Results 231 to 240 of about 16,871 (260)

Dissolution of Cholesterol Gallstones by Chenodeoxycholic Acid

New England Journal of Medicine, 1972
Abstract Seven women with gallstones were given 0.75 to 4.5 g per day of chenodeoxycholic acid, a primary bile acid, to promote micellar solubilization of cholesterol in bile. In Case 1 three stones that had remained unchanged in size during six years of observations disappeared after six months of treatment.
Johnson L. Thistle, Rudy G. Danzinger, Leslie J. Schoenfield, Alan F. Hofmann   +3 more
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Gallstone dissolution with chenodeoxycholic acid [PDF]

Klinische Wochenschrift, 1980
Out of 95 patients with radiolucent gallstones who enrolled in a clinical study with chenodeoxycholic acid (CDC) for gallstone dissolution 75 patients with cholecystolithiasis completed 12 months of treatment. As a side effect 31% of patients reported intermittent diarrhea which did not cause cessation of therapy or missing of work.
K. H. Holtermüller, P. Gilsdorf, Hans J. Weis   +2 more
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Chenodeoxycholic acid therapy in erythrohepatic protoporphyria

Journal of Hepatology, 1986
The short-term effect of chenodeoxycholic acid administration on the excretion of protoporphyrin was investigated in 5 patients suffering from erythrohepatic protoporphyria. Faeces were collected for 7 days, 10 ml of bile was sampled daily and blood was drawn every 2 to 3 days.
J. Willem O. van den Berg, J. H. Paul Wilson, A. Edixhoven-Bosdijk, Jan Van Hatturn, Harold Baart de la Faille   +4 more
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Treatment of Gallstones with Chenodeoxycholic Acid and Phenobarbital

New England Journal of Medicine, 1975
In a controlled trial, 36 patients with asymptomatic radiolucent gallstones were treated with chenodeoxycholic acid, 750 mg per day, phenobarbital, 180 mg per day, combination of both drugs, and placebo. After one year, chenodeoxycholic acid, phenobarbital and the combination, but not placebo, significantly decreased biliary cholesterol saturation. The
Leonard I. Goldstein, George G. Bonorris, A. Chung, Leslie J. Schoenfield, Daniel A. Lahana, M.J. Coyne   +5 more
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Treatment of cerebrotendinous xanthomatosis with chenodeoxycholic acid

Annals of Neurology, 1985
AbstractWe describe a patient with cerebrotendinous xanthomatosis who was treated for one year with chenodeoxycholic acid. Modest clinical improvement was accompanied by marked improvement in visual and brainstem auditory evoked potentials. Improved central nervous system function coincided with return of plasma and cerebrospinal fluid cholestanol ...
Carolyn L. Warner, Gerald Salen, Lewis P. Rowland, Timothy A. Pedley, Ronald G. Emerson   +4 more
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Chenodeoxycholic Acid: The British Experience

Hospital Practice, 1974
Clinical trials of CDCA as a medical alternative to cholecystectomy were suspended in Britain in 1973 after animal studies raised questions of the agent's potential hepatotoxicity. Individual patients are still being accepted for treatment, however, with the focus shifting to such questions as the minimal effective dose.
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Physical-chemical properties of chenodeoxycholic acid and ursodeoxycholic acid

Gastroenterologia Japonica, 1980
It is now relatively well established that chenodexoycholic acid (CDCA) and ursodeoxycholic acid (UDCA), which are 7-OH epimer, are cholesterol gallstone dissolving agent. We investigated physical-chemical properties of CDCA and UDCA with respect to critical micellar concentration (CMC), micellar molecular weights (MMW) and solubilizing power of ...
Tetsuo Hisadome, Hideaki Itoh, Terutsugu Nakama, Teiji Furusawa   +3 more
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Chenodeoxycholate: The Bile Acid. The Drug. A Review

The American Journal of the Medical Sciences, 1994
Chenodeoxycholate (3 alpha, 7 alpha-dihydroxy-5 beta-cholanic acid) is a primary bile acid directly synthesized from cholesterol. It is an amphipathic molecule, possessing both a hydrophobic side and a polar hydrophilic side, giving it the ability to solubilize lipids in a water environment.
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A New Non-enzymatic Route to Chenodeoxycholic Acid

Chemistry Letters, 1996
Abstract A novel route for the production of the chenodeoxycholic acid is described, based on the selective non-enzymatic reduction of dehydrocholic acid The relative reactivity scale was established to be in the order: 12-keto (1), 7-keto (2), 3-keto (17.5).
BORTOLINI, Olga, U. COVA, FANTIN, Giancarlo, MEDICI, Alessandro   +3 more
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GALLSTONE DISSOLUTION BY CHENODEOXYCHOLIC ACID

The Lancet, 1973
G. Duncan Bell, R. Hermon Dowling
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