Results 21 to 30 of about 384,301 (315)

Comparative Analysis of Therapeutic Efficacy and Adverse Reactions among Various Thrombolytic Agents

Toxics
Thrombosis is a major health concern that contributes to the development of several cardiovascular diseases and a significant number of fatalities worldwide.
Chenxi Xie, Naying Zheng, Mingmei Li, Zhiyang Zhang, Dongqin Huang, Meizhu Xiao, Dongdong Chen, Chengyong He, Zhenghong Zuo, Xintan Chen   +9 more
doaj   +1 more source

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Long‐Term Cardiovascular Risk and Management of Patients Recorded in Primary Care With Unattributed Chest Pain: An Electronic Health Record Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Most adults presenting with chest pain will not receive a diagnosis and be recorded with unattributed chest pain. The objective was to assess if they have increased risk of cardiovascular disease compared with those with noncoronary chest pain
Kelvin P. Jordan, Trishna Rathod‐Mistry, James Bailey, Ying Chen, Lorna Clarson, Spiros Denaxas, Richard A. Hayward, Harry Hemingway, Danielle A. van der Windt, Mamas A. Mamas   +9 more
doaj   +1 more source

Pathogenic Germline PALB2 and RAD50 Variants in Patients With Relapsed Ewing Sarcoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Approximately 10% of patients with Ewing sarcoma (EwS) have pathogenic germline variants. Here, we report two cases: first, a novel germline pathogenic variant in partner and localizer of BRCA2 (PALB2) in a patient with a late EwS relapse. Its impact on homologous recombination is demonstrated, and breast cancer risk is discussed.
Molly Mack, A. Carolina Tufino, Mohd Azrin Jamalruddin, Sreya Dey, Yinghong Pan, Elina Mukherjee, Jessica D. Daley, Julia Meade, Mahmoud Aarabi, Lisa Maurer, James Cooper, Kara A. Bernstein, Kelly M. Bailey   +12 more
wiley   +1 more source

Vaspin alleviates pathological cardiac hypertrophy by regulating autophagy-dependent myocardial senescence

Emergency and Critical Care Medicine
. Background. Visceral adipose tissue–derived serine protease inhibitor (vaspin), a secretory adipokine, protects against insulin resistance. Recent studies have demonstrated that serum vaspin levels are decreased in patients with coronary artery disease
Haiying Rui, Huaxiang Yu, Dan Zou, Kai Chi, Ping Xu, Xiaoshuai Song, Lulu Liu, Xuting Wu, Jinxin Wang, Li Xue   +9 more
doaj   +1 more source

Chest Pain Relieved with a Bronchodilator or Other Asthma Drugs

Allergology International, 2009
Background: Although many patients who experience chest pain or pressure consult their physicians, unfortunately a large number of them do not, and consequently they remain undiagnosed and untreated.
Hirokazu Taniguchi, Kenta Kanbara, Kiyoshi Hoshino, Saburo Izumi   +3 more
doaj   +1 more source

Early identification of sepsis-induced coagulopathy in critical ill patients: an analysis from MIMIC IV database

BMC Infectious Diseases
Background To develop a model for early identification of coagulopathy in septic patients. Methods Patients with sepsis were identified from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Patients who did not meet the sepsis-induced
Yiming Dong, Nana Cao, Jinlei Wu, Xilong Liu, Xuyang Ji, Xiaofei Yin, Shuo Wu, Bailu Wang, Shujian Wei, Yuguo Chen   +9 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

ALDH2 mediates the effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) on improving cardiac remodeling

Cardiovascular Diabetology
Background Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are now recommended for patients with heart failure, but the mechanisms that underlie the protective role of SGLT2i in cardiac remodeling remain unclear.
Han Liu, Bingchen Jiang, Rui Hua, Xuehao Liu, Bao Qiao, Xiangxin Zhang, Xilong Liu, Wenjun Wang, Qiuhuan Yuan, Bailu Wang, Shujian Wei, Yuguo Chen   +11 more
doaj   +1 more source

Using HEART2 score to risk stratify chest pain patients in the Emergency Department: an observational study [PDF]

, 2022
Chet D. Schrader, Darren Kumar, Yuan Zhou, Stefan H. Meyering, Nicholas Saltarelli, Naomi Alanis, Chukwuagozie Iloma, Rebecca Smiley, Hao Wang   +8 more
openalex   +1 more source