Results 51 to 60 of about 14,798 (236)

Treatment of Chikungunya Virus (CHIKV) Using Targeted Immunotherapy

, 2022
Chikungunya virus (CHIKV) is the most common mosquito-borne Alphavirus infecting humans worldwide. Up to date, there are no antiviral treatments or vaccines approved to treat or prevent CHIKV for which treatments remain symptomatic based on clinical manifestations.
Nsole, Biteghe, Fleury Augustin, Ekome, Toung, Chalomie Nyangone, Croix, Ndong, Jean De La, Neelakshi, Mungra,, B., Dar, Tahir, Kombe, , Arnaud John   +5 more
openaire   +3 more sources

A Case of Initially Undiagnosed Chikungunya Arthritis Developing into Chronic Phase in a Nonendemic Area

Case Reports in Medicine, 2017
This case report described a 40-year-old lady presented with fever, headache, arthralgia, myalgia, and impaired liver function after returning from the Philippines. Chikungunya virus (CHIKV) and dengue serology were negative.
Pui Shan Julia Chan, Moon Ho Leung
doaj   +1 more source

Evaluation of novobiocin and telmisartan for anti-CHIKV activity

Virology, 2020
Chikungunya has re-emerged as an epidemic with global distribution and high morbidity, necessitating the need for effective therapeutics. We utilized already approved drugs with a good safety profile used in other diseases for their new property of anti-chikungunya activity.
Praveen Kumar, Tripathi, Anjali, Soni, Shiv Pratap, Singh Yadav, Ankit, Kumar, Nitika, Gaurav, Siva, Raghavendhar, Pradeep, Sharma, Sujatha, Sunil, , Ashish, Bhyravabhotla, Jayaram, Ashok Kumar, Patel   +10 more
openaire   +2 more sources

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna, Liu, Jisheng, Smagghe, Guy, Swevers, Luc   +3 more
core   +1 more source

Characterizing Chikungunya: A Study of Clinical Symptoms, Laboratory Parameters, and Therapeutics

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Background: Chikungunya fever is a re-emerging viral infection of global importance, transmitted to humans by infected Aedes aegypti mosquitoes. The disease typically presents with fever, joint pain, and skin rashes, but recent outbreaks, particularly in
Rahil Arora, Santosh Kumar Singh, Rohit Vashisht, Ayon Gupta, Saurabh Bobdey, Robin Prasad, Mahesh Reddy, Manish Bhartiya, Anand Menon, Hari Prasad Sirigiri   +9 more
doaj   +1 more source

Knockdown of piRNA pathway proteins results in enhanced Semliki forest virus production in mosquito cells [PDF]

, 2013
The exogenous siRNA pathway is important in restricting arbovirus infection in mosquitoes. Less is known about the role of the PIWI-interacting RNA pathway, or piRNA pathway, in antiviral responses. Viral piRNA-like molecules have recently been described
Donald, Claire L., Fazakerley, John K., Fragkoudis, Rennos, Human, Stacey, Kohl, Alain, McFarlane, Melanie, Schnettler, Esther, Siu, Ricky W. C., Watson, Mick   +8 more
core   +3 more sources

Detection of Chikungunya virus (CHIKV) in urine of infected mice: a Potential Non-invasive Diagnostic Tool for CHIKV

Journal of Infectious Diseases & Therapy, 2015
Background: The reemergence of Chikungunya virus (CHIKV) infection and the spread of the virus throughout the world call for a fast, reliable, and improved laboratory diagnostic procedures. The aim of this study was to determine if CHIKV genome is present in other body fluids besides plasma as a tool for developing non-invasive diagnostic method ...
Jones PH, Okeoma CM
openaire   +1 more source

Evidence of Chikungunya virus seroprevalence in Myanmar among dengue-suspected patients and healthy volunteers in 2013, 2015, and 2018.

PLoS Neglected Tropical Diseases, 2021
IntroductionChikungunya virus (CHIKV) is a mosquito-borne virus known to cause acute febrile illness associated with debilitating polyarthritis. In 2019, several institutions in Myanmar reported a CHIKV outbreak.
Elizabeth Ajema Chebichi Luvai, Aung Kyaw Kyaw, Nundu Sabiti Sabin, Fuxun Yu, Saw Wut Hmone, Kyaw Zin Thant, Shingo Inoue, Kouichi Morita, Mya Myat Ngwe Tun   +8 more
doaj   +1 more source

Immune Response to Chikungunya Virus: Sex as a Biological Variable and Implications for Natural Delivery via the Mosquito

Viruses, 2023
Chikungunya virus (CHIKV) is a mosquito-borne virus with significant public health implications around the world. Climate change, as well as rapid urbanization, threatens to expand the population range of Aedes vector mosquitoes globally, increasing ...
Meagan Taylor, Jonathan O. Rayner
doaj   +1 more source

Evidence for endemic chikungunya virus infections in Bandung, Indonesia. [PDF]

PLoS Neglected Tropical Diseases, 2013
Chikungunya virus (CHIKV) is known to cause sporadic or explosive outbreaks. However, little is known about the endemic transmission of CHIKV. To ascertain the endemic occurrence of CHIKV transmission, we tested blood samples from patients with a non ...
Herman Kosasih, Quirijn de Mast, Susana Widjaja, Primal Sudjana, Ungke Antonjaya, Chairin Ma'roef, Silvita Fitri Riswari, Kevin R Porter, Timothy H Burgess, Bachti Alisjahbana, Andre van der Ven, Maya Williams   +11 more
doaj   +1 more source