Results 81 to 90 of about 98,425 (307)

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

Advanced Science
To move forward, cells must exert backward forces against their surrounding environment. Recent studies have highlighted the importance of integrin‐independent forces for cell migration; however, the molecular machinery that exerts forces remains unclear.
Kentarou Baba, Ami Fukushi‐Kumagai, Megumi Morisaki, Ryosuke Takeuchi, Zhize Xiao, Yoshikazu Nagashima, Mizuki Sakai, Yasuna Higashiguchi, Hiroko Katsuno‐Kambe, Asako Katsuma, Yoshihiro Ueda, Yuji Kamioka, Daisuke Kawauchi, Tatsuo Kinashi, Yonehiro Kanemura, Naoyuki Inagaki   +15 more
doaj   +1 more source

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Serum Amyloid A1 (SAA1) Revisited: Restricted Leukocyte-Activating Properties of Homogeneous SAA1

Frontiers in Immunology, 2020
Infection, sterile injury, and chronic inflammation trigger the acute phase response in order to re-establish homeostasis. This response includes production of positive acute phase proteins in the liver, such as members of the serum amyloid A (SAA ...
Sara Abouelasrar Salama, Mirre De Bondt, Mieke De Buck, Nele Berghmans, Paul Proost, Vivian Louise Soares Oliveira, Vivian Louise Soares Oliveira, Flavio A. Amaral, Mieke Gouwy, Jo Van Damme, Sofie Struyf   +10 more
doaj   +1 more source

RNA interference in J774 macrophages reveals a role for coronin 1 in mycobacterial trafficking but not in actin-dependent processes [PDF]

, 2008
Macrophages are crucial for innate immunity, apoptosis, and tissue remodeling, processes that rely on the capacity of macrophages to internalize and process cargo through phagocytosis.
Rajesh Jayachandran, John Gatfield, Jan Massner, Imke Albrecht, Bettina Zanolari, Jean Pieters, Sandra Schmid, Aderem A., Allen L. A., Araki N., Brummelkamp T. R., David V., de Hostos E. L., de Hostos E. L., de Hostos E. L., Ferrari G., Ferrari G., Foger N., Gatfield J., Gerisch G., Goode B. L., Grogan A., Guerin I., Heil-Chapdelaine R. A., Humphries C. L., Itoh S., Jayachandran R., Johannes L., Maniak M., Nal B., Nguyen L., Okumura M., Pantaloni D., Parente J. A., Pieters J., Rybakin V., Scherr N., Schuller S., Smith T. F., Steinman R. M., Suzuki K., Tailleux L., Tulp A., Vieira O. V., Walburger A., Zheng P. Y.   +45 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

The Three R\u27s of Delayed Hypersensitivity [PDF]

, 1974
Delayed hypersensitivity is one of several immune responses initiated by thymus-derived (T) lymphocytes. The mononuclear infiltrate of delayed hypersensitivity is a collaborative phenomenon between T lymphocytes and monocytes.
Horwitz, David
core   +1 more source

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]

, 2011
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
A Cvejic, A Millius, A Mogilner, A Narang, A. P Wheeler, B Varnum-Finney, C Arrieumerlou, C Janetopoulos, C. I Lacayo, C. P McCann, Douwe M. Veltman, G Dziuk, G Gerisch, H Levine, H Meinhardt, H. R Bourne, I. M Mitchell, J Satulovsky, J. A Swanson, John A. Mackenzie, K Keren, K. F Swaney, L Bosgraaf, L Bosgraaf, L Chen, L Li, L Ma, M Enculescu, M. A Lokuta, M. P Neilson, Matthew P. Neilson, N Andrew, O Brandman, O Hoeller, O. D Weiner, O. D Weiner, P Devreotes, P. A Iglesias, P. J Van Haastert, Peter J. M. van Haastert, R. H Insall, R. H Insall, R. H Insall, R. T Tranquillo, Robert H. Insall, S Osher, S Srinivasan, Steven D. Webb, T Inoue, T Killich, T Killich, Thomas Pollard, X Zheng   +52 more
core   +8 more sources

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]

, 2019
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core   +1 more source