Results 171 to 180 of about 139,216 (290)

Cell elongation is key to in silico replication of in vitro vasculogenesis and subsequent remodeling [PDF]

open access: yes, 2006
BRODSKY, SV   +4 more
core  

Expression of Glycoprotein B (gB) Correlates With Poor Prognosis in Nasopharyngeal Carcinoma

open access: yesCancer Science, EarlyView.
The extent of EBV lytic replication in NPC has not been fully clarified. Our study demonstrated EBV replication and release in NPC and identified a significant association between expression of the late lytic protein gB and poor prognosis. These findings suggest that late lytic gene products may contribute to tumor progression and that gB represents a ...
Shigetaka Komura   +24 more
wiley   +1 more source

Autophagy Inhibition by Fangji Huangqi Decoction Enhances Tumor Immunogenicity and Potentiates PD‐1 Blockade

open access: yesCancer Science, EarlyView.
In tumor cells, MHC‐I is typically degraded through autophagy, leading to reduced antigen presentation. However, Fangji Huangqi Decoction (FJHQ), acting as an autophagy inhibitor, suppresses lysosomal acidification, which in turn inhibits the degradation of MHC‐I. This results in increased surface expression of MHC‐I on tumor cells.
Yuxiao Jiang   +18 more
wiley   +1 more source

Monocyte Chemotactic Factors in the Airways of Patients With Mild Asthma Before and After an Allergen Challenge

open access: yes
Allergy, EarlyView.
Nami Shrestha Palikhe   +7 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

open access: yesThe FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

open access: yesThe FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki   +4 more
wiley   +1 more source

Beyond the chaos: How architecture structures tumour biology

open access: yesThe FEBS Journal, EarlyView.
Tissue architecture shapes tumour initiation and progression through multiple interconnected layers continuously remodelled over time. This review outlines how physical forces, biochemical cues, cellular niches and systemic influences contribute to tumour evolution.
Lea Dörner   +3 more
wiley   +1 more source

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