Results 41 to 50 of about 10,698 (195)

Insights on adaptive and innate immunity in canine leishmaniosis [PDF]

, 2016
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah, Alexander, Catchpole, DAMER P. BLAKE, de Souza Carmo, Green, Kensil, LAIA SOLANO-GALLEGO, Lopez, Margarito, Ordeix, Pinelli, Pitta, Quinnell, Sadick, Sanchez, SHAZIA HOSEIN, Silva, Vouldoukis, Wakelin   +19 more
core   +4 more sources

Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8

PLOS Neglected Tropical Diseases, 2021
Leishmaniaare intracellular protozoan parasites that cause a wide spectrum of clinical manifestations in genetically susceptible individuals with an insufficient or balanced Th1 immune response to eliminate the parasite. MiRNAs play important regulatory role in numerous biological processes including essential cellular functions.
Tirza Gabrielle Ramos de Mesquita, José do Espírito Santo Junior, Thais Carneiro de Lacerda, Krys Layane Guimarães Duarte Queiroz, Cláudio Marcello da Silveira Júnior, José Pereira de Moura Neto, Lissianne Augusta Matos Gomes, Mara Lúcia Gomes de Souza, Marcus Vinitius de Farias Guerra, Rajendranath Ramasawmy   +9 more
openaire   +4 more sources

Suppression of LPS-induced inflammatory responses in macrophages infected with Leishmania

Journal of Inflammation, 2010
Background Chronic inflammation activated by macrophage innate pathogen recognition receptors such as TLR4 can lead to a range of inflammatory diseases, including atherosclerosis, Crohn's disease, arthritis and cancer.
Kelly Ben L, Lapara Nicholas J
doaj   +1 more source

In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13

Brazilian Journal of Infectious Diseases, 2010
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production.
Zirlane Castelo B. Coêlho, Maria Jania Teixeira, Erika Freitas Mota, Mércia Sindeaux Frutuoso, João Santana da Silva, Aldina Barral, Manoel Barral-Netto, Margarida Maria L. Pompeu   +7 more
doaj   +1 more source

An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice [PDF]

, 2011
Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection.
Barth, Thomas, Botteron, Catherine, Lechner, Anja, Männel, Daniela N., Nguyen, Trang T. T., Ritter, Uwe, Schmidt, Dominic   +6 more
core   +7 more sources

Inhibitor of serine peptidase 2 enhances Leishmania major survival in the skin through control of monocytes and monocyte-derived cells [PDF]

, 2017
Leishmania major is the causative agent of the neglected tropical disease, cutaneous leishmaniasis. In the mouse, protective immunity to Leishmania is associated with inflammatory responses.
Amy Goundry, Ana Paula C. A. Lima, Audrey Romano, Chung C. H., Elmarie Myburgh, Jeremy C. Mottram, Petritus P. M., Sacks D. L., Schuster S., Svensjö E.   +9 more
core   +2 more sources

Macrophages participate in host protection and the disease pathology associated with Leishmania braziliensis infection

BMC Infectious Diseases, 2012
Background Leishmania preferentially infects macrophages, which allow the parasite to multiply but can also kill the parasite. Although the T cell response in human leishmaniasis is well-characterized, little is known about the concomitant macrophage ...
Giudice Angela, Vendrame Célia, Bezerra Caroline, Carvalho Lucas P, Delavechia Thaís, Carvalho Edgar M, Bacellar Olívia   +6 more
doaj   +1 more source

Modulation of Macrophage Redox and Apoptotic Processes to Leishmania infantum during Coinfection with the Tick-Borne Bacteria Borrelia burgdorferi

Pathogens, 2023
Canine leishmaniosis (CanL) is a zoonotic disease caused by protozoan Leishmania infantum. Dogs with CanL are often coinfected with tick-borne bacterial pathogens, including Borrelia burgdorferi in the United States. These coinfections have been causally
Danielle Pessôa-Pereira, Breanna M. Scorza, Karen I. Cyndari, Erin A. Beasley, Christine A. Petersen   +4 more
doaj   +1 more source

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource [PDF]

, 2015
Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e.
Alonso-Padilla, Julio, Alvarez, Emilio, Bardera, Ana I., Barroso, Vanessa, Brown, James R., Cantizani, Juan, Colmenarejo, Gonzalo, Cotillo, Ignacio, de Dios-Anton, Francisco, Drewry, David H., Fiandor, Jose M., Gray, David W., Julio Martin, J., Kessler, Albane, Kumar, Vinod, Navarro, Miguel, Peña, Imanol, Pilar Manzano, M., Rodriguez, Ana, Roquero, Irene, Sherstnev, Alexander   +20 more
core   +3 more sources

Interleukin-12 p40 secretion by cutaneous CD11c(+) and F4/80(+) cells is a major feature of the innate immune response in mice that develop Th1-mediated protective immunity to Schistosoma mansoni [PDF]

, 2003
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson, S, Hogg, K G, Kumkate, S, Mountford, A P   +3 more
core   +2 more sources