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Chenodeoxycholic Acid: Uses and Limitations

Hospital Practice, 1979
Conclusions about the efficacy and safety of this agent for dissolving cholesterol gallstones must wait until late next year, when results of large clinical trials are available. But results from many studies are available, as are preliminary clinical data from trials of a possible alternative, ursodeoxycholic acid.
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Metabolism of chenodeoxycholic acid in hamsters

Lipids, 1976
AbstractThe study on the metabolism after oral administration of chenodeoxycholic acid‐24‐14C was performed by analysis of radioactivity that had appeared in bile and feces of male hamsters. The radioactive bile acids were analyzed by thin layer chromatography and identified by the isotope dilution method. In the bile of the hamsters with bile fistula,
T, Tateyama, K, Katayama
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TREATMENT OF GALLSTONES BY CHENODEOXYCHOLIC ACID

Medical Journal of Australia, 1980
Twenty-three patients with radiolucent gallstones in a functioning gallbladder were treated by orally administered chenodeoxycholic acid (750 mg/day) for periods ranging from six to 24 months. Complete dissolution of gallstones occurred in five patients, and partial dissolution occurred in four patients--an over-all response of 39%. Side effects of the
J, Toouli, P, Jablonski, J M, Watts
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Chenodeoxycholic Acid and Ursodeoxycholic Acid

1990
Cholelithiasis (gallstones) is a major medical and economic problem in the USA (Schoenfield, 1977; Schoenfield et al., 1981). It has been estimated to have a prevalence of 15 million women and five million men, and almost one million new cases are discovered each year (Ingelfinger, 1968; Friedman et al., 1966).
Robert A. Maxwell, Shohreh B. Eckhardt
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Chenodeoxycholic acid therapy in erythrohepatic protoporphyria

Journal of Hepatology, 1986
The short-term effect of chenodeoxycholic acid administration on the excretion of protoporphyrin was investigated in 5 patients suffering from erythrohepatic protoporphyria. Faeces were collected for 7 days, 10 ml of bile was sampled daily and blood was drawn every 2 to 3 days.
J, Van Hattum   +4 more
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Polymorphism of chenodeoxycholic acid.

Il Farmaco; edizione scientifica, 1978
Polymorphism of chenodeoxycholic acid was studied by differential thermal analysis and X-ray diffraction. Four polymorphic forms (three crystalline and one amorphous) were characterized.
G, Giuseppetti, M, Paciotti
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Chenodeoxycholic Acid: An Update on Its Therapeutic Applications.

Handbook of Experimental Pharmacology, 2019
S. Fiorucci, E. Distrutti
semanticscholar   +1 more source

Large-scale production of ursodeoxycholic acid from chenodeoxycholic acid by engineering 7α- and 7β-hydroxysteroid dehydrogenase

Bioprocess and biosystems engineering (Print), 2019
Xuan Zhang   +3 more
semanticscholar   +1 more source

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