

Infection and Immunity, 2006
ABSTRACTLeishmaniaspp. are intracellular parasites that cause lesions in the skin, mucosa, and viscera. We have previously shown thatLeishmaniainfection reduces mononuclear phagocyte adhesion to inflamed connective tissue. In this study, we examined the role of adhesion molecules and chemokines in this process.
Nathanael F, Pinheiro, Micely D R, Hermida, Mariana P, Macedo, José, Mengel, Andre, Bafica, Washington L C, dos-Santos   +5 more
openaire   +2 more sources

Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction. [PDF]

PLoS Pathog
Sex-based differences in the immune system influence the clinical course of infectious diseases, including many parasitic infections. Field studies of human infections and controlled experimental rodent models have shown that certain clinical forms of ...
Bea A, Fehling H, Hausmann F, Habib FM, Lütkemeyer M, Buer L, Schäfer C, Hansen CS, Honecker B, Bonn S, Schneider BE, Clos J, Lotter H.   +12 more
europepmc   +2 more sources

Leishmania infection and neuroinflammation: Specific chemokine profile and absence of parasites in the brain of naturally-infected dogs [PDF]

Journal of Neuroimmunology, 2015
Visceral leishmaniasis is a chronic disease caused by Leishmania infantum. We aimed to detect the parasite in the brain of fifteen naturally-infected dogs using in situ hybridization and immunohistochemistry, and the gene expression of selected chemokines by RT-qPCR.
Melo, Guilherme D., Silva, José Eduardo S., Grano, Fernanda G., Souza, Milena S., Machado, Gisele F.   +4 more
openaire   +3 more sources

Visceral leishmaniasis patients display altered composition and maturity of neutrophils as well as impaired neutrophil effector functions [PDF]

, 2016
Immunologically, active visceral leishmaniasis (VL) is characterised by profound immunosuppression, severe systemic inflammatory responses and an impaired capacity to control parasite replication.
Adem, E, Cruz Cervera, E, Diro, E, Getahun, M, Hailu, A, Kropf, P, Lemma, M, Melkamu, R, Mengesha, B, Mesfin, G, Modolell, M, Muller, I, Munder, M, Skhedy, Z, Tajebe, F, Takele, Y, Van der Auwera, G, Yardley, V, Yeshanew, A, Yizengaw, E   +19 more
core   +6 more sources

Leishmania-induced inactivation of the macrophage transcription factor AP-1 is mediated by the parasite metalloprotease GP63. [PDF]

PLoS Pathogens, 2010
Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and ...
Irazú Contreras, María Adelaida Gómez, Oliver Nguyen, Marina T Shio, Robert W McMaster, Martin Olivier   +5 more
doaj   +1 more source

Insight Into the Long Noncoding RNA and mRNA Coexpression Profile in the Human Blood Transcriptome Upon Leishmania infantum Infection

Frontiers in Immunology, 2022
Visceral leishmaniasis (VL) is a vector-borne infectious disease that can be potentially fatal if left untreated. In Brazil, it is caused by Leishmania infantum parasites. Blood transcriptomics allows us to assess the molecular mechanisms involved in the
S. Maruyama, C. Fuzo, A. E. Oliveira, L. A. Rogerio, N. T. Takamiya, Gabriela Pessenda, E. D. de Melo, A. M. Da Silva, A. R. Jesus, Vanessa Carregaro, H. Nakaya, R. Almeida, J. S. da Silva   +12 more
semanticscholar   +1 more source

Yin and yang of interleukin-17 in host immunity to infection [version 1; referees: 2 approved] [PDF]

, 2017
The interleukin-17 (IL-17) family cytokines, such as IL-17A and IL-17F, play important protective roles in host immune response to a variety of infections such as bacterial, fungal, parasitic, and viral.
Das, Shibali, Khader, Shabaana
core   +3 more sources

Interferon-gamma in leishmaniasis.

Frontiers in Immunology, 2013
Leishmaniasis is a complex disease that is caused by parasites of the Leishmania genus. Leishmania are further classified into several complexes, each of which can engage in distinct interactions with mammalian hosts resulting in differing disease ...
Peter Epeh Kima, Lynn eSoong
doaj   +1 more source

Leishmania Major Centrin Gene-Deleted Parasites Generate Skin Resident Memory T-Cell Immune Response Analogous to Leishmanization

Frontiers in Immunology, 2022
Leishmaniasis is a vector-borne parasitic disease transmitted through the bite of a sand fly with no available vaccine for humans. Recently, we have developed a live attenuated Leishmania major centrin gene-deleted parasite strain (LmCen-/- ) that ...
Nevien Ismail, S. Karmakar, P. Bhattacharya, Telly Sepahpour, K. Takeda, S. Hamano, G. Matlashewski, A. Satoskar, Sreenivas Gannavaram, R. Dey, H. Nakhasi   +10 more
semanticscholar   +1 more source

Pathogen Evasion of Chemokine Response Through Suppression of CXCL10

Frontiers in Cellular and Infection Microbiology, 2019
Clearance of intracellular pathogens, such as Leishmania (L.) major, depends on an immune response with well-regulated cytokine signaling. Here we describe a pathogen-mediated mechanism of evading CXCL10, a chemokine with diverse antimicrobial functions,
Alejandro L. Antonia, Kyle D. Gibbs, Esme D. Trahair, Kelly J. Pittman, Amelia T. Martin, Benjamin H. Schott, Jeffrey S. Smith, Sudarshan Rajagopal, Sudarshan Rajagopal, J. Will Thompson, Richard Lee Reinhardt, Richard Lee Reinhardt, Dennis C. Ko, Dennis C. Ko   +13 more
doaj   +1 more source