Results 201 to 210 of about 24,382 (256)

Editorial: Targeting major human fungal pathogens: novel insights into virulence and antifungal therapies. [PDF]

Front Cell Infect Microbiol
Sun T, Li H, Zhang Y.
europepmc   +1 more source

AI-Augmented Iterative Screening of Libraries Against RNA Targets (AISLAR) Boosts Discovery of SAR-Tractable RNA Binders and Rational Analog Design. [PDF]

Small Sci
Hattori H, Otsu M, Imai K, Narahara M, Kondo J, Shino A, Morishita EC.   +6 more
europepmc   +1 more source

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Diaryl Ureas as an Antiprotozoal Chemotype

ACS Infectious Diseases, 2021
We now describe the physicochemical profiling, in vitro ADME, and antiparasitic activity of eight N,N'-diarylureas to assess their potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were ≤6.3 μg/mL, and plasma protein binding ranged from 95 to 99%.
Derek A. Leas, Austin G. Sanford, Jianbo Wu, Monica Cal, Marcel Kaiser, Sergio Wittlin, Ryan M. Hemsley, Elyssa B. Darner, LeeAnna M. Lui, Paul H. Davis, Jonathan L. Vennerstrom   +10 more
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Molecular Diversity Assessment using Chemotypes

Current Computer-Aided Drug Design, 2022
Background: Many techniques to design chemical libraries for screening have been put forward over time. General use libraries are still important when screening against novel targets, and their design has relied on the use of molecular descriptors. In contrast, chemotype or scaffold analysis has been used less often.
Hugo O. Villar, Raghav Mandayan, Mark R. Hansen   +2 more
openaire   +2 more sources

A Study on Tansy Chemotypes

Planta Medica, 1987
According to Scheu (5), a "pure chemical race" is defined using one oil component, which can be unequivocally considered as the main component. However, another way of defining a chemotype is to observe the whole peak distribution of the chromatogram (6).
M, Holopainen, R, Hiltunen, M, von Schantz   +2 more
openaire   +2 more sources