Results 71 to 80 of about 15,961 (231)

Expression of truncated CHIKV nsP2.

, 2013
Schematic representation of CHIKV nsP2: N- terminal helicase domain (white) and C-terminal protease domain (gray) are indicated in the figure. The two proteins expressed were, CHIKV-Hel (166–441 a.a.) and CHIKV-nsP2T (166–630 a.a.).
Yogesh A. Karpe (348096), Pankaj P. Aher (348097), Kavita S. Lole (240553)   +2 more
core   +1 more source

Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidate

Scientific Reports, 2022
Chikungunya virus (CHIKV) is the causative agent of Chikungunya fever, an acute febrile and arthritogenic illness with no effective treatments available. The development of effective therapeutic strategies could be significantly accelerated with detailed
Marjorie C. L. C. Freire, Luis G. M. Basso, Luis F. S. Mendes, Nathalya C. M. R. Mesquita, Melina Mottin, Rafaela S. Fernandes, Lucca R. Policastro, Andre S. Godoy, Igor A. Santos, Uriel E. A. Ruiz, Icaro P. Caruso, Bruna K. P. Sousa, Ana C. G. Jardim, Fabio C. L. Almeida, Laura H. V. G. Gil, Carolina H. Andrade, Glaucius Oliva   +16 more
doaj   +1 more source

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão   +9 more
wiley   +1 more source

CHIKV E1-226V strains that were aligned to produce the CHIKV LS3 consensus sequence.

, 2013
CHIKV E1-226V strains that were aligned to produce the CHIKV LS3 consensus sequence.
Eric J. Snijder (45119), Krishna Narayanan (193201), Paolo Cordioli (235218), Shinji Makino (19911), Florine E. M. Scholte (440416), Byron E. E. Martina (162110), Martijn J. van Hemert (45114), Ali Tas (440417)   +7 more
core   +1 more source

γδ T Cells Mediate Protective Immunity Following Vaccination with an Insect-Based Chikungunya Fever Vaccine in Mice

Pathogens
Eilat (EILV)/chikungunya virus (CHIKV) is a chimeric virus that contains the nonstructural proteins and cis-acting sequences of EILV and the structural proteins of CHIKV. EILV/CHIKV vaccination is known to protect with a single dose against wild-type (WT)
Leslie Rodriguez, Awadalkareem Adam, Huanle Luo, Samantha R. Osman, Kenneth Plante, Shannan L. Rossi, Scott C. Weaver, Tian Wang   +7 more
doaj   +1 more source

Molecular and Serological Screening of West Nile and Usutu Virus in Birds and Humans: A Sentinel Study in Finland

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
We developed sensitive real‐time PCR assays for West Nile virus and Usutu virus to screen bird and human samples in Finland. Although no positive samples were detected, active migratory flyways and recent cases in neighbouring countries highlight the risk of future introduction and the need for continued surveillance.
Ruut Joensuu, Maija T. Suvanto, Sanna Sainmaa, Viktor Olander, Roope Nykänen, Essi M. Korhonen, Anne J. Jääskeläinen   +6 more
wiley   +1 more source

Cell Tropism of CHIKV

, 2013
(A–C) The indicated human cell lines or primary cells were exposed to CHIKV at an moi of 10. At 24 h pi, cells were fixed, stained with anti-CHIKV antibodies, and analyzed by flow cytometry. The percentage of CHIKV-infected cells is indicated.
Céline Trouillet (31905), Karin Le Roux (31909), Alain Michault (31924), Marie-Pascale Frenkiel (31912), Philippe V Afonso (31914), Hafida Fsihi (31911), Ali Saïb (31921), Nicoletta Casartelli (31904), Simona Ozden (31916), Nathalie Sol-Foulon (31908), Matthew L Albert (31925), Florence Guivel-Benhassine (31906), Marion Sourisseau (31902), Clémentine Schilte (31903), Alessia Zamborlini (31920), Isabelle Schuffenecker (31918), Dominika Rudnicka (31907), Marie-Christine Prevost (31910), Felix A Rey (31922), Fabien Blanchet (31913), Olivier Schwartz (15284), Bruno Verhasselt (31919), Antoine Gessain (31917), Fernando Arenzana-Seisdedos (18907), Pierre-Emmanuel Ceccaldi (31915), Philippe Desprès (31923)   +25 more
core   +1 more source

Miltefosine inhibits Chikungunya virus replication in human primary dermal fibroblasts [version 1; referees: 2 approved, 1 approved with reservations]

F1000Research, 2018
Background: Chikungunya virus (CHIKV) is a re-emerging pathogen that has caused widespread outbreaks affecting millions of people around the globe. Currently, there is no specific therapeutic drug against CHIKV, with symptomatic treatment only to manage ...
Anuj Sharma, Manish Bhomia, Tze-Jou Yeh, Jay Singh, Radha K. Maheshwari   +4 more
doaj   +1 more source

Analyzing Upper Extremity Disability From Health‐Related Quality of Life in Chronic Chikungunya: A Biopsychosocial Approach

Journal of Evaluation in Clinical Practice, Volume 32, Issue 6, September 2026.
ABSTRACT Relevance to the Journal Responding to the Journal of Evaluation in Clinical Practice's emphasis on person‐centered care, this study examines how pain, functional capacity and vitality influence lived disability and rehabilitation needs in individuals with chronic chikungunya.
Raildo Oliveira da Silva Filho, Marynara Fabíola Silva Araújo, Andreia Ravinia do Nascimento Oliveira, Maria Eduarda Medeiros da Costa Figueiredo, Dimitri Taurino Guedes, Renata Newman Leite dos Santos Lucena, Leonildo Santos do Nascimento Junior, Thais Marques Lima, Eleazar Marinho de Freitas Lucena   +8 more
wiley   +1 more source

Pre-infection treatment assays of SJCRH30 against CHIKV-6708 and CHIKV-122508 with EIPA.

, 2019
SJCRH30 were pre-treated with EIPA for 3 hours before infection with CHIKV-122508 and CHIKV-6708. Supernatants were harvested at 24 h.p.i for viral plaque assays. The virus titre expressed as log10 PFU/mLis plotted against the concentrations of drug used.
Khairunnisa Mohamed Hussain (7310264), Justin Jang Hann Chu (7310267), Ching Hua, Regina Lee (7310261)   +2 more
core   +1 more source