Results 51 to 60 of about 72,257 (309)

The bZIP Transcription Factor ZIP-11 Is Required for the Innate Immune Regulation in Caenorhabditis elegans

Frontiers in Immunology, 2021
Innate immunity is the first line of host defense against pathogen infection in metazoans. However, the molecular mechanisms of the complex immune regulatory network are not fully understood.
Zhongfan Zheng, Zhongfan Zheng, Yilixiati Aihemaiti, Yilixiati Aihemaiti, Junqiang Liu, Junqiang Liu, Muhammad Irfan Afridi, Muhammad Irfan Afridi, Shengmei Yang, Shengmei Yang, Xiumei Zhang, Xiumei Zhang, Yongfu Xu, Yongfu Xu, Chunhong Chen, Chunhong Chen, Haijun Tu, Haijun Tu   +17 more
doaj   +1 more source

Multivariate statistical analysis for the identification of potential seafood spoilage indicators [PDF]

, 2018
Volatile organic compounds (VOCs) characterize the spoilage of seafood packaged under modified atmospheres (MAs) and could thus be used for quality monitoring.
Abatih, Emmanuel, De Meulenaer, Bruno, Devlieghere, Frank, Ioannidis, Angelos-Gerasimos, Kuuliala, Lotta, Ragaert, Peter, Vanderroost, Mike   +6 more
core   +2 more sources

Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides

Advanced Science, EarlyView.
The authors introduce a high‐throughput synthesis using amide‐sulfoxonium ylides as new nucleophilic reagents, enabling a catalyst‐ and base‐free hydrocarbonation of terminal alkynes under mild conditions, resulting in various E‐alkene substituted (hetero)amide‐sulfoxonium ylides with excellent regio‐ and stereoselectivity. The late‐stage modifications
Haiting Wu, Yougen Xu, An Lin, Jingyuan Liu, Huanjun Chen, Shimin Xie, Lebin Su   +6 more
wiley   +1 more source

Evaluation of quality parameters of apple juices using near-infrared spectroscopy and chemometrics [PDF]

, 2018
Near-infrared (NIR) spectra were recorded for commercial apple juices. Analysis of these spectra using partial least squares (PLS) regression revealed quantitative relations between the spectra and quality- and taste-related properties of juices: soluble
Khmelinskii, Igor, Sikorska, Ewa, Wlodarska, Katarzyna   +2 more
core   +2 more sources

Plasmon Enhanced Universal SERS Detection of Hierarchical Plastics by 3D Plasmonic Funnel Metastructure

Advanced Science, EarlyView.
A 3D self‐assembled plasmonic nanostructure for ultrasensitive SERS detection of hierarchical micro‐nano plastic pollutants ranging from 30 nm to microns by rationally integrating high density of both surface and volumetric hot spots into one structure, enabled by V‐shaped close‐packed bi‐metallic nanoparticles with massive nanovoids across transverse ...
Weixi Lu, Jian Luo, Yuyang Zhuang, Jie Liang, Min Xiong, Hui Liu, Lin Zhou   +6 more
wiley   +1 more source

Emerging biomedical imaging-based companion diagnostics for precision medicine

iScience, 2023
Summary: The tumor heterogeneity, which leads to individual variations in tumor microenvironments, causes poor prognoses and limits therapeutic response.
Shiyi Liao, Mengjie Zhou, Youjuan Wang, Chang Lu, Baoli Yin, Ying Zhang, Huiyi Liu, Xia Yin, Guosheng Song   +8 more
doaj  

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Validation of Soft Classification Models using Partial Class Memberships: An Extended Concept of Sensitivity & Co. applied to the Grading of Astrocytoma Tissues [PDF]

Chemometrics and Intelligent Laboratory Systems, 122 (2013), 12 - 22, 2013
We use partial class memberships in soft classification to model uncertain labelling and mixtures of classes. Partial class memberships are not restricted to predictions, but may also occur in reference labels (ground truth, gold standard diagnosis) for training and validation data.
arxiv   +1 more source

General (hetero)polyaryl amine synthesis via multicomponent cycloaromatization of amines

Nature Communications
(Hetero)polyaryl amines are extensively prevalent in pharmaceuticals, fine chemicals, and materials but the intricate and varied nature of their structures severely restricts their synthesis. Here, we present a selective multicomponent cycloaromatization
Lebin Su, Jianyu Dong, Yang Shen, Shimin Xie, Shaofeng Wu, Neng Pan, Feng Liu, Qian Shang, Fangfang Cai, Tian-Bing Ren, Lin Yuan, Shuang-Feng Yin, Li-Biao Han, Yongbo Zhou   +13 more
doaj   +1 more source

ADME-Space: a new tool for medicinal chemists to explore ADME properties

Scientific Reports, 2017
We introduce a new chemical space for drugs and drug-like molecules, exclusively based on their in silico ADME behaviour. This ADME-Space is based on self-organizing map (SOM) applied to 26,000 molecules. Twenty accurate QSPR models, describing important
Giovanni Bocci, Emanuele Carosati, Philippe Vayer, Alban Arrault, Sylvain Lozano, Gabriele Cruciani   +5 more
doaj   +1 more source