Results 61 to 70 of about 10,698 (195)

Asymptomatic immune responders to Leishmania among HIV positive patients.

PLoS Neglected Tropical Diseases, 2019
Concomitant infection with human immunodeficiency virus (HIV) and the Leishmania parasite is a growing public health problem, the result of the former spreading to areas where the latter is endemic.
Laura Botana, Ana Victoria Ibarra-Meneses, Carmen Sánchez, Alicia Castro, Juan Victor San Martin, Laura Molina, Jose Manuel Ruiz-Giardin, Eugenia Carrillo, Javier Moreno   +8 more
doaj   +1 more source

Building Confidence in Quantitative Systems Pharmacology Models : An Engineer's Guide to Exploring the Rationale in Model Design and Development [PDF]

, 2016
This tutorial promotes good practice for exploring the rationale of systems pharmacology models. A safety systems engineering inspired notation approach provides much needed rigor and transparency in development and application of models for therapeutic ...
Albergante, Alden, Alden, Alden, Alden, Alvar, An, An, Barnes, Cilfone, Combining software evidence arguments and assurance, Fenn, Gazzinelli, Grimm, Guo, Hayden, Ince, Joppa, Kane, Kaye, McCall, McKay, Murray, Polack, Read, Rosenberg, Verma, Vinken   +27 more
core   +1 more source

Effects of Leishmania donovani Cathepsin B on the production of cytokines and chemokines by macrophages

, 2021
Leishmania cysteine proteases are important virulence factors involved in host-parasite interaction. Previous studies revealed an important role for cysteine proteases in modulation of the T helper cell responses through interfering with macrophage functions or by targeting certain immune modulators for degradation.
openaire   +2 more sources

Regulation of immunity during visceral Leishmania infection [PDF]

, 2016
Unicellular eukaryotes of the genus Leishmania are collectively responsible for a heterogeneous group of diseases known as leishmaniasis. The visceral form of leishmaniasis, caused by L. donovani or L.
A Caldas, A Campos-Neto, A Cope, A Gallimore, A Hammami, A Maroof, A Maroof, A Nieto, A Schietinger, AC Ghose, AC Stanley, AC Stanley, AJ Zajac, AM Mangoud, Anabela Cordeiro-da-Silva, AP Freitas do Rosario, B Galvao-Castro, BM Owens, BN Thomas, BT Edelson, BT Edelson, C Trez De, C Zaph, CR Engwerda, CR Engwerda, CR Engwerda, CR Engwerda, CR Engwerda, CR Engwerda, D Jankovic, D Nandan, DA Vignali, DL Sacks, DR Faria, E Cillari, EJ Wherry, EJ Wherry, EM Carvalho, F Chappuis, F Real, F Robert-Gangneux, F Woelbing, FO Novais, G Arango Duque, G Matlashewski, GD Victora, GR Cooper, H Aslan, HT Jin, HT Jin, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, HW Murray, I Muller, I Muller, I Vouldoukis, J Alvar, J Chavas, J Griensven van, J Lehmann, J Zhu, JE Dalton, JG Cyster, JJ Stern, JL Amprey, JP Gigley, JS Cervia, JS Yi, JW Moore, Jérôme Estaquier, K Ghosh, KE Squires, KJ Esch, KN Gibson-Corley, KN Gibson-Corley, L Beattie, L Beattie, L Beattie, LE Rosas, LE Rosas, LE Smith, LU Buxbaum, M Ato, M Barral-Netto, M Guilliams, M Olivier, M Resende, M Saraiva, M Svensson, M Svensson, MA Nolte, MC Cumont, MC Tumang, ME Wilson, ME Wilson, MG Pitta, Mireille Laforge, MJ McElrath, ML Murphy, ML Murphy, MM Kane, MS Nascimento, N Rolao, N Santarem, NA Ansari, NA Gomes, ND Glennie, OP Singh, OP Singh, P Gallo, P Kaye, P Tsagozis, P Tsagozis, P Yurdakul, PA Kager, PM Gorak, PM Kaye, PT Bunn, R Badaro, R Bankoti, R Kumar, R Phillips, R Polley, R Polley, R Polley, R Porrozzi, RD Pearson, RE Mebius, Ricardo Silvestre, RJ Faleiro, RT Kenney, S Bhattacharyya, S Crotty, S Gautam, S Gautam, S Honore, S Ito, S Karmakar, S Kaur, S Lopez Kostka, S Nakayamada, S Nylen, S Nylen, S Oghumu, S Santos Cda, S Stager, S Stager, SA Costa Lima, SA Miles, SC Smelt, SC Smelt, SE Cotterell, SL Colpitts, SM Kaech, T Joshi, V Diniz-Atayde, V Leclercq, V Peruhype-Magalhaes, V Rodrigues, Vasco Rodrigues, VL Matta da, W Ouyang, WE Agu, WG Shreffler, Y Belkaid   +170 more
core   +5 more sources

Genetics, Transcriptomics and Meta-Taxonomics in Visceral Leishmaniasis

Frontiers in Cellular and Infection Microbiology, 2020
Visceral leishmaniasis (VL) caused by parasites of the Leishmania donovani complex can be fatal in susceptible individuals. Understanding the interactions between host and pathogen is one way to obtain leads to develop better drugs and for vaccine ...
Jenefer M. Blackwell, Michaela Fakiola, Om Prakash Singh, Om Prakash Singh   +3 more
doaj   +1 more source

CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. [PDF]

, 2010
BACKGROUND: L. braziliensis causes cutaneous (CL) and mucosal (ML) leishmaniasis. Wound healing neutrophil (PMN) and macrophage responses made following the bite of the vector sand fly contribute to disease progression in mice.
Blackwell, Jenefer M, Carvalho, Edgar M, Castellucci, Léa, de Jesus, Amélia Ribeiro, Guimarães, Luiz Henrique, Jamieson, Sarra E, Lessa, Marcus, Magalhães, Andrea, Menezes, Eliane, Miller, E Nancy, Oliveira, Joyce   +10 more
core   +3 more sources

Molecular signatures of anthroponotic cutaneous leishmaniasis in the lesions of patients infected with Leishmania tropica

Scientific Reports, 2020
Anthroponotic cutaneous leishmaniasis (CL) caused by Leishmania tropica (L. tropica) represents a public health challenge in several resource poor settings.
Nasrin Masoudzadeh, Malin Östensson, J. Persson, Vahid Mashayekhi Goyonlo, Christopher Agbajogu, Y. Taslimi, Reza Erfanian Salim, F. Zahedifard, A. Mizbani, Housein Malekafzali Ardekani, B. Gunn, S. Rafati, A. Harandi   +12 more
semanticscholar   +1 more source

Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe, Tamara Zoran, Marylyn Martina Addo   +2 more
wiley   +1 more source

IFN-γ production to leishmania antigen supplements the leishmania skin test in identifying exposure to L. braziliensis infection.

PLoS Neglected Tropical Diseases, 2012
BackgroundCutaneous leishmaniasis due to L. braziliensis (CL) is characterized by a positive delayed type hypersensitivity test (DTH) leishmania skin test (LST) and high IFN-γ production to soluble leishmania antigen (SLA).
Daniel Schnorr, Aline C Muniz, Sara Passos, Luiz H Guimaraes, Ednaldo L Lago, Olívia Bacellar, Marshall J Glesby, Edgar M Carvalho   +7 more
doaj   +1 more source

The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination [PDF]

, 2018
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses.
Gray, Joshua I., Macleod, Megan K.L., Westerhof, Lotus   +2 more
core   +1 more source