Results 61 to 70 of about 3,636,957 (301)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Poverty Matters: It's Now 50/50, Chicago Region Poverty Growth is a Suburban Story [PDF]
, 2013 Nationwide, the number of people in poverty in the suburbs has now surpassed the number of people in poverty in central cities. Cities have long been thought to be home to the most and worst poverty. However, in the past several decades, the suburbs have
Amy Terpstra +2 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Artisan Culture and the Organization of Chicago\u27s German Workers in the Gilded Age, 1860 to 1890 [PDF]
, 1984 This essay evaluates the nature of German artisan culture in gilded-age Chicago and its role in the organization of modem working-class institutions. Three examples- the Workingmen\u27s Associations of Chicago\u27s German workers in the 1850s and 1860s ...
Jentz, John
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Les Cahiers ALHIM, 2003 This article focuses on second generation Latinos in the Chicago Metropolitan Area where the income gap between minority groups and Anglos is still growing. Several metropolitan Chicago Latino areas showed underemployment.
Laurence Gervais-Linon
doaj +1 more source
Creating Opportunity for Immigrant Women and Girls in the Chicago Region: Recommendations for the Chicago Foundation for Women's Civic Plan [PDF]
, 2015 Division sought to understand what economic, health, and violence-related issues are most pressing for immigrant women in the Chicago region, their families, and their communities.
Amy Rynell +6 more
core
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Psychotherapy and the Problems of Values [PDF]
, 1974 The author is an assistant professor in the Department of Psychiatry, School of Medicine, Case Western Reserve University, Cleveland and Director of Outpatient Psychiatry Day-Clinic, Cleveland Metropolitan General Hospital. Dr.
Dulin, John T.
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source