Results 41 to 50 of about 97,795 (300)

Dual-targeting bispecific antibodies against extramedullary myeloma: A hypothesis-driven commentary

Translational Oncology
Extramedullary multiple myeloma (EMD) remains a high-risk clinical entity with limited responsiveness to currently available therapies, including single-agent T-cell-redirecting approaches.
Shiqiong Zhou, Qinghua Ke
doaj   +1 more source

m5C Reader ALYREF Promotes the Progression of Endometrial Cancer by Activating the XRCC6‐Mediated Wnt/β‐catenin Signaling Pathway

Advanced Science, EarlyView.
This study identifies ALYREF as an oncogenic m5C reader in endometrial cancer. ALYREF recognizes NSUN2‐mediated m5C modification on XRCC6 mRNA to enhance transcript stability and increase XRCC6 expression. Elevated XRCC6 activates Wnt/β‐catenin signaling, resulting in accelerated tumor cell proliferation, migration, invasion, and xenograft tumor growth.
Linlin Hao, Jian Zhang, Qi Qian, Min Jiang, Yu Liu, Yan Geng, Nan Cui, Qi Guo, Jie Guo   +8 more
wiley   +1 more source

Exploring the Role of Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease

Pharmaceuticals
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder among the elderly population. The pathogenesis of PD encompasses genetic alterations, environmental factors, and age-related neurodegenerative processes.
Yiting Zhao, Man Lin, Fengguang Zhai, Jun Chen, Xiaofeng Jin   +4 more
doaj   +1 more source

Self‐Cooperative Prodrug Nanovesicles Migrate Immune Evasion to Potentiate Chemoradiotherapy in Head and Neck Cancer

, 2022
Chemoradiotherapy is the standard of care for the clinical treatment of locally advanced head and neck cancers. However, the combination of ion radiation with free chemotherapeutics yields unsatisfactory therapeutic output and severe side effects due to ...
Tingting Wang, Yi Lai, Yun Zhu, Fangmin Chen, Fengyang Wang, Jiaxing Pan, Haijun Yu, Shunan Zhang, Zhiai Xu, Wenjun Yang   +9 more
core   +1 more source

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source

B cells in nasopharyngeal carcinoma: From prognostic signal to therapeutic hypothesis—A critical appraisal of the RATIONALE-309 biomarker analysis

Translational Oncology
The 3-year follow-up of the phase 3 RATIONALE-309 trial confirmed sustained progression-free and overall survival (OS) benefit with tislelizumab plus gemcitabine-cisplatin in recurrent/metastatic nasopharyngeal carcinoma (R/M NPC).
Qing-Hua Ke, Shi-Qiong Zhou
doaj   +1 more source

Outcome of neoadjuvant chemotherapy followed by concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in non-metastatic locally advanced non-small cell lung cancer – A prospective and randomized study

Asian Journal of Medical Sciences, 2023
Background: Sequential chemoradiotherapy and concurrent chemoradiotherapy are two treatment options for locally advanced non-small cell lung cancer (NSCLC). Still there is limited data regarding which is the better treatment option.
Subir Pal , Anjan Bera , Soumen Mukherjee , Asmita Dasgupta , Srikrishna Mandal , Saptarshi Banerjee   +5 more
doaj   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

SOX2 promotes radiotherapy resistance in lung cancer via HSP70-mediated autophagy

European Journal of Medical Research
Lung cancer is a highly prevalent malignant tumor, and radiotherapy serves as one of its primary treatment modalities. However, radiotherapy resistance significantly limits therapeutic efficacy.
Jingtao Tong, Yajie Shi, Guodong Xu, Yanggang Dan, Bingchuan Hu, Hui Zhang, Quan Xu, Kaitai Liu   +7 more
doaj   +1 more source