Results 91 to 100 of about 38,260 (246)

Impact of RAS/RAF Mutations on Metastatic Treatment Response Following Total Neoadjuvant Therapy in Patients With Stage IV Rectal Cancer

Asia-Pacific Journal of Clinical Oncology, EarlyView.
There is limited understanding of the impact of underlying RAS/RAF mutational status on total neoadjuvant therapy metastatic tumor response rates in curative Stage IV rectal cancer patients. Complete metastatic tumor response to TNT was demonstrated in half as many mRAS as wtRAS patients and disease progression was higher in patients harboring RAS ...
Tracy R. Fitzsimmons, Z. Bunjo, E. L. Neo, A. Badiei, M. Penniment, S. Selva‐Nayagam, A. Ruszkiewicz, J. Wong, T. Sammour   +8 more
wiley   +1 more source

Ramosetron hydrochloride for the prevention of cancer chemotherapy induced nausea and vomiting: The Indian experience

South Asian Journal of Cancer, 2014
Background: Despite the advent of 5-HT 3 antagonists, control of delayed gastrointestinal adverse events with cancer chemotherapy is still not optimal.
Jayesh J Sanmukhani, Prafulla Pawar, Ravindra Mittal   +2 more
doaj   +1 more source

Pharmaceutical policy and off‐label prescribing in pregnancy: A population‐based historical cohort study analyzing inequality in access to antiemetics within Australia's Pharmaceutical Benefits Scheme

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Public spending on antiemetics among pregnant women in Australia is concentrated in socioeconomically disadvantaged women. However, public expenditure is also driven by off‐label ondansetron use (i.e., use outside regulatory‐approved indications), highlighting a misalignment between pharmaceutical policy, public expenditure patterns, and pregnant women'
Hannah Jackson, Luke Grzeskowiak, Joanne Enticott, Sarah Wise, Emily Callander   +4 more
wiley   +1 more source

Malnutrition and chemotherapy-induced nausea and vomiting: implications for practice [PDF]

, 2012
Purpose/Objectives: To determine the prevalence of malnutrition and chemotherapy-induced nausea and vomiting (CINV) limiting patients' dietary intake in a chemotherapy unit. Design: Cross-sectional descriptive audit. Setting: Chemotherapy ambulatory care
McCarthy, Alexandra Leigh, Ferguson, Maree, Isenring, Elisabeth, Vick, Joanna, McCarthy, Alexandra, Isenring, Elisabeth A., Davidson, Wendy, Muller, Jacqueline, McCarthy, Alexandra L., Teleni, Laisa, Vick, Jo   +10 more
core   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, EarlyView.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Management of acute and delayed chemotherapy-induced nausea and vomiting: role of netupitant–palonosetron combination [PDF]

, 2016
Piotr K JanickiDepartment of Anesthesiology and Perioperative Medicine, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA, USAPurpose: The purpose of this review is to summarize and discuss the recently ...
Janicki PK
core  

Risk Factors Associated with Chemotherapy-Induced Nausea and Vomiting Among Women with Breast Cancer Receiving Highly Emetogenic Chemotherapy:Individual Patient-Based Analysis of Three Prospective Antiemetic Trials [PDF]

Purpose: Although risk factors related to chemotherapy-induced nausea and vomiting (CINV) have been identified in previous studies, only a few studies have evaluated the risk factors associated with contemporary antiemetic prophylaxis, including ...
Mo, Frankie K.F., Lau, Thomas K.H., Ko, Jonathan W.H., Ngai, Nicole T.Y., Kwok, Carol Chi Hei, Yeo, Horatio L., Yip, Claudia H.W., Molassiotis, Alex, Yip, CHristopher C.H., Pang, Elizabeth, Yeo, Winnie, Ko, Stephanie W.Y., Yeo, Victoria A., Lai, Kwai Tung, Li, Leung V.   +14 more
core   +1 more source

Effect of non-pharmacological interventions on chemotherapy induced delayed nausea and vomiting for tumors: A systematic review and Bayesian network meta-analysis

Complementary Therapies in Medicine
Objective: To evaluate the efficacy of non-pharmacological interventions in improving chemotherapy induced delayed nausea and vomiting symptoms using a network meta-analysis. Methods: Four Chinese databases (CNKI, Wanfang Data Knowledge Service Platform,
Yongni Wang, Fang Wang, Feifei Hu, Fang Long   +3 more
doaj   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, EarlyView.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Olanzapine in Chemotherapy Induced Nausea and Vomiting [PDF]

, 2021
: Objective: Patients diagnosed with cancer and undergoing chemotherapeutic regimen often anticipate many negative effects of the therapy. Chemotherapy induced nausea and vomiting is of their principal concerns which remains one of the most unpleasant ...
Hussain, Syed Saad, Iqbal, Sarmad, Rahman, Fasiha Abdul   +2 more
core