Results 21 to 30 of about 2,047,581 (349)
Increased survival with enzalutamide in prostate cancer after chemotherapy.
New England Journal of Medicine, 2012 BACKGROUND Enzalutamide (formerly called MDV3100) targets multiple steps in the androgen-receptor-signaling pathway, the major driver of prostate-cancer growth.
H. Scher +19 more
semanticscholar +1 more source
Journal of Clinical Oncology, 2023 Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available.
S. Novello +17 more
semanticscholar +1 more source
Candidate genes in gastric cancer identified by constructing a weighted gene co-expression network [PDF]
PeerJ, 2018 Background Gastric cancer (GC) is one of the most common cancers with high mortality globally. However, the molecular mechanisms of GC are unclear, and the prognosis of GC is poor.
Jian Chen +5 more
doaj +2 more sources
New England Journal of Medicine, 2002 BACKGROUND The survival of patients with diffuse large-B-cell lymphoma after chemotherapy is influenced by molecular features of the tumors. We used the gene-expression profiles of these lymphomas to develop a molecular predictor of survival.
A. Rosenwald +39 more
semanticscholar +1 more source
Mechanisms of Multidrug Resistance in Cancer Chemotherapy
International Journal of Molecular Sciences, 2020 Cancer is one of the main causes of death worldwide. Despite the significant development of methods of cancer healing during the past decades, chemotherapy still remains the main method for cancer treatment. Depending on the mechanism of action, commonly
K. Bukowski, M. Kciuk, R. Kontek
semanticscholar +1 more source
Journal of Clinical Oncology, 2021 PURPOSE We report the first 5-year follow-up of any first-line phase III immunotherapy trial for non–small-cell lung cancer (NSCLC). KEYNOTE-024 (ClinicalTrials.gov identifier: NCT02142738) is an open-label, randomized controlled trial of pembrolizumab ...
M. Reck +18 more
semanticscholar +1 more source
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer.
New England Journal of Medicine, 2013 BACKGROUND In single-group studies, chromosomal rearrangements of the anaplastic lymphoma kinase gene (ALK) have been associated with marked clinical responses to crizotinib, an oral tyrosine kinase inhibitor targeting ALK. Whether crizotinib is superior
A. Shaw +22 more
semanticscholar +1 more source
The known-unknown: third- and fourth-generation cephalosporins combined with sulbactam [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2023 Despite the presence of more than 100 different antibacterials in the therapeutic arsenal, beta-lactam antibiotics, in general, and the third-generation cephalosporins, in particular, remain the main option for the treatment of the most of infections in ...
Stetsiouk O.U. +3 more
doaj +1 more source
A Retrospective Data Analysis of the Structure of Isolated Microorganisms in Secondary Skin and Soft Tissue Infections Using Permuted Test [PDF]
Клиническая микробиология и антимикробная химиотерапия, 2016 Objective. Objectives. To analyze the structure of microorganisms isolated in patients with secondary skin and soft tissues infection (SSTIs) (trophic ulcers in patients with diabetes mellitus (DM), chronic arterial insufficiency (CAI), chronic venous ...
Kuzmenkov A.Yu. +5 more
doaj
In vitro activity of macrolides against Streptococcus pneumoniae and Streptococcus pyogenes in the Russian Federation: “Status praesens” [PDF]
Клиническая микробиология и антимикробная химиотерапияObjective. To evaluate in vitro activity of various macrolide antibiotics against a current collection of clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes isolated from patients with community-acquired infections in different ...
Kozlov R.S. +3 more
doaj +1 more source