Diversity of Volatile Emissions From Cork Oak: Quantity and Quality Vary Independently Across Its Range. [PDF]
Staudt M, Rivet C, Erdogan M.
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Chemotype, maternal genotype, or field neighbors: what influences performance and resource allocation in a perennial plant species the most? [PDF]
Ziaja D +4 more
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LED Light Treatments Induce Activation of the Antioxidant Defense System in <i>Thymus mastichina</i> L. [PDF]
Cáceres-Cevallos GJ +3 more
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Cannabis: from crop to shop-some insights about stability to access quality control. [PDF]
da Costa-Oliveira C +7 more
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Climate Zone of Geographical Origin Associations with Essential Oil Composition, Yield, and Chemotype Distribution in <i>Coriandrum sativum</i> L.: A Multivariate Analysis of 48 Global Accessions. [PDF]
Kim M, Kim S.
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HIT101308137 and HIT104293658 nominate dual target chemotypes for PTPN1 and PTPN2 with preliminary selectivity in colorectal cancer cells. [PDF]
Huang C, Chen J, Chen R, Cao L.
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Diaryl Ureas as an Antiprotozoal Chemotype
ACS Infectious Diseases, 2021We now describe the physicochemical profiling, in vitro ADME, and antiparasitic activity of eight N,N'-diarylureas to assess their potential as a broad-spectrum antiprotozoal chemotype. Chromatographic LogD7.4 values ranged from 2.5 to 4.5; kinetic aq. solubilities were ≤6.3 μg/mL, and plasma protein binding ranged from 95 to 99%.
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Infusions and decoctions of three chemotypes of Lippia alba (Mill.) N. E. Brown (Verbenaceae) were investigated for their quantitative profiles by HPLC-DAD-ESI-MS analyses.
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Molecular Diversity Assessment using Chemotypes
Current Computer-Aided Drug Design, 2022Background: Many techniques to design chemical libraries for screening have been put forward over time. General use libraries are still important when screening against novel targets, and their design has relied on the use of molecular descriptors. In contrast, chemotype or scaffold analysis has been used less often.
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According to Scheu (5), a "pure chemical race" is defined using one oil component, which can be unequivocally considered as the main component. However, another way of defining a chemotype is to observe the whole peak distribution of the chromatogram (6).
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