Results 101 to 110 of about 2,538,615 (320)

A mathematical justification for metronomic chemotherapy in oncology [PDF]

arXiv, 2021
We mathematically justify metronomic chemotherapy as the best strategy to apply most cytotoxic drugs in oncology for both curative and palliative approaches, assuming the classical pharmacokinetic model together with the Emax pharmacodynamic and the Norton-Simon hypothesis.
arxiv  

Adjuvant chemotherapy with or without bevacizumab in patients with resected non-small-cell lung cancer (E1505): an open-label, multicentre, randomised, phase 3 trial. [PDF]

, 2017
BackgroundAdjuvant chemotherapy for resected early-stage non-small-cell lung cancer (NSCLC) provides a modest survival benefit. Bevacizumab, a monoclonal antibody directed against VEGF, improves outcomes when added to platinum-based chemotherapy in ...
Adjei, Alex A, Aisner, Seena C, Butts, Charles, Chapman, Andrew E, Dahlberg, Suzanne E, ECOG-ACRIN, Evans, Tracey, Gandara, David R, Graziano, Stephen L, Horn, Leora, Kasbari, Samer S, Keller, Steven M, Leighl, Natasha B, McDermott, Sean R, Patel, Jyoti D, Perez-Soler, Roman, Ramalingam, Suresh S, Rothman, Jan M, Sborov, Mark D, Schiller, Joan H, Shafqat, Atif, Tester, William J, Traynor, Anne M, Wakelee, Heather A   +23 more
core   +1 more source

Ceftaroline fosamil – fifth-generation cephalosporin with anti-MRSA activity in the treatment of severe infections in pediatric practice [PDF]

Клиническая микробиология и антимикробная химиотерапия
Сeftaroline fosamil is a fifth-generation cephalosporin and a unique β-lactam and the only currently registered in the Russian Federation cephalosporin with activity against MRSA. Сeftaroline is approved for use in pediatric practice for the treatment of
Andreeva I.V., Stetsiouk O.U., Kozlov R.S.   +2 more
doaj   +1 more source

SGK1 mutation status can further stratify patients with germinal center B‐cell‐like diffuse large B‐cell lymphoma into different prognostic subgroups

Cancer Medicine, 2022
There are over a 100 driver gene mutations in patients with diffuse large B‐cell lymphoma (DLBCL), but their clinical significance remains unclear. Here, we first analyzed the DLBCL dataset from the UK‐based Haematological Malignancy Research Network ...
Baoping Guo, Yujie Huang, Ying Duan, Chengcheng Liao, Hong Cen   +4 more
doaj   +1 more source

DNA repair biomarkers XPF and phospho-MAPKAP kinase 2 correlate with clinical outcome in advanced head and neck cancer. [PDF]

, 2014
BackgroundInduction chemotherapy is a common therapeutic option for patients with locoregionally-advanced head and neck cancer (HNC), but it remains unclear which patients will benefit. In this study, we searched for biomarkers predicting the response of
Cohen, Ezra EW, Farrow, Allan D, Finn, Stephen, Heitmann, Jana, Lingen, Mark W, O'Regan, Esther, Seiwert, Tanguy Y, Sprott, Kam, Stenson, Kerstin, Villegas-Bergazzi, Vivian, Vokes, Everett E, Wang, XiaoZhe, Weaver, David T, Weichselbaum, Ralph R   +13 more
core   +2 more sources

Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer.

Journal of Clinical Oncology, 2020
PURPOSE Patients with advanced esophageal cancer have a poor prognosis and limited treatment options after first-line chemotherapy. PATIENTS AND METHODS In this open-label, phase III study, we randomly assigned (1:1) 628 patients with advanced ...
T. Kojima, Manish A. Shah, K. Muro, E. François, A. Adenis, Chih-Hung Hsu, T. Doi, T. Moriwaki, Sung-Bae Kim, Se-Hoon Lee, J. Bennouna, Ken Kato, L. Shen, P. Enzinger, S. Qin, P. Ferreira, Jia Chen, G. Girotto, C. de la Fouchardière, H. Sénellart, R. Al-Rajabi, F. Lordick, Rui-xue Wang, S. Suryawanshi, P. Bhagia, S. Kang, J. Metges   +26 more
semanticscholar   +1 more source

Modeling Three-dimensional Invasive Solid Tumor Growth in Heterogeneous Microenvironment under Chemotherapy [PDF]

, 2018
A systematic understanding of the evolution and growth dynamics of invasive solid tumors in response to different chemotherapy strategies is crucial for the development of individually optimized oncotherapy. Here, we develop a hybrid three-dimensional (3D) computational model that integrates pharmacokinetic model, continuum diffusion-reaction model and
arxiv   +1 more source

Perceived Cognitive Changes with Chemotherapy for Breast Cancer: A Pilot Study [PDF]

, 2016
Purpose The purpose of this study was to determine perceived cognitive functioning, fatigue, depression and general well-being among women before and after the initiation of chemotherapy for breast cancer compared to a sample of healthy women.
Bloom, Alan S., Fitzgerald, Judith, Haberlein, Sara, Piacentine, Linda B.   +3 more
core   +1 more source

Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity. [PDF]

, 2014
A major impediment to the response of tumors to chemotherapy is that the large majority of cancer cells within a tumor are quiescent in G0/G1, where cancer cells are resistant to chemotherapy.
Bouvet, Michael, Fujiwara, Toshiyoshi, Han, Qinghong, Hoffman, Robert M, Li, Shukuan, Tan, Yuying, Yano, Shuya   +6 more
core   +3 more sources

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma [PDF]

, 2003
BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used
A du Bois, A Villa, Alan Lamont, AN Gordon, Andrew C Hindley, B Lund, Bernard R Higgins, Christian M Kurbacher, CM Kurbacher, CM Kurbacher, DD Von Hoff, DD Von Hoff, DL Clarke-Pearson, DS Ettinger, EM Hunter, Federica Di Nicolantonio, G Blackledge, G Konecny, GJ Rustin, GJ Rustin, IA Cree, IA Cree, IA Cree, Ian A Cree, J Kaern, JS Berek, JT Thigpen, KA Donovan, Louise A Knight, M Breidenbach, M Breidenbach, M Gore, M Harries, M Markman, M Markman, M Markman, M Markman, Martin Gore, ME Gore, ME Gore, ME van der Burg, MH Neale, Michael H Neale, MJ Piccart, ML Hensley, N Myatt, OM Grecu, P Hanjani, P Therasse, Pauline A Whitehouse, PE Andreotti, PG Rose, RD Petty, Richard Osborne, Robert T. Greenlee, Sanjay Sharma, Stuart J Mercer, T Meyer, U Kurbacher CM Stier, WP McGuire   +59 more
core   +4 more sources