Results 81 to 90 of about 7,593,002 (356)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

GPs’ strategies in exploring the preschool child’s wellbeing in the paediatric consultation [PDF]

, 2013
Background: Although General Practitioners (GPs) are uniquely placed to identify children with emotional, social, and behavioural problems, they succeed in identifying only a small number of them.
A Heikkinen, A Poulsen, AM Skovgaard, AR Miller, BF Crabtree, C Nova, D Cawthorpe, D Hall, DA Schön, DA Schön, E Christensen, J Gabe, K Lykke, K Lykke, K Lykke, K Sayal, K Tates, Kirsten Lykke, L Flachs, LA King, LS Wissow, M Zwaanswijk, MH Theunissen, O Walker, P Cahill, P Cahill, P Christensen, Pia Christensen, PS Byrne, S Michelsen, Susanne Reventlow, VM Klein, YH Carter   +32 more
core   +3 more sources

Digital games and virtual reality applications in child abuse: A scoping review and conceptual framework

, 2022
Afsoon Asadzadeh, Hassan Shahrokhi, Behzad Shalchi, Zhila Khamnian, Peyman Rezaei‐Hachesu   +4 more
openalex   +2 more sources

Pedatric Nutrition: Feed Your Child Discerning [PDF]

, 2021
Ihab A. Naser
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Early years care and education [PDF]

Children learn and develop through a combination of experiences, within and outside the family home. This Policy Brief explores the distinction that is often made about the role of care and education in children’s services and highlights the importance ...
Centre for Community Child Health
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Has incentive payment improved venous thrombo-embolism risk assessment and treatment of hospital in-patients? [v1; ref status: indexed, http://f1000r.es/8k]

F1000Research, 2013
This paper focuses on financial incentives rewarding successful implementation of guidelines in the UK National Health Service (NHS). In particular, it assesses the implementation of National Institute for Health and Clinical Excellence (NICE) venous ...
Sue Child, Rod Sheaff, Olga Boiko, Alice Bateman, Christian A Gericke   +4 more
doaj   +1 more source

Caring for young children: what children need [PDF]

Caring for young children, and getting the caring right, is becoming recognised as one of the most significant challenges facing parents, communities and societies. Young children who develop secure attachments through positive caregiving are more likely
Centre for Community Child Health
core