Results 51 to 60 of about 97,795 (300)

Kaplan-Meier estimates of relapse-free survival and disease-free survival for patients receiving Neoadjuvant-concurrent chemoradiotherapy versus Concurrent chemoradiotherapy versus IMRT alone.

, 2013
Kaplan-Meier estimates of relapse-free survival and disease-free survival for patients receiving Neoadjuvant-concurrent chemoradiotherapy versus Concurrent chemoradiotherapy versus IMRT alone.
Yajuan Zhou (282972), Xia Fan (282967), Xuemei Ji (282962), Desheng Hu (282965), Conghua Xie (282964), Yingjie Zheng (282977)   +5 more
core   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

Neoadjuvant chemoradiotherapy for esophageal carcinoma

, 2005
Neoadjuvant chemoradiotherapy is often administered to patients with esophageal carcinoma in the belief that this will improve survival. However, its role in the management of esophageal carcinoma remains controversial.
Bessell, J., Watson, D., Devitt, P., J. R. Bessell, X. Zhang, Watson, David Ian, Zhang, X., Jamieson, Glyn G, Zhang, X, Devitt, Peter G, Jamieson, G., D. I. Watson, P. G. Devitt, G. G. Jamieson, Bessell, Justin   +14 more
core   +1 more source

Harnessing Methylselenol (CH3SeH): A Highly Effective Platform for Stimuli‐Responsive Delivery With Therapeutic Potential

Advanced Science, EarlyView.
Tools for controlled selenol delivery are crucial for exploring Se‐related biology and medicine, but compound platforms for triggerable release of CH3SeH remain lacking. Herein, we report the first general triggered platform (TD‐MSe) for efficient cyclization release of CH3SeH in live cells.
Wenfang Liang, Liyue Wang, Xuan Wang, Xinran Li, Hao Xing, Lu Sun, Zhen Xi, Long Yi   +7 more
wiley   +1 more source

Beyond dual targeting: redefining the treatment horizon for true extramedullary myeloma? – a critical appraisal

Frontiers in Oncology
The management of relapsed/refractory multiple myeloma with true extramedullary disease (EMD) remains a critical challenge. The phase 2 RedirecTT-1 study evaluated the combination of two bispecific antibodies, talquetamab (anti-GPRC5D) and teclistamab ...
Qinghua Ke, Shiqiong Zhou
doaj   +1 more source

Adverse effects of chemoradiotherapy on invasion and metastasis of tumor cells

Genes and Diseases, 2020
The phenomenon of enhanced invasion and metastasis of residual tumor cells has been observed in an increasing number of patients receiving chemoradiotherapy recently, and tumor metastasis will undoubtedly limit patient prognosis.
Wei Xiong, Yong Liao, Ji-Yong Qin, Wen-Hui Li, Zhao-You Tang   +4 more
doaj   +1 more source

Characteristics of clinical trials of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy.

, 2018
Characteristics of clinical trials of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy.
Yiming Ren (4708444), Naiqiang Cui (5679890), Xin Zhao (71840), Yunfeng Cui (698674), Yong Hu (171926), Ximo Wang (324678)   +5 more
core   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

The efficacy of concurrent chemoradiotherapy with or without nimotuzumab in high-risk patients with locally advanced head and neck squamous cell carcinoma post-surgery: A real-world study. [PDF]

Precis Radiat Oncol
Figure 1 Patient selection flowchart. CCRT, concurrent chemoradiotherapy; NCCRT, nimotuzumab and concurrent chemoradiotherapy. Abstract Purpose Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) harboring high‐risk pathological features after radical surgery face high recurrence rates.
Zhou Y, Zhang L, Lai W, Tan J, Gao J, Liu Y, Wang S, Peng F, Tong G.   +8 more
europepmc   +2 more sources