Results 71 to 80 of about 10,698 (195)

Twin Attributes of Tyrosyl-tRNA Synthetase of Leishmania donovani: A HOUSEKEEPING PROTEIN TRANSLATION ENZYME AND A MIMIC OF HOST CHEMOKINE.

The Journal of biological chemistry, 2017
Aminoacyl-tRNA synthetases (aaRSs) are housekeeping enzymes essential for protein synthesis. Apart from their parent aminoacylation activity, several aaRSs perform non-canonical functions in diverse biological processes. The present study explores the twin attributes of Leishmania tyrosyl-tRNA synthetase (LdTyrRS) namely, aminoacylation, and as a mimic
Sneha, Anand, Rentala, Madhubala
openaire   +2 more sources

Sertraline Delivered in Phosphatidylserine Liposomes Is Effective in an Experimental Model of Visceral Leishmaniasis [PDF]

, 2019
Liposomes containing phosphatidylserine (PS) has been used for the delivery of drugs into the intramacrophage milieu. Leishmania (L.) infantum parasites live inside macrophages and cause a fatal and neglected viscerotropic disease, with a toxic treatment.
Allen, Alvar, Andrade-Neto, Andrews, Ansari, Botero, Buffet, Carnielli, Carvalheiro, Chakravarty, Chan, Costa-Silva, Costa-Silva, Cotterell, Croft, Croft, Cunha-Júnior, Deshmane, Dey, Dhanikula, Ellis, Evans, Faleiro, Furtado, Guerra, Huang, Kansal, Kreilgaard, Lamy, Laverman, Lima, Lindoso, Lourie, Mattock, Mikus, Mukherjee, Mukherjee, Murdoch, Murray, Onaolapo, Ong, Ostrosky-Zeichner, Palit, Park, Pinto, Reagan-Shaw, Rebello, Reimão, Richardson, Ronfeld, Santuzzi, Stewart, Tempone, Tempone, Tempone, Tsushima, Walton, Yardley   +57 more
core   +2 more sources

Identification of asymptomatic Leishmania infection in patients undergoing kidney transplant using multiple tests

International Journal of Infectious Diseases
Objectives: In immunocompromised patients, asymptomatic Leishmania infection can reactivate, and evolve to severe disease. To date, no test is considered the gold standard for the identification of asymptomatic Leishmania infection.
Alessandro Deni, Alessandra Mistral De Pascali, Margherita Ortalli, Emma Balducelli, Michele Provenzano, Francesca Ferrara, Marco Busutti, Gaetano La Manna, Lorenzo Zammarchi, Alessandro Bartoloni, Leonardo Caroti, Ana Victoria Ibarra-Meneses, Eugenia Carrillo, Giorgia Comai, Stefania Varani   +14 more
doaj   +1 more source

Invariant NKT cells drive hepatic cytokinic microenvironment favoring efficient granuloma formation and early control of Leishmania donovani infection. [PDF]

PLoS ONE, 2012
The development of inflammatory granulomas around infected Kupffer cells is necessary for hepatic parasite clearance during visceral leishmaniasis. Invariant NKT (iNKT) cells are predominant T cells in the mouse liver and can synthesize large quantities ...
Florence Robert-Gangneux, Anne-Sophie Drogoul, Octavie Rostan, Claire Piquet-Pellorce, Jérome Cayon, Mariette Lisbonne, André Herbelin, Hugues Gascan, Claude Guiguen, Michel Samson, Jean-Pierre Gangneux   +10 more
doaj   +1 more source

miR-548d-3p Is Up-Regulated in Human Visceral Leishmaniasis and Suppresses Parasite Growth in Macrophages

Frontiers in Cellular and Infection Microbiology, 2022
Visceral leishmaniasis caused by Leishmania (Leishmania) infantum in Latin America progress with hepatosplenomegaly, pancytopenia, hypergammaglobulinemia, and weight loss and maybe lethal mainly in untreated cases.
Eduardo Milton Ramos-Sanchez, Eduardo Milton Ramos-Sanchez, Eduardo Milton Ramos-Sanchez, Luiza Campos Reis, Marina de Assis Souza, Sandra Márcia Muxel, Kamila Reis Santos, Dimitris Lagos, Valéria Rêgo Alves Pereira, Maria Edileuza Felinto de Brito, Paul Martin Kaye, Lucile Maria Floeter-Winter, Hiro Goto, Hiro Goto   +13 more
doaj   +1 more source

Gastropod-derived haemocyte extracellular traps entrap metastrongyloid larval stages of Angiostrongylus vasorum, Aelurostrongylus abstrusus and Troglostrongylus brevior [PDF]

, 2017
Background: Phagocyte-derived extracellular traps (ETs) were recently demonstrated mainly in vertebrate hosts as an important effector mechanism against invading parasites.
Gärtner, Ulrich, Hermosilla, Carlos, Lange, Malin K., Mejer, Helena, Muñoz-Caro, Tamara, Penagos-Tabares, Felipe, Schaper, Roland, Taubert, Anja   +7 more
core   +4 more sources

Piplartine as an Innovative Natural Product With Dual Antiparasitic and Immunomodulatory Actions

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Neglected tropical diseases (NTDs) remain a major global health burden, disproportionately affecting low‐ and middle‐income regions and demanding innovative therapeutic strategies. This review summarizes current evidence on piplartine (piperlongumine), a naturally occurring amide from Piper species with broad antiparasitic and immunomodulatory ...
Lucas Fukui-Silva, Felipe C. R. de Souza, Camila S. Amorim, Josué de Moraes, Poorani Gurumallesh Prabu   +4 more
wiley   +1 more source

Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis. [PDF]

Nat Commun
In murine models of visceral leishmaniasis (VL), the parasitization of resident Kupffer cells (resKCs) drives early Leishmania infantum growth in the liver, leading to granuloma formation and subsequent parasite control.
Pessenda G, Ferreira TR, Paun A, Kabat J, Amaral EP, Kamenyeva O, Gazzinelli-Guimaraes PH, Perera SR, Ganesan S, Lee SH, Sacks DL.   +10 more
europepmc   +2 more sources

Atypical presentation of visceral leishmaniasis from non-endemic region [PDF]

, 2010
A case of atypical and acute presentation of visceral leishmaniasis from non-endemic region, characterised by exudative pleural effusion and hepatitis is ...
Gupta, D, Kashyap, R, Kaul, R, Raina, S
core   +1 more source

Profiling of human acquired immunity against the salivary proteins of Phlebotomus papatasi reveals clusters of differential immunoreactivity [PDF]

, 2014
Citation: Geraci, Nicholas S., Rami M. Mukbel, Michael T. Kemp, Mariha N. Wadsworth, Emil Lesho, Gwen M. Stayback, Matthew M. Champion, et al. 2014.
Abo-Shehada, Mahmoud, Bernard, Megan A., Champion, Matthew M., Coutinho-Abreu, Iliano V., El-Hossary, Shabaan S., Fawaz, Emadeldin Y., Geraci, Nicholas S., Hanafi, Hanafi A., Hoel, David F., Kemp, Michael T., Lesho, Emil, McDowell, Mary Ann, Mukbel, Rami M., Ramalho-Ortigão, Marcelo, Stayback, Gwen M., Wadsworth, Mariha N., Wortmann, Glenn   +16 more
core   +1 more source