Results 111 to 120 of about 3,552 (200)

The gut microbiome and drug‐resistant epilepsy: Microbiome–antiseizure medication interactions and implications for pharmacoresistance

Epilepsia Open, EarlyView.
Abstract Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy and represents a major unmet clinical need. While traditional hypotheses of pharmacoresistance have focused on alterations in drug targets, efflux transporter overexpression, and intrinsic disease severity, the gut microbiome has recently emerged as a ...
Khaled Zammar, Majd A. AbuAlrob, Musab Ali, Simona Lattanzi, Boulenouar Mesraoua   +4 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of Enterococcus faecium DSM 33761, Pediococcus acidilactici DSM 33758, Bifidobacterium animalis DSM 16284, Limosilactobacillus reuteri DSM 33751 and Ligilactobacillus salivarius DSM 16351 (Biomin® C5) for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding and minor poultry species for fattening and reared for laying/breeding (Biomin GmbH). [PDF]

EFSA J, 2023
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Villa RE, Woutersen R, Ortuño Casanova J, Pettenati E.   +18 more
europepmc   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

Arterial Perivascular Space‐Mediated Solute Transport in the Mouse Brain

Exploration, EarlyView.
The mechanisms underlying solute clearance from the brain parenchyma remain debated, with competing hypotheses involving bulk cerebrospinal fluid flow versus perivascular transport. Using multimodal in vivo imaging and computational modeling in mice, this study demonstrates that arterial pulsation drives bidirectional solute movement within the ...
Shiyong Li, Ye Wang, Guangyu Jia, Yamei Yu, Zhe Zhang, Qi Wang, Kaelyn V. Becker, Jonathan W. Engle, Dawei Jiang, Weibo Cai   +9 more
wiley   +1 more source

Influence of Adhesive Type on Heat Induced Delamination in Tension Loaded Shear Lap Cross‐Laminated Timber Samples Exposed to Radiant Heat Flux

Fire and Materials, EarlyView.
ABSTRACT Heat induced delamination (HID) is a phenomenon in engineered wood products which may result in the detachment of the bonded timber lamellae before charring propagates to the bond line interphase. This study aims to correlate the thermal degradation of two 1‐c‐polyurethane adhesives at the microscale to the thermo‐hydro‐mechanical behaviour of
A. Čolić, F. Wiesner, M. Spearpoint, D. Hopkin, L. Bisby   +4 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of sodium ferrocyanide and potassium ferrocyanide for all animal species (Eusalt a.i.s.b.l.)

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of sodium ferrocyanide and potassium ferrocyanide as technological feed additives for all animal species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Jaume Galobart, Maria Vittoria Vettori, Elena Rovesti, Matteo Innocenti   +20 more
doaj   +1 more source

Offspring Global DNA Methylation is not Affected by Parental Developmental Stress Experience in a Passerine Species

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Rapid phenotypic change may be mediated by intergenerational transmission of early developmental experiences. In birds, exposure to glucocorticoids during early development can alter global DNA methylation and gene expression. However, DNA methylation is labile, and it is currently unclear whether the impacts of stress suffered during juvenile
Anna Miltiadous, Harrison J. F. Eyck, Ondi L. Crino, Lee A. Rollins, Damien Callahan, Katherine L. Buchanan   +5 more
wiley   +1 more source

Looking at Soil as It Is: Evolution of Microscopic Soil Characterization From Kubiëna to Artificial Intelligence

Journal of Plant Nutrition and Soil Science, EarlyView.
We provide a historic overview of microscopic soil structure characterization from its founding father, Walter Kubiëna, to several technical revolutions like automation, digitalization, and artificial intelligence. In addition to technical advancements, we explore how concepts and research questions have evolved in time.
Steffen Schlüter, Maik Geers‐Lucas, Peter Kühn, Hans‐Jörg Vogel   +3 more
wiley   +1 more source

Safety and efficacy of a feed additive consisting of xylanase (produced with Komagataella phaffii DSM 25376) and β‐glucanase (produced with Komagataella phaffii DSM 26469) (ENZY CARBOPLUS®) for all poultry (Kaesler Nutrition GmbH)

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of xylanase (produced with Komagataella phaffii DSM 25376) and β‐glucanase (produced with Komagataella phaffii DSM 26469) (ENZY ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Baltasar Mayo, Lieve Herman, Montserrat Anguita, Nicole Bozzi Cionci, Matteo L. Innocenti, Jordi Ortuño, Elisa Pettenati   +23 more
doaj   +1 more source

Safety and efficacy of a feed additive consisting of endo-1,4-β-xylanase produced by Komagataella phaffii DSM 33574 (Xylamax) for chickens and turkeys for fattening, chickens reared for laying/breeding, turkeys reared for breeding and minor poultry species for fattening or raised to the point of lay (BioResource international, Inc.). [PDF]

EFSA J, 2022
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Fašmon Durjava M, Kouba M, López-Alonso M, López Puente S, Marcon F, Mayo B, Pechová A, Petkova M, Ramos F, Ramos F, Sanz Y, Villa RE, Woutersen R, Glandorf B, Svensson K, Zeljezic D, Anguita M, Brozzi R, Galobart J, Ortuño J, Revez J, Tarrés-Call J, Pettenati E.   +28 more
europepmc   +1 more source