Results 181 to 190 of about 15,517 (273)

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source

Molecular LEGION: incalculably large coverage of chemical space around the NLRP3 target. [PDF]

Sci Data
Zagribelnyy B, Aladinskiy V, Bondarev N, Ilin I, Malkov M, Vasileva A, Ding X, Lin A, Shayakhmetov R, Aliper A, Ren F, Zhavoronkov A.   +11 more
europepmc   +1 more source

Development and Evaluation of Natural Hydrogel Nanocomposites for Skin Rejuvenation: Design and Optimization of Effective Formulations

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background This study examines the development of innovative hydrogel nanocomposites from natural, biocompatible materials to rejuvenate skin and slow aging. Aim To develop two distinct formulations to counteract internal and external aging factors.
Mahsa Ahankoob Nezhad, Akbar Esmaeili, Maryam Beladi   +2 more
wiley   +1 more source

Structure-guided discovery of non-catechol dopamine D1 receptor ligands with biased agonism and antagonism. [PDF]

J Biol Chem
Zhou Y, Wetsel WC, Kahsai AW, Olson SH, Barak LS.   +4 more
europepmc   +1 more source

Constitutive and inducible oleoresin defenses share genetic architectures and mechanisms in Pinus taeda

New Phytologist, Volume 250, Issue 5, Page 2966-2987, June 2026.
Summary The oleoresin defense system of loblolly pine (Pinus taeda) protects trees from insects and pathogens and is an important source of renewable biofuels and chemicals, but the genetic basis of oleoresin production is poorly understood. We characterized the genetic architecture of oleoresin flow, resin canal number, stem wood terpene content, and ...
Mallory M. Morgan, Jared Westbrook, Christopher Dervinis, Tania Quesada, Salvador Gezan, Robert Sykes, Timothy S. Johnson, Gabriela Madrid, Matthew Lane, Alice Townsend, Thomas A. Colquhoun, John M. Davis, Daniel Jacobson, Gary F. Peter   +13 more
wiley   +1 more source

Antifungal Potential of Essential Oil Chemotypes of Eugenia uniflora Against Phytopathogens. [PDF]

Chem Biodivers
Moreira YN, Duarte-Junior EB, Fontes IS, de Medeiros EADP, Pereira CDSB, Alves DDP, Mariano-Junior DR, Cavalcante RS, Damasceno-Junior PC, Santos AMD, de Souza MAA.   +10 more
europepmc   +1 more source

[Chemotypes of Pseudomonas aeruginosa].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 1988
E S, Stanislavskiĭ, B, Lányi, Iu A, Knirel', B A, Dmitriev   +3 more
openaire   +1 more source

The BAHD Acyltransferase Gene Family: Evolutionary Dynamics, Biochemical Mechanisms, and Roles in Plant Stress Adaptation

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4139-4158, June 2026.
BAHD acyltransferases drive metabolic diversification in plants by coupling conserved catalytic scaffolds with regulatory flexibility, enabling stress adaptation and ecological specialisation. ABSTRACT BAHD acyltransferases constitute one of the most versatile enzyme superfamilies in plants, catalysing the acylation of alcohols, amines, polyamines, and
Muhammad Mubashar Zafar, Qiao Fei, Abdul Razzaq, Ayesha Siddiqua, Ayesha Naveed, M. Nasir Khan, Huma Saleem, Xuefei Jiang   +7 more
wiley   +1 more source

High-throughput phenotypic screening of Medicines for Malaria Venture's Hit Generation Library 1 identifies new nematocidal chemotypes. [PDF]

Int J Parasitol Drugs Drug Resist
Taki AC, Byrne JJ, Chang BCH, Laleu B, Wells TNC, Jabbar A, Gasser RB.   +6 more
europepmc   +1 more source

[Bacterial chemotypes in epidemiology].

Bulletin de l'Academie veterinaire de France, 1971
L, Joubert, J, Buissière
openaire   +1 more source