Results 201 to 210 of about 9,484 (238)

A new chemotype of Scoparia dulcis

Phytochemistry, 1993
Abstract A new chemotype was found in Scoparia dulcis from Taiwan, China and Thailand based on the diterpene composition. The new chemotype was characterized by the presence of scopadulciol and scopadiol. The structure of a new diterpene was determined to be 6-benzoyl-labda-8(17),13-diene-15,18-diol by spectroscopic methods.
Toshimitsu Hayashi, Akira Iida, Naokata Morita   +2 more
exaly   +2 more sources

Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype

Bioorganic & Medicinal Chemistry Letters, 2006
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. A previous study of the diketoacid-based chemotype suggested that there are two aryl-binding domains on integrase. In this study, modifications to the indole-based diketoacid chemotype are explored.
Michael A, Walker, Timothy, Johnson, Zhuping, Ma, Yunhui, Zhang, Jacques, Banville, Roger, Remillard, Serge, Plamondon, Annapurna, Pendri, Henry, Wong, Daniel, Smith, Albert, Torri, Himadri, Samanta, Zeyu, Lin, Carol, Deminie, Brian, Terry, Mark, Krystal, Nicholas, Meanwell   +16 more
openaire   +2 more sources

New chemotypes for cathepsin K inhibitors

Bioorganic & Medicinal Chemistry Letters, 2008
Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.
Naoki, Teno, Osamu, Irie, Takahiro, Miyake, Keigo, Gohda, Miyuki, Horiuchi, Sachiyo, Tada, Kazuhiko, Nonomura, Motohiko, Kometani, Genji, Iwasaki, Claudia, Betschart   +9 more
openaire   +2 more sources

CHEMOTYPES OF FUSOBACTERIUM NUCLEATUM LIPOPOLYSACCHARIDES

Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1978
Lipopolysaccharides (LPS) were isolated from 20 strains of Fusobacterium nucleatum and examined by paper chromatography. gas liquid chromatography and colorimetric methods for the presence of neutral sugars, amino sugars and 2‐keto‐3‐deoxy‐octonate (KDO). The LPS had in common glucosamine, L‐glycero‐D‐manno‐heptose. glucose and KDO. The KDO content was
G, Fredriksen, T, Hofstad
openaire   +2 more sources

Function and Chemotypes of Human Hsp70 Chaperones

Current Topics in Medicinal Chemistry, 2016
In humans, Hsp70 chaperones are ubiquitously expressed in the cytosol, endoplasmic reticulum and mitochondria. They fulfill important roles in protein folding and the protection of cells from stress. Different forms of Hsp70 have also been found to regulate specific signaling pathways, many related to cell death.
Liza, Shrestha, Jason C, Young
openaire   +2 more sources

Chemotyping of yeast mutants using robotics

Yeast, 1999
By now, the EUROFAN programme for the functional analysis of genes from the yeast genome has attained its cruising speed. Indeed, several hundreds of yeast mutants with no phenotype as tested by growth on standard media and no significant sequence similarity to proteins of known function are available through the efforts of various laboratories.
K J, Rieger, M, El-Alama, G, Stein, C, Bradshaw, P P, Slonimski, K, Maundrell   +5 more
openaire   +2 more sources

CHEMOTYPES OF VEILLONELLA LIPOPOLYSACCHARIDES

Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1978
Lipopolysaccharides (LPS) were isolated by phenol‐water extraction from 34 strains of Veillonella. and examined by paper chromatography and colorimetric methods for the presence of neutral sugars, amino sugars and 2‐keto‐3‐deoxy‐octonate (KDO). Several preparations were also examined for neutral sugars by gas liquid chromatography.
openaire   +2 more sources

Better than Random? The Chemotype Enrichment Problem

Journal of Chemical Information and Modeling, 2009
Chemotype enrichment is increasingly recognized as an important measure of virtual screening performance. However, little attention has been paid to producing metrics which can quantify chemotype retrieval. Here, we examine two different protocols for analyzing chemotype retrieval: "cluster averaging", where the contribution of each active to the ...
Mark D. Mackey, James L. Melville
openaire   +2 more sources

Studies on Chemotypes of Cinnamomum Camphora

Advanced Materials Research, 2011
Gas chromatography coupled with mass spectrometry (GC-MS) was applied to analyze the essential oil extracted from the leaves of 50 individual plants of Cinnamomum camphora, which were collected from the same mountain in Jiangxi province of China. 32 peaks in total were identified in these samples, which were then categorized into five chemotypes ...
Yong Ming Luo, Shi Rong Li, Xiao Yin Yin
openaire   +1 more source

A chemotype of Cyperus rotundus in Hawaii

Phytochemistry, 1989
Abstract A new chemotype of Cyperus rotundus was found in Hawaii based on the sesquiterpene composition of the mature tubers. The K-type has higher concentrations of patchoulenyl acetate and sugeonyl acetate than the three known Asian chemotypes. Biochemical and evolutionary aspects of these findings are discussed.
Koichiro Komai, Chung-Shih Tang
openaire   +1 more source