Results 21 to 30 of about 93,945 (299)

A novel sphingolipid metabolism-related long noncoding RNA signature predicts the prognosis, immune landscape and therapeutic response in pancreatic adenocarcinoma

Heliyon
Sphingolipid metabolism affects prognosis and resistance to immunotherapy in patients with cancer and is an emerging target in cancer therapy with promising diagnostic and prognostic value.
Xiaolan He, Zhengyang Xu, Ruiping Ren, Peng Wan, Yu Zhang, Liangliang Wang, Ying Han   +6 more
doaj   +1 more source

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer? [PDF]

Ann Gastroenterol Surg
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Yamashita K, Matsuda T, Mukohyama J, Sasaki R, Kakeji Y.   +4 more
europepmc   +2 more sources

Improving chemoradiotherapy with nanoparticle therapeutics [PDF]

, 2013
Chemoradiotherapy has been a key treatment paradigm in cancer management. One of the main research objectives in cancer research has been to identify agents and strategies to improve the therapeutic index of chemoradiation.
Wang, Andrew Zhuang, Eblan, Michael Joseph   +1 more
core   +1 more source

Proline-rich protein 11 overexpression is associated with a more aggressive phenotype and poor overall survival in ovarian cancer patients

World Journal of Surgical Oncology, 2020
Background The proline-rich protein 11 (PRR11) is a newly identified oncogene associated with a poor prognosis in several human cancers. Nonetheless, research on its role in ovarian cancer (OC) remains largely understudied.
Yu Zhan, Xueyuan Wu, Gang Zheng, Jingjing Jin, Chaofu Li, Guanzhen Yu, Wenfeng Li   +6 more
doaj   +1 more source

Efficacy of Chemotherapy in Survival of Stage I Nasopharyngeal Carcinoma

Frontiers in Oncology, 2021
PurposeTo identify whether chemoradiotherapy improves survival of stage I nasopharyngeal carcinoma (NPC).Materials and MethodsNPC patients were extracted from the Surveillance, Epidemiology, and End Results database between 2010 and 2015.
Jia-Lin Ma, Shi-Ting Huang, Yan-Ming Jiang, Xin-Bin Pan   +3 more
doaj   +1 more source

Impact of maintenance of postoperative performance status on survival in elderly patients over 70 with high-grade astrocytoma [PDF]

, 2020
2020-08This study aimed to identify the elderly generation with the worst prognoses for high-grade astrocytoma and find independent predictors of good outcomes.
Deguchi, Shoichi, Oishi, Takuma, Nakasu, Yoko, Mitsuya, Koichi, Sugino, Takashi, Hayashi, Nakamasa   +5 more
core   +1 more source

Nimotuzumab combined with chemoradiotherapy for the treatment of cervical cancer: A meta-analysis of randomized controlled trials

Frontiers in Oncology, 2022
ObjectivesTo assess the clinical efficacy and toxicity of nimotuzumab in combination with chemoradiotherapy or chemoradiotherapy alone in the treatment of cervical cancer.MethodsThe PubMed, Embase, Cochrane Library, Web of Science, China National ...
Yan Yuan, Yan Yuan, Jiuzhou Chen, Jiuzhou Chen, Miao Fang, Miao Fang, Yaru Guo, Yaru Guo, Xueqing Sun, Xueqing Sun, Dehong Yu, Yilong Guo, Yong Xin, Yong Xin   +13 more
doaj   +1 more source

Construction of a novel CD8T cell-related index for predicting clinical outcomes and immune landscape in ovarian cancer by combined single-cell and RNA-sequencing analysis

Discover Oncology
Background CD8T cells, also known as cytotoxic T lymphocytes, play a key role in the tumor immune microenvironment (TME) and immune response. The aim of this study was to explore the potential role of CD8T cell-associated biomarkers in predicting ...
Yu Zhang, Peng Wan, Liangliang Wang, Ruiping Ren   +3 more
doaj   +1 more source

DataSheet_1_Neoadjuvant chemoradiotherapy for resectable gastric cancer: A meta-analysis.docx

, 2022
ObjectivesTo evaluate the clinical curative effects and toxicity of neoadjuvant chemoradiotherapy for resectable gastric cancer compared to those of neoadjuvant chemotherapy.MethodsA systematic review and meta-analysis of the randomized controlled trials
Yan Yuan (20767), Miao Fang (846169), Yong Xin (11354142), Youqi Zhu (1678549), Yaru Guo (6371594), Jiuzhou Chen (8559384), Longzhen Zhang (730389)   +6 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source