Results 211 to 220 of about 19,491 (256)

Diaryl Ureas as an Antiprotozoal Chemotype

ACS Infectious Diseases, 2021
We now describe the physicochemical profiling, in vitro ADME, and antiparasitic activity of eight N,N'-diarylureas to assess their potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were ≤6.3 μg/mL, and plasma protein binding ranged from 95 to 99%.
Derek A. Leas, Austin G. Sanford, Jianbo Wu, Monica Cal, Marcel Kaiser, Sergio Wittlin, Ryan M. Hemsley, Elyssa B. Darner, LeeAnna M. Lui, Paul H. Davis, Jonathan L. Vennerstrom   +10 more
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Lipopolysaccharide chemotypes of Burkholderia cepacia

Journal of Medical Microbiology, 1999
Burkholderia cepacia is an important pathogen in patients with cystic fibrosis (CF) and much is now known of its epidemiology. In contrast, its virulence mechanisms are poorly understood. The lipopolysaccharide (LPS) of B. cepacia, a well-recognised virulence factor of other gram-negative bacteria, is known to be strongly endotoxic in vitro. The aim of
Elwyn, Evans, Ian R, Poxton, John R W, Govan   +2 more
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Chemotypic Variation in Indian Spearmint*

Planta Medica, 1989
Our investigation has substantiated that Indian spearmint exists in the form of three chemotypes, the common one being rich in limonene and carvone while the other two being rich in piperitenone ...
L N, Misra, B R, Tyagi, R S, Thakur
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A Study on Tansy Chemotypes

Planta Medica, 1987
According to Scheu (5), a "pure chemical race" is defined using one oil component, which can be unequivocally considered as the main component. However, another way of defining a chemotype is to observe the whole peak distribution of the chromatogram (6).
M, Holopainen, R, Hiltunen, M, von Schantz   +2 more
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New chemotypes for cathepsin K inhibitors

Bioorganic & Medicinal Chemistry Letters, 2008
Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.
Naoki, Teno, Osamu, Irie, Takahiro, Miyake, Keigo, Gohda, Miyuki, Horiuchi, Sachiyo, Tada, Kazuhiko, Nonomura, Motohiko, Kometani, Genji, Iwasaki, Claudia, Betschart   +9 more
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CHEMOTYPES OF FUSOBACTERIUM NUCLEATUM LIPOPOLYSACCHARIDES

Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1978
Lipopolysaccharides (LPS) were isolated from 20 strains of Fusobacterium nucleatum and examined by paper chromatography. gas liquid chromatography and colorimetric methods for the presence of neutral sugars, amino sugars and 2‐keto‐3‐deoxy‐octonate (KDO). The LPS had in common glucosamine, L‐glycero‐D‐manno‐heptose. glucose and KDO. The KDO content was
G, Fredriksen, T, Hofstad
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Chemotyping of yeast mutants using robotics

Yeast, 1999
By now, the EUROFAN programme for the functional analysis of genes from the yeast genome has attained its cruising speed. Indeed, several hundreds of yeast mutants with no phenotype as tested by growth on standard media and no significant sequence similarity to proteins of known function are available through the efforts of various laboratories.
K J, Rieger, M, El-Alama, G, Stein, C, Bradshaw, P P, Slonimski, K, Maundrell   +5 more
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Better than Random? The Chemotype Enrichment Problem

Journal of Chemical Information and Modeling, 2009
Chemotype enrichment is increasingly recognized as an important measure of virtual screening performance. However, little attention has been paid to producing metrics which can quantify chemotype retrieval. Here, we examine two different protocols for analyzing chemotype retrieval: "cluster averaging", where the contribution of each active to the ...
Mark D, Mackey, James L, Melville
openaire   +2 more sources

CHEMOTYPES OF VEILLONELLA LIPOPOLYSACCHARIDES

Acta Pathologica Microbiologica Scandinavica Section B Microbiology, 1978
Lipopolysaccharides (LPS) were isolated by phenol‐water extraction from 34 strains of Veillonella. and examined by paper chromatography and colorimetric methods for the presence of neutral sugars, amino sugars and 2‐keto‐3‐deoxy‐octonate (KDO). Several preparations were also examined for neutral sugars by gas liquid chromatography.
openaire   +2 more sources

Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype

Bioorganic & Medicinal Chemistry Letters, 2006
Integrase is one of three enzymes expressed by HIV and represents a validated target for therapy. A previous study of the diketoacid-based chemotype suggested that there are two aryl-binding domains on integrase. In this study, modifications to the indole-based diketoacid chemotype are explored.
Michael A, Walker, Timothy, Johnson, Zhuping, Ma, Yunhui, Zhang, Jacques, Banville, Roger, Remillard, Serge, Plamondon, Annapurna, Pendri, Henry, Wong, Daniel, Smith, Albert, Torri, Himadri, Samanta, Zeyu, Lin, Carol, Deminie, Brian, Terry, Mark, Krystal, Nicholas, Meanwell   +16 more
openaire   +2 more sources