Resected Pancreatic Cancer With N2 Node Involvement Is Refractory to Gemcitabine-Based Adjuvant Chemotherapy [PDF]
, 2020 Chen Liu +10 more
openalex +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Nature Communications, 2019 The treatment of ROS1-rearranged non-small cell lung cancer with the TKI crizotinib is limited due to the emergence of resistance. Here, the authors develop a new ROS1/NTRK inhibitor, DS-6051b, which overcomes crizotinib resistance in preclinical models.
Ryohei Katayama +23 more
doaj +1 more source
Dosimetric advantage of volumetric modulated arc therapy in the treatment of intraocular cancer
Radiation Oncology, 2017 Objective The purpose of this study is to investigate the dosimetric advantages of volumetric modulated arc therapy (VMAT) in the treatment of intraocular cancer by comparing it directly with three-dimensional conformal radiotherapy (CRT) and intensity ...
Zhenxiang Deng +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern +7 more
wiley +1 more source
Epidemiological characteristic of Streptococcus pneumoniae serotypes from patients with invasive pneumococcal disease in the Russian Federation [PDF]
Клиническая микробиология и антимикробная химиотерапияObjective. To characterize spectrum of S. pneumoniae serotypes isolated from patients with invasive pneumococcal infection in the Russian Federation. Materials and Methods. The serotype identification of 93 S.
Muravyev A.A. +5 more
doaj +1 more source
Intensive Dose-Dense Compared With Conventionally Scheduled Preoperative Chemotherapy for High-Risk Primary Breast Cancer [PDF]
, 2009 Michael Untch +19 more
openalex +1 more source
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma.
New England Journal of Medicine, 2019 BACKGROUND Platinum-based concurrent chemoradiotherapy is the standard of care for patients with locoregionally advanced nasopharyngeal carcinoma. Additional gemcitabine and cisplatin induction chemotherapy has shown promising efficacy in phase 2 trials.
Y. Zhang +46 more
semanticscholar +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
In vitro Ceftaroline Activity against Major Bacterial Pathogens n Russia: Results of Multicenter Study [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2015 Background. Ceftaroline is a new broad-spectrum cephalosporin with in vitro activity against Gram-positive pathogens, including MRSA, and common Gram-negative pathogens.
Kozlov R.S. +11 more
doaj