Results 51 to 60 of about 212,420 (268)

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

Molecular Oncology, EarlyView.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang, Simone van de Weerd, Veerle Lammers, Sander van Hooff, Inge van den Berg, Saskia van den Bergh, Miriam Koopman, Jan N. IJzermans, Jeanine M. L. Roodhart, Jan Koster, Jan Paul Medema   +10 more
wiley   +1 more source

Tumor budding may be a promising prognostic indicator in intrahepatic cholangiocarcinoma: A multicenter retrospective study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 138-146, January 2023., 2023
High tumor budding is a new candidate for an additional determinant of the T category in staging ICC. An LCSGJ staging system containing an additional evaluation of tumor budding may lead to improved staging accuracy. Abstract Purpose This retrospective study evaluated our hypothesis that high tumor budding (≥10 buds) may help determine the appropriate
Hisashi Kosaka, Mitsuaki Ishida, Masaki Ueno, Koji Komeda, Daisuke Hokutou, Hiroya Iida, Fumitoshi Hirokawa, Kosuke Matsui, Mitsugu Sekimoto, Masaki Kaibori   +9 more
wiley   +1 more source

Predictive value of a reduction in the level of high-density lipoprotein-cholesterol in patients with non-small-cell lung cancer undergoing radical resection and adjuvant chemotherapy: a retrospective observational study

Lipids in Health and Disease, 2021
Background Cancer patients often exhibit chemotherapy-associated changes in serum lipid profiles, however, their prognostic value before and after adjuvant chemotherapy on survival among non-small-cell lung cancer (NSCLC) patients is unknown.
Fan Luo, Kang-mei Zeng, Jia-xin Cao, Ting Zhou, Su-xia Lin, Wen-juan Ma, Yun-peng Yang, Zhong-han Zhang, Fei-teng Lu, Yan Huang, Hong-yun Zhao, Li Zhang   +11 more
doaj   +1 more source

Doubly robust estimators for generalizing treatment effects on survival outcomes from randomized controlled trials to a target population [PDF]

arXiv, 2022
In the presence of heterogeneity between the randomized controlled trial (RCT) participants and the target population, evaluating the treatment effect solely based on the RCT often leads to biased quantification of the real-world treatment effect. To address the problem of lack of generalizability for the treatment effect estimated by the RCT sample ...
arxiv  

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Survival outcomes of laparoscopic versus open total gastrectomy with nodal dissection for gastric cancer in a high‐volume Japanese center: A propensity score‐matched analysis

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 53-62, January 2023., 2023
To compare the survival outcomes of laparoscopic total gastrectomy (LTG) with those of open total gastrectomy (OTG), 580 patients were enrolled and 1:1 propensity score matching was implemented to reduce selection bias. Five‐year overall survival was better in the LTG group, and there was no significant difference in overall survival according to ...
Takahiro Kinoshita, Eigo Akimoto, Masahiro Yura, Mitsumasa Yoshida   +3 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Clinical outcomes of single incision laparoscopic surgery for colorectal cancer: A propensity score‐matched analysis between well‐experienced and novice surgeons

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 102-109, January 2023., 2023
SILS is a technically challenging procedure for novice surgeons. We evaluate the clinical outcomes of SILS for colorectal cancer performed by novice surgeons. SILS was safely performed by novice surgeons under the guidance of well‐experienced surgeons, and could provide satisfactory oncological outcomes. Abstract Background Single incision laparoscopic
Mitsuyoshi Tei, Yozo Suzuki, Masahisa Ohtsuka, Kazuya Iwamoto, Atsushi Naito, Mitsunobu Imasato, Tsunekazu Mizushima, Hiroki Akamatsu   +7 more
wiley   +1 more source

Impact of adjuvant chemotherapy on patients with ypT0–2 ypN0 rectal cancer after neoadjuvant chemoradiation: a cohort study from a tertiary referral hospital

World Journal of Surgical Oncology, 2018
Background To investigate the importance of adjuvant chemotherapy in locally advanced rectal cancer (≥ cT3 or N+) staged ypT0–2 ypN0 on final histological work-up after neoadjuvant chemoradiation and radical resection.
Christian Galata, Kirsten Merx, Sabine Mai, Timo Gaiser, Frederik Wenz, Stefan Post, Peter Kienle, Ralf-Dieter Hofheinz, Karoline Horisberger   +8 more
doaj   +1 more source

Impact of adjuvant chemotherapy for radically resected esophageal squamous cell carcinoma: a propensity score matching analysis

Frontiers in Surgery, 2023
BackgroundThe aim of this study was to evaluate the impact of adjuvant chemotherapy in patients with radically resected esophageal squamous cell carcinoma (ESCC).MethodsPatients with esophageal cancer who underwent esophagectomy at our hospital from 2010
Shao-bin Chen, Di-tian Liu, Yu-ping Chen
doaj   +1 more source