Results 101 to 110 of about 168,140 (338)

Salvage esophagectomy for unresectable locally advanced esophageal squamous cell carcinoma: Significant or not?

Annals of Gastroenterological Surgery, EarlyView.
Abstract We reviewed the current status and perspectives on salvage esophagectomy for initially unresectable locally advanced esophageal squamous cell carcinoma (ESCC) in the era of minimally invasive surgery and immunotherapy. Although the standard treatment for these patients is definitive chemoradiotherapy (CRT), the complete response rate to CRT ...
Hiroshi Saeki, Makoto Sakai, Takayoshi Watanabe, Makoto Sohda, Ken Shirabe   +4 more
wiley   +1 more source

The heart’s exposure to radiation increases the risk of cardiac toxicity after chemoradiotherapy for superficial esophageal cancer: a retrospective cohort study

BMC Cancer, 2019
Background Chemoradiotherapy effectively treats superficial esophageal cancer and is optimal to preserve organs. However, late toxicity, particularly in cardiac diseases, obstructs clinical outcomes.
Yoshito Hayashi, Hideki Iijima, Fumiaki Isohashi, Yoshiki Tsujii, Tetsuji Fujinaga, Kengo Nagai, Shunsuke Yoshii, Akihiko Sakatani, Satoshi Hiyama, Shinichiro Shinzaki, Tomoki Makino, Makoto Yamasaki, Kazuhiko Ogawa, Yuichiro Doki, Tetsuo Takehara   +14 more
doaj   +1 more source

Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction.

New England Journal of Medicine, 2001
BACKGROUND Surgical resection of adenocarcinoma of the stomach is curative in less than 40 percent of cases. We investigated the effect of surgery plus postoperative (adjuvant) chemoradiotherapy on the survival of patients with resectable adenocarcinoma ...
J. Macdonald, S. Smalley, J. Benedetti, S. Hundahl, N. Estes, G. Stemmermann, D. Haller, J. Ajani, L. Gunderson, J. Jessup, J. Martenson   +10 more
semanticscholar   +1 more source

Effect of Intraoperative Posture on Accurate Diagnostic Rate of Intraoperative Nerve Monitoring During Esophagectomy

Annals of Gastroenterological Surgery, EarlyView.
Adequate contact between the intubation tube and the vocal cord muscles is crucial for effective intraoperative nerve monitoring use during esophagectomy. Additionally, intraoperative posture significantly affects diagnostic outcomes and should be carefully considered.
Masami Yuda, Keita Takahashi, Yoshitaka Ishikawa, Takanori Kurogochi, Akira Matsumoto, Naoko Fukushima, Takahiro Masuda, Naoto Takahashi, Fumiaki Yano, Ken Eto   +9 more
wiley   +1 more source

Safety and Efficacy of Pembrolizumab With Chemoradiotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase IB Study.

Journal of Clinical Oncology, 2020
PURPOSE Pembrolizumab is a humanized monoclonal antibody that blocks interaction between programmed death receptor-1 (PD-1) and its ligands (PD-L1, PD-L2). Although pembrolizumab is approved for recurrent/metastatic head and neck squamous cell carcinoma (
S. Powell, K. Gold, M. Gitau, C. Sumey, Michele M. Lohr, Steven C. McGraw, R. K. Nowak, A. Jensen, M. Blanchard, Christopher D Fischer, J. Bykowski, C. Ellison, L. Black, P. Thompson, J. Callejas-Valera, John H. Lee, E. Cohen, W. Spanos   +17 more
semanticscholar   +1 more source

Preoperative chemoradiation versus radiation alone for stage II and III resectable rectal cancer [PDF]

, 2013
Background : Preoperative radiotherapy (RT) decreases local recurrence rate and improves survival in stage II and III rectal cancer patients. The combination of chemotherapy with RT has a sound radiobiological rationale, and phase II trials of combined ...
Ceelen, Wim, DE CALUWE, LAURA, Van Nieuwenhove, Yves   +2 more
core   +1 more source

Prognostic Impact of Bone Mineral Density Reduction During Neoadjuvant Chemotherapy (NAC) in Patients Undergoing NAC Followed by Esophagectomy for Esophageal Cancer

Annals of Gastroenterological Surgery, EarlyView.
The association between BMD reduction during NAC and the worse prognosis remains unknown, although NAC followed by esophagectomy is a standard treatment for advanced ESCC. This study appeared that BMD massive reduction was an independent prognostic factor on OS (HR, 3.30; 95% confidence interval [CI], 1.69–6.55) and RFS (HR, 2.08; 95% CI, 1.19–3.63 ...
Kazuhide Sato, Keita Takahashi, Yoshitaka Ishikawa, Naoko Fukushima, Takahiro Masuda, Takanori Kurogochi, Masami Yuda, Akira Matsumoto, Kazuto Tsuboi, Yuichiro Tanishima, Fumiaki Yano, Ken Eto   +11 more
wiley   +1 more source

Circulating tumor DNA analysis for detection of minimal residual disease after chemoradiotherapy for localized esophageal cancer.

Gastroenterology, 2019
BACKGROUND & AIMS Biomarkers are needed to identify patients at risk of tumor progression following chemoradiotherapy for localized esophageal cancer. These could improve identification of patients at risk for cancer progression and selection of therapy.
T. Azad, A. Chaudhuri, P. Fang, Y. Qiao, M. S. Esfahani, J. Chabon, Emily G. Hamilton, Yi D Yang, A. Lovejoy, Aaron M. Newman, D. Kurtz, M. Jin, J. Schroers-Martin, H. Stehr, C. Liu, A. Bik‐Yu Hui, V. Patel, D. Maru, Steven H. Lin, Ash A. Alizadeh, M. Diehn   +20 more
semanticscholar   +1 more source

Mandatory multidisciplinary approach for the evaluation of the lymph node status in rectal cancer [PDF]

, 2018
Colorectal cancer is the third most frequently reported malignancy and also the third leading cancer-related cause of death worldwide. Lymph node evaluation, both preoperatively and postoperatively, represents an important aspect of the diagnosis and ...
Ciorbagiu, Mihai C., Diaconescu, Marian, Mirea, Cecil S., Moraru, Emil, Obleaga, Cosmin V., Vilcea, Ionica D.   +5 more
core   +4 more sources

Survival Outcomes of Esophageal Squamous Cell Carcinoma Patients Who Underwent Salvage Esophagectomy: A Literature Review and Results From Two High‐Volume Centers

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to investigate survival outcomes, the efficacy of lymph node (LN) dissection, and recurrence patterns in 69 patients who underwent R0 salvage surgery for esophageal squamous cell carcinoma. Of note, abdominal LN metastases had a negative impact on survival in our series.
Kotaro Sugawara, Koichi Yagi, Takashi Fukuda, Shoh Yajima, Daiji Oka, Yoshiyuki Miwa, Shuichiro Oya, Asami Okamoto, Raito Asaoka, Yoshifumi Baba   +9 more
wiley   +1 more source