Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders. [PDF]
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Bacterial sensor evolved by decreasing complexity. [PDF]
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Characterisation of putative retrotrapezoid nucleus (RTN) chemoreceptor neurons in the adult human brainstem. [PDF]
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Managing dangerous liaisons: lessons from <i>Helicobacter pylori</i> for understanding bacterial carcinogenesis. [PDF]
Snow JA, Hatzios SK, Salama NR.
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Acute oxygen sensing-Role of metabolic specifications in peripheral chemoreceptor cells.
Respiratory Physiology & Neurobiology, 2019Acute oxygen sensing is essential for humans under hypoxic environments or pathologic conditions. This is achieved by the carotid body (CB), the key arterial chemoreceptor, along with other peripheral chemoreceptor organs, such as the adrenal medulla (AM)
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Immunocytochemical localization of O2‐sensing protein (NADPH oxidase) in chemoreceptor cells
Microscopy Research and Technique, 1997A potential candidate for an oxygen-sensing protein in chemoreceptor cells is a heme-linked multicomponent NADPH oxidase, originally described in neutrophils. The postulated function for the oxidase in chemoreceptor cells is to signal changes in oxygen levels (either in the blood or in the airway lumen) via changes in oxygen metabolite production.
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Characterization of cultured chemoreceptor cells dissociated from adult rabbit carotid body.
American Journal of Physiology-Cell Physiology, 1992Short-term cell cultures were obtained from enzymatically dissociated carotid bodies from adult rabbits, and morphological and functional characterization of the cultured chemoreceptor cells were carried out. Under phase contrast, freshly isolated type I cells are round, bright, and 10-14 microns in diameter and exhibit strong fluorescence when ...
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Acetylcholine increases intracellular calcium of arterial chemoreceptor cells of adult cats.
Journal of Neurophysiology, 1997Shirahata, Machiko, Robert S. Fitzgerald, and James S. K. Sham. Acetylcholine increases intracellular calcium of arterial chemoreceptor cells of adult cats. J. Neurophysiol. 78: 2388–2395, 1997. Several neurotransmitters have been reported to play important roles in the chemoreception of the carotid body.
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Electron Microscopy of the Chemoreceptor Cells of the Carotid Labyrinth of the Toad
Nature, 1966K. Ishii, T. Oosaki
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