Results 81 to 90 of about 10,698 (195)

In vitro initial immune response against Leishmania amazonensis infection is characterized by an increased production of IL-10 and IL-13

Brazilian Journal of Infectious Diseases
The initial encounter of Leishmania with its host's immune system is important in the outcome of infection. Previous studies have shown that PBMCs from healthy volunteers (HV) exposed to Leishmania differ in IFN-γ production.
Zirlane Castelo B Coêlho, Maria Jania Teixeira, Erika Freitas Mota, Mércia Sindeaux Frutuoso, João Santana da Silva, Aldina Barral, Manoel Barral-Netto, Margarida Maria L Pompeu   +7 more
doaj   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Characterization of the early inflammatory infiltrate at the feeding site of infected sand flies in mice protected from vector-transmitted Leishmania major by exposure to uninfected bites.

PLoS Neglected Tropical Diseases, 2014
BackgroundMice exposed to sand fly saliva are protected against vector-transmitted Leishmania major. Although protection has been related to IFN-γ producing T cells, the early inflammatory response orchestrating this outcome has not been defined ...
Clarissa Teixeira, Regis Gomes, Fabiano Oliveira, Claudio Meneses, Dana C Gilmore, Dia-Eldin A Elnaiem, Jesus G Valenzuela, Shaden Kamhawi   +7 more
doaj   +1 more source

Anisakis pegreffii impacts differentiation and function of human dendritic cells [PDF]

, 2018
Human dendritic cells (DCs) show remarkably phenotypic changes when matured in presence of helminth-derived products. These modifications frequently elicited a polarization towards Th2 cells and regulatory T cells thus contributing to immunological ...
Allen, Alonso-Gómez, Annunziato, Aranzamendi, Babal, Baeza, Battisti, Becher, Blanco, Coakley, Cortés, Cvetkovic, D'Amelio, Das Mohapatra, Daschner, Dowling, Entwistle, Gerbe, Giri, Gruden-Movsesijan, Hall, Hartmann, Hiemstra, Iborra, Ivanova, Johnson, Klaver, Kotsias, Kuijk, Lian, Lim, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Messina, Mladineo, Morris, Motran, Nakahara, Nieuwenhuizen, Pulendran, Rescigno, Rodríguez, Rughetti, Silva, Swofford, Terrazas, Ueno, Umehara, Witkowska, Zizzari   +55 more
core   +1 more source

Genome‐Wide Protein Interaction Analysis in Parasitic Gyrodactylus Flatworms–Fish Hosts System and Drug Target Identification

Advanced Science, Volume 12, Issue 45, December 4, 2025.
Genomic data offer a powerful tool for studying the molecular interactions between parasites and their hosts, but they remain scarce for parasitic monogenean flatworms. This study presents the first high‐quality phased genome assembly for monogeneans (Gyrodactylus kobayashii), and uses it to predict key interacting proteins between monogenean parasite ‐
Dong Zhang, Jie‐Mei Zhao, Chuan‐Yu Xiang, Yi‐Wen Ma, Hong‐Peng Lei, Yu‐Ying Shi, Shun Zhou, Xiaofei Zeng, Jinsong Chen, Fei Liu, Benhe Zeng, Rui Song, Ye Hu, Feng Zhang, Xiang Liu, Wen‐Xiang Li, Gui‐Tang Wang, Ivan Jakovlić   +17 more
wiley   +1 more source

Investigation of parasite genetic variation and systemic immune responses in patients presenting with different clinical presentations of cutaneous leishmaniasis caused by Leishmania aethiopica. [PDF]

Infect Dis Poverty
Background Cutaneous leishmaniasis (CL) is a neglected tropical skin disease, caused by the protozoan parasite Leishmania. In Ethiopia, CL is mainly caused by Leishmania aethiopica and can present in different clinical forms. The aim of this study was to
Yizengaw E, Takele Y, Franssen S, Gashaw B, Yimer M, Adem E, Nibret E, Yismaw G, Cruz Cervera E, Ejigu K, Tamiru D, Munshea A, Müller I, Weller R, Cotton JA, Kropf P.   +15 more
europepmc   +2 more sources

The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis. [PDF]

, 2014
Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic infections affecting millions of people across the subtropics.
Beverley, S.M., Drexler, S., Fasel, N., Hartley, M.A., Ronet, C.   +4 more
core   +1 more source

Disseminated Leishmaniasis, a Severe Form of Leishmania braziliensis Infection

Emerging Infectious Diseases
Disseminated leishmaniasis (DL) is an emergent severe disease manifesting with multiple lesions. To determine the relationship between immune response and clinical and therapeutic outcomes, we studied 101 DL and 101 cutaneous leishmaniasis (CL) cases and
Paulo R. L. Machado, A. Lago, T. Cardoso, A. Magalhães, Lucas P. Carvalho, Tainã Lago, A. Carvalho, Rubia S Costa, Edgard M. Carvalho   +8 more
semanticscholar   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Modular Nanosensing Platforms for Tuberculosis and Beyond: Engineering Biomaterials Toward Cross‐Pathogen Diagnostic Universality

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Modular nanosensing platforms utilize nanomaterials and functionalized interfaces to amplify trace different pathogens (like tuberculosis) antigen capture, suppress matrix interference, and enable multiplex detection. Their portability and cost‐effectiveness support rapid screening in resource‐limited settings and real‐time monitoring, advancing high ...
Mei Li, Yuxin Luo, Wenqiang Li, Yiqing Wang, Yunze Tai, Zhiping Deng, Yao Luo   +6 more
wiley   +1 more source