Results 31 to 40 of about 97,795 (300)

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

The Role of NF-κB/MIR155HG in Regulating the Stemness and Radioresistance in Breast Cancer Stem Cells

Frontiers in Bioscience-Landmark
Background: Breast cancer stem cells (BCSCs) are instrumental in treatment resistance, recurrence, and metastasis. The development of breast cancer and radiation sensitivity is intimately pertinent to long non-coding RNA (lncRNA). This
Yunbao Xu, Lu Yang, Guangming Li, Chuangzhou Rao   +3 more
doaj   +1 more source

Preoperative versus postoperative chemoradiotherapy for rectal cancer

, 2004
BACKGROUND: Postoperative chemoradiotherapy is the recommended standard therapy for patients with locally advanced rectal cancer. In recent years, encouraging results with preoperative radiotherapy have been reported.
Becker, H., Wittekind, Christian, Hager, Eva, Sauer, R., Fietkau, Rainer, Karstens, Johann, Schmidberger, Heinz, Martus, Peter, Hess, C. F., Liersch, Thorsten, Rodel, C., Hohenberger, Werner, Tschmelitsch, Joerg, Raab, Hans-Rudolf   +13 more
core   +1 more source

Inhibition of GABAA receptors in intestinal stem cells prevents chemoradiotherapy-induced intestinal toxicity. [PDF]

, 2022
peer reviewedLethal intestinal tissue toxicity is a common side effect and a dose-limiting factor in chemoradiotherapy. Chemoradiotherapy can trigger DNA damage and induce P53-dependent apoptosis in LGR5+ intestinal stem cells (ISCs).
Yu, Xin, Mu, Kun, Ning, Nannan, Zhou, Yuping, Li, Jingxin, Jiang, Wenyang, Zheng, Junjie, Guo, Wei, Zhang, Cuiyu, Li, Yan, Chen, Dawei, Hu, Huili, Liu, Haining   +12 more
core   +2 more sources

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Treatment outcomes according to concurrent chemoradiotherapy duration.

, 2019
Treatment outcomes according to concurrent chemoradiotherapy duration.
Ugur Selek (7022486), Yurday Ozdemir (7022477), Huseyin Mertsoylu (7022483), Ali Ayberk Besen (7022480), Ahmet Sezer (5965040), Ahmet Kucuk (3371915), Erkan Topkan (7022474)   +6 more
core   +1 more source

Impact of chemoradiotherapy for first primary lung cancer on the prognosis and re-chemoradiotherapy sensitivity of second primary lung cancer [PDF]

BackgroundDespite undergoing surgery and chemoradiotherapy, patients with first primary lung cancer (FPLC) remain at risk for second primary lung cancer (SPLC), which is associated with a poor prognosis.
Jiangjiang Liu, Nan Wang, Gaoming Wang, Kai Xie, Zhe Chen, Haitao Ma, Jing Luo, Yu Yao   +7 more
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Preoperative chemoradiotherapy for esophageal or junctional cancer.

, 2012
BACKGROUND: The role of neoadjuvant chemoradiotherapy in the treatment of patients with esophageal or esophagogastric-junction cancer is not well established. We compared chemoradiotherapy followed by surgery with surgery alone in this patient population.
van Lanschot, J. J. B., Piet, A. H. M., Dekken, H. (Herman) van, Punt, C.J.A., Spaander, Manon, Hospers, G.A.P. (Geke), Beukema, JC, Steyerberg, E.W., van Lanschot, Jan, Reinders, J.G., Hospers, G. A. P., Hagen, P. (Pieter) van, van der Gaast, A., Wijnhoven, B.P.L. (Bas), Tilanus, H. W., Berge Henegouwen, M.I. (Mark) van, van Dekken, H (Herman), Cuesta, M.A. (Miguel), Henegouwen, MIV, Richel, D.J., Gaast, A. van der, Biermann, Katharina, Dekken, H. van, Verheul, HMW, ten Kate, F. J. W., van Rij, Caroline, Tilanus, H.W. (Hugo), Hulshof, MCCM, Wijnhoven, B. P. L., Plukker, J. T. M., Punt, CJA, Spillenaar Bilgen, E.J. (Ernst Jan), Biermann, K., Bonenkamp, J.J. (Han), Nieuwenhuijzen, G. A. P., Steyerberg, E. W., Bonenkamp, J.J., Rozema, T., Henegouwen, M. I. van Berge, Tilanus, H.W., van der Gaast, Ate, van Hagen, P., Bilgen, EJS, Busch, ORC, Punt, C.J.A. (Cornelis), van Dekken, H., Lanschot, J.J.B. (Jan) van, Busch, O. R. C., Plukker, JTM, Richel, DJ, Piet, AHM, Reinders, J.G.P. (Jurrien), Reinders, JG, Kate, Fiebo, Busch, O.R.C. (Olivier), Cuesta, MA, Bilgen, E. J. Spillenaar, Nieuwenhuijzen, GAP, Beukema, J. C., Rozema, T. (Tom), Verheul, H.M.W. (Henk), Verheul, H. M. W., Creemers, G.J.M. (Geert-Jan), Gaast, A. (Ate) van der, Tilanus, Hugo, Hulshof, M.C.C.M. (Maarten), Bonenkamp, J. J., Steyerberg, E.W. (Ewout), Punt, C. J. A., Richel, D. J., Beukema, J.C. (Jannet), Sangen, M.J.C. (Maurice) van der, Bonenkamp, JJ, Kate, F.J.W. (Fiebo) ten, Wijnhoven, Bas, Creemers, G.J., Hagen, Pieter, Hospers, GAP, Blaisse, R. J. B., Rozema, T, Steyerberg, Ewout, Hagen, P. van, Rij, C.M. (Caroline) van, Cuesta, M. A., Hulshof, M.C.C.M., Plukker, J.T. (John), Cuesta, M.A., Blaisse, RJB, Piet, A.H.M. (A. H M), Richel, D.J. (Dirk), van Rij, C. M., Beukema, J. C.; id_orcid, Blaisse, R.J.B., van der Sangen, M. J. C., Creemers, GJ, Creemers, G. -J., Beukema, J.C., Reinders, J. G., Biermann, K. (Katharina), van der Sangen, MJC, Nieuwenhuijzen, G.A.P. (Gerard), Berge Henegouwen, M.I. van, Blaisse, R.J., Nieuwenhuijzen, G.A., Hulshof, M.C.C., Hospers, G.A., Busch, O.R., Rij, C.M. van, Wijnhoven, B.P., Sangen, M.J. van der, Piet, A.H., Kate, F.J. ten, Verheul, H.M., Krieken, J.H. van, et al., Spillenaar Bilgen, E.J., Plukker, J.T., Lanschot, J.J. van   +117 more
core   +2 more sources