Results 51 to 60 of about 6,019 (285)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Frequency, Clinical Presentation and Risk Factors of Carcinoma of Cheek in Patients Presenting at JPMC Karachi

Journal of the Dow University of Health Sciences, 2022
Objective: To assess the frequency, clinical presentation, and associated risk factors of carcinoma cheek in patients presenting at Ear, Nose, and Throat (ENT) department at Jinnah Postgraduate Medical Centre (JPMC), Karachi.
Muhammad Razzaq Dogar, Abdul Waheed, Ikram Ullah, Hurtamina Khan, Ghulam Shabir Mahar, Zubair Anwar   +5 more
doaj   +2 more sources

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Erosive potential of children’s chewable vitamin supplements: An in vitro investigation [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects
Background. Chewable vitamins are dietary supplements in which vitamins are combined with a flavor that appeals to children. The acidic nature of some vitamins and some flavoring agents may cause dental erosion.
Wannee Lertsooksawat, Yanisa Tanjaruphan, Thanawat Chaima, Thanawat Lerdpibulchai, Tanawan Wittayathawornwong, Chayada Teanchai, Rudee Surarit, Sivaporn Horsophonphong   +7 more
doaj   +1 more source

Formulation and Evaluation of Chewable Tablets from Natural Extracts: A Systematic Literature Review [PDF]

, 2023
Formulation of chewable tablets from extracts of natural ingredients requires special attention in designing preparations that maintain the quality and stability of the active ingredients.
Adam Permana, Adinda Khoirun Nissa, Adiva Nafila Zulfa, Nissa, Adinda Khoirun, Khoirul Haniatin, Nia Yuniarsih, Novita Andriyani   +6 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Development of Innovative Chewable Gel Tablets Containing Nutmeg Essential Oil Microcapsules and Their Physical Properties Evaluation

, 2021
Chewable gel tablets are a dosed pharmaceutical form, which can have an active substance, pharmacological effect, or value of nutrition. The texture of these tablets is soft, springy, flexible, and elastic—this is influenced by the chosen ingredients ...
Inga Matulyte, Mindaugas Marksa, Jurga Bernatoniene   +2 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Protocol for production of a chewable material for masticatory function tests (Optocal - Brazilian version)

Brazilian Oral Research, 2008
The present article aimed to present a standardized protocol for the production of a chewable test material that has been used in masticatory efficiency and performance studies.
Rafael de Liz Pocztaruk, Luis Carlos da Fontoura Frasca, Elken Gomes Rivaldo, Eduardo de Lima Fernandes, Maria Beatriz Duarte Gavião   +4 more
doaj   +1 more source

Acceptance of oclacitinib maleate (Apoquel®) chewable tablets in client-owned dogs with allergic and atopic dermatitis

BMC Veterinary Research, 2022
Background The oral acceptance of oclacitinib maleate (Apoquel®) chewable tablets administered twice daily for 7 days at the labeled dose range of 0.4–0.6 mg/kg was evaluated in 121 dogs treated at ten general practice veterinary clinics in the United ...
Marike Visser, Kelly Walsh, Vickie King, Gordon Sture, Laura Caneva   +4 more
doaj   +1 more source